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Stc2
Gene Detail
Symbol

Name
ID
Stc2
stanniocalcin 2
MGI:1316731
Synonyms
mustc2, Stc2l
Feature Type
protein coding gene
Genetic Map
Chromosome 11
18.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:31357307-31370074 bp, - strand
From VEGA annotation of GRCm38

  12768 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2753  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STC2
Gene Tree: Stc2

Human
homologs
STC2, stanniocalcin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8614
neXtProt AC: NX_O76061

Human Synonyms: STC-2, STCRP

Human Chr (Location): 5q35.1; chr5:173314723-173329503 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are 10-15% larger and grow at a faster rate than wild-type controls from 4 weeks onward. The increased body weight results from an increase in the weight of most major organs, with the exception of testis. Mean alkaline phosphatase levels are 144% of wild-type levels.
 
Interactions
Stc2 interacts with 297 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process calcium ion homeostasis, cellular calcium ion homeostasis, ...
Component cell, endoplasmic reticulum, ...
Function enzyme binding, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (133)    Tissues (63)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 129
Western blot 4
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stc2 ; ZFIN stc2a    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005360 (Evidence)
Ensembl Gene Model ENSMUSG00000020303 (Evidence)
Entrez Gene 20856 (Evidence)
DFCI TC1584186, TC1605149, TC1677033
DoTS DT.55201408, DT.60104980, DT.94135828
NIA Mouse Gene Index U032623, U311211
Consensus CDS Project CCDS24512.1
International Mouse Phenotyping Consortium Status Stc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005360 VEGA Gene Model | MGI Sequence Detail 12768 C57BL/6J ±  kb
transcript OTTMUST00000011957 VEGA | MGI Sequence Detail 3940 Not Applicable 
polypeptide OTTMUSP00000005531 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004978 Stanniocalcin
Protein Ontology PR:000015729 stanniocalcin-2
References
(Earliest) J:49098 Chang AC, et al., Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Mol Cell Endocrinol. 1998 Jun 25;141(1-2):95-9
(Latest) J:219345 Jepsen MR, et al., Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem. 2015 Feb 6;290(6):3430-9
All references(38)
Other
accession IDs
MGI:1316647, MGI:2144507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory