Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including atrioventricular canal morphogenesis; embryonic morphogenesis; and regulation of protein complex stability. Acts upstream of or within several processes, including circulatory system development; mammary gland morphogenesis; and regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is active in cilium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study ulnar-mammary syndrome. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3).