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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx3
T-box 3
MGI:98495
82 phenotypes from 9 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Tbx3em1(IMPC)Mbp/\Tbx3+
C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal lymph node morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
decreased locomotor activity J:211773
eye hemorrhage J:211773
increased circulating alkaline phosphatase level J:211773
microphthalmia J:211773
\Tbx3em1(IMPC)Mbp/\Tbx3em1(IMPC)Mbp
C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
\Tbx3tm1.1(cre)Vmc/\Tbx3+
involves: 129P2/OlaHsd * FVB/N * NMRI 		no abnormal phenotype detected J:154920
\Tbx3tm1.1(cre)Vmc/\Tbx3tm1.1(cre)Vmc
involves: 129P2/OlaHsd * FVB 		abnormal limb morphology J:121230
abnormal mammary gland development J:121230
abnormal sinoatrial node morphology J:121230
decreased sinoatrial node size J:121230
embryonic lethality during organogenesis, complete penetrance J:121230
\Tbx3tm1.1(cre)Vmc/\Tbx3tm1.1(cre)Vmc
involves: 129P2/OlaHsd * FVB/N * NMRI 		abnormal palatal shelf fusion at midline J:154920
cleft secondary palate J:154920
lethality throughout fetal growth and development, complete penetrance J:154920
\Tbx3tm1.1Moon/\Tbx3+
involves: 129 * C57BL/6 * SJL 		irregular heartbeat J:179977
reduced female fertility J:179977
reduced male fertility J:179977
\Tbx3tm1.1Moon/\Tbx3tm1.1Moon
involves: 129 * C57BL/6 * SJL 		abnormal heart development J:179977
embryonic lethality, incomplete penetrance J:179977
\Tbx3tm1.1Moon/\Tbx3tm2Moon
involves: 129 * C57BL/6 * SJL 		abnormal cardiovascular development J:179977
abnormal limb morphology J:179977
atrioventricular block J:179977
decreased heart rate J:179977
normal embryo phenotype J:179977
embryonic lethality during organogenesis, incomplete penetrance J:179977
irregular heartbeat J:179977
lethality throughout fetal growth and development, complete penetrance J:179977
sinoatrial node hypoplasia J:179977
ventricular septal defect J:179977
\Tbx3tm1Jcib/\Tbx3tm1Jcib
involves: 129S4/SvJae * C57BL/6 		abnormal fetal atrioventricular canal morphology J:129349
abnormal heart looping J:129349
abnormal vitelline vasculature morphology J:129349
decreased body size J:129349
delayed heart looping J:129349
failure of heart looping J:129349
pericardial edema J:129349
short hindlimb J:129349
\Tbx3tm1Pa/\Tbx3+
either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac) 		abnormal clitoris morphology J:82458
abnormal female reproductive system morphology J:82458
abnormal vagina orifice morphology J:82458
\Tbx3tm1Pa/\Tbx3tm1Pa
either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac) 		abnormal digit morphology J:82458
abnormal embryonic autopod plate morphology J:82458
abnormal forelimb morphology J:82458
abnormal hindlimb morphology J:82458
abnormal hindlimb zeugopod morphology J:82458
abnormal limb development J:82458
abnormal limb morphology J:82458
abnormal mammary gland bud morphology J:82458
abnormal mammary gland embryonic development J:82458
abnormal pelvic girdle bone morphology J:82458
abnormal ulna morphology J:82458
abnormal visceral yolk sac endoderm morphology J:82458
abnormal vitelline vasculature morphology J:82458
absent carpal bone J:82458
absent mammary gland J:82458
absent metacarpal bones J:82458
absent vitelline blood vessels J:82458
embryonic lethality during organogenesis, incomplete penetrance J:82458
pale yolk sac J:82458
small hindlimb buds J:82458
small liver J:82458
thin apical ectodermal ridge J:82458
\Tbx3tm2.1Moon/\Tbx3tm2.1Moon
involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL 		abnormal impulse conducting system conduction J:179977
abnormal P wave J:179977
abnormal QRS complex J:179977
abnormal sinus arrhythmia J:179977
absent P wave J:179977
absent PR interval J:179977
atrioventricular block J:179977
decreased heart rate J:179977
increased heart rate variability J:179977
irregular heartbeat J:179977
premature death J:179977
preweaning lethality, incomplete penetrance J:179977
prolonged QRS complex duration J:179977
shortened PR interval J:179977
sinus bradycardia J:179977
\Tbx3tm2.1Moon/\Tbx3tm2.1Moon
involves: 129 * BALB/cJ * C57BL/6 * SJL 		abnormal cardiovascular development J:179977
abnormal digit morphology J:179977
abnormal inferior vena cava morphology J:179977
absent carpal bone J:179977
absent fibula J:179977
absent tarsus bones J:179977
absent ulna J:179977
atrioventricular block J:179977
decreased heart rate J:179977
edema J:179977
normal embryo phenotype J:179977
increased cardiac muscle contractility J:179977
irregular heartbeat J:179977
oligodactyly J:179977
postnatal lethality, incomplete penetrance J:179977
prenatal lethality, incomplete penetrance J:179977
prolonged QRS complex duration J:179977
sinoatrial node hypoplasia J:179977
ventricular septal defect J:179977
\Tbx3tm2Moon/\Tbx3+
involves: 129 * C57BL/6 		irregular heartbeat J:179977
\Tbx3tm3.1Moon/\Tbx3tm3.1Moon
\Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 		abnormal sinus arrhythmia J:179977
atrioventricular block J:179977
\Tbx3tm3.1Moon/\Tbx3tm3.1Moon
\Tg(GATA6-cre)#Jbeb/0
involves: 129 * C57BL/6 		atrioventricular block J:179977
\Tbx3tm3.1Moon/\Tbx3tm3.1Moon
\Tg(Mef2c-cre)2Blk/0
involves: 129 * C57BL/6 		atrioventricular block J:179977
embryonic lethality during organogenesis, incomplete penetrance J:179977
irregular heartbeat J:179977
\Tbx3tm3.2Moon/\Tbx3tm3.2Moon
involves: 129 * BALB/cJ * C57BL/6 * SJL 		atrioventricular block J:179977
decreased heart rate J:179977
embryonic lethality, complete penetrance J:179977
irregular heartbeat J:179977
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory