Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STC2
  • Mouse genes Stc2
  • Rat genes Stc2
  • Zfish genes stc2a,stc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	STC2	IDA		Human	PMID:22503972
Molecular Function	GO:0020037	heme binding	STC2	IDA		Human	PMID:22503972
Molecular Function	GO:0005515	protein binding	Stc2	IPI	PR:P70302	Mouse	PMID:21746875
Molecular Function	GO:0042803	protein homodimerization activity	STC2	IDA		Human	PMID:15486227
Cellular Component	GO:0005783	endoplasmic reticulum	STC2	IDA		Human	PMID:22503972
Cellular Component	GO:0005783	endoplasmic reticulum	Stc2	IDA		Mouse	PMID:15485913
Cellular Component	GO:0005615	extracellular space	STC2	HDA		Human	PMID:16502470
Cellular Component	GO:0005794	Golgi apparatus	Stc2	IDA		Mouse	PMID:15485913
Cellular Component	GO:0048471	perinuclear region of cytoplasm	STC2	IDA		Human	PMID:22503972
Biological Process	GO:0055074	calcium ion homeostasis	Stc2	IGI	MGI:MGI:1101771	Mouse	PMID:22285620
Biological Process	GO:0071456	cellular response to hypoxia	Stc2	IEP		Rat	PMID:15485913|RGD:2324700
Biological Process	GO:0046697	decidualization	Stc2	IEP		Rat	PMID:16735553|RGD:2324698
Biological Process	GO:0007566	embryo implantation	Stc2	IEP		Rat	PMID:16735553|RGD:2324698
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Stc2	IMP		Mouse	PMID:15485913
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Stc2	IMP	MGI:MGI:5285561	Mouse	PMID:21746875
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Stc2	IMP		Rat	PMID:21746875|RGD:8553795
Biological Process	GO:0010629	negative regulation of gene expression	STC2	IDA		Human	PMID:9753616
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Stc2	IMP	MGI:MGI:3799310	Mouse	PMID:18258678
Biological Process	GO:0046885	regulation of hormone biosynthetic process	STC2	IDA		Human	PMID:9753616
Biological Process	GO:2001256	regulation of store-operated calcium entry	Stc2	IMP	MGI:MGI:5285561	Mouse	PMID:21746875
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Stc2	IMP	MGI:MGI:5285561	Mouse	PMID:21746875
Biological Process	GO:0006979	response to oxidative stress	Stc2	IMP	MGI:MGI:5285561	Mouse	PMID:21746875
Biological Process	GO:0043434	response to peptide hormone	Stc2	IEP		Rat	PMID:15486227|RGD:2324699
Biological Process	GO:0033280	response to vitamin D	Stc2	IEP		Rat	PMID:10508929|RGD:634221

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern