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Stc2
Gene Detail
 Symbol
Name
ID
Stc2
stanniocalcin 2
MGI:1316731
Synonyms mustc2, Stc2l
Feature Type protein coding gene
Genetic Map
Chromosome 11
18.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:31357307-31370074 bp, - strand
From VEGA annotation of GRCm38

  12768 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Stc2

Human
homologs
Human Homolog STC2, stanniocalcin 2
NCBI Gene ID 8614
neXtProt AC  NX_O76061
Human Synonyms  STC-2, STCRP
Human Chr (Location)  5q35.1; chr5:173314723-173329503 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Homozygous null mice are 10-15% larger and grow at a faster rate than wild-type controls from 4 weeks onward. The increased body weight results from an increase in the weight of most major organs, with the exception of testis. Mean alkaline phosphatase levels are 144% of wild-type levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process calcium ion homeostasis, cellular calcium ion homeostasis, ...
Component endoplasmic reticulum, extracellular region, ...
Function hormone activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (133)    Tissues (63)    Images (26)
Theiler Stages: 23, 26
Assay TypeResults
RNA in situ 129
Western blot 4
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005360 (Evidence)
Ensembl Gene ModelENSMUSG00000020303 (Evidence)
Entrez Gene20856 (Evidence)
DFCITC1584186, TC1605149, TC1677033
DoTSDT.55201408, DT.60104980, DT.94135828
NIA Mouse Gene IndexU032623, U311211
Consensus CDS ProjectCCDS24512.1
International Mouse Knockout Project StatusStc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005360 VEGA Gene Model | MGI Sequence Detail 12768 C57BL/6J ±  kb
transcript OTTMUST00000011957 VEGA | MGI Sequence Detail 3940 Not Applicable 
polypeptide OTTMUSP00000005531 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004978 Stanniocalcin
Protein Ontology PR:000015729 stanniocalcin-2
References (Earliest) J:49098 Chang AC, et al., Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Mol Cell Endocrinol. 1998 Jun 25;141(1-2):95-9
(Latest) J:183281 Takei Y, et al., Stanniocalcin 2 is associated with ectopic calcification in alpha-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012 Apr;50(4):998-1005
All references(37)
Other
accession IDs
MGI:1316647, MGI:2144507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory