About   Help   FAQ
Stc2 Gene Detail
Summary
  • Symbol
    Stc2
  • Name
    stanniocalcin 2
  • Synonyms
    mustc2, Stc2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316731
    NCBI Gene: 20856
  • Gene Overview
    MyGene.info: STC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:31359441-31370061 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 18.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316731
protein coding gene Chr11:31357307-31370074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018121
protein coding gene Chr11:29490725-29503496 (-)
A/J MGP_AJ_G0018094
protein coding gene Chr11:28406445-28419239 (-)
AKR/J MGP_AKRJ_G0018058
protein coding gene Chr11:29295004-29307785 (-)
BALB/cJ MGP_BALBcJ_G0018063
protein coding gene Chr11:28589300-28602093 (-)
C3H/HeJ MGP_C3HHeJ_G0017876
protein coding gene Chr11:29252783-29265542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018515
protein coding gene Chr11:30482286-30495053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016170
protein coding gene Chr11:26898872-26911567 (-)
CAST/EiJ MGP_CASTEiJ_G0017438
protein coding gene Chr11:29262104-29290482 (-)
CBA/J MGP_CBAJ_G0017849
protein coding gene Chr11:31892541-31905331 (-)
DBA/2J MGP_DBA2J_G0017959
protein coding gene Chr11:28201141-28213933 (-)
FVB/NJ MGP_FVBNJ_G0017953
protein coding gene Chr11:28009929-28022714 (-)
LP/J MGP_LPJ_G0018031
protein coding gene Chr11:29747803-29760847 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017977
protein coding gene Chr11:32986128-32998897 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018556
protein coding gene Chr11:29404146-29416916 (-)
PWK/PhJ MGP_PWKPhJ_G0017220
protein coding gene Chr11:28319944-28350366 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017014
protein coding gene Chr11:29121945-29134736 (-)
WSB/EiJ MGP_WSBEiJ_G0017490
protein coding gene Chr11:29072259-29085028 (-)



Homology
more
  • Human Ortholog
    STC2, stanniocalcin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STC2, stanniocalcin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    STC-2, STCRP
  • Links
    NCBI Gene ID: 8614
    neXtProt AC: NX_O76061
    UniProt: O76061

  • Chr Location
    5q35.2; chr5:173314723-173329503 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2753
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are 10-15% larger and grow at a faster rate than wild-type controls from 4 weeks onward. The increased body weight results from an increase in the weight of most major organs, with the exception of testis. Mean alkaline phosphatase levels are 144% of wild-type levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20856 NCBI Gene Model | MGI Sequence Detail 10621 C57BL/6J ±  kb
    transcript NM_011491 RefSeq | MGI Sequence Detail 1793 Not Specified  
    polypeptide O88452 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1316647, MGI:2144507
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:219345 Jepsen MR, et al., Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem. 2015 Feb 6;290(6):3430-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory