Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Smad5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SMAD5
- Mouse genes Smad5
- Rat genes Smad5
- Zfish genes smad5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smad5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	SMAD5	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Smad5	IDA		Mouse	MGI:MGI:5506700\|PMID:22964636
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q9Y2U8	Human	PMID:15647271
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q9NRR4	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q86VV4	Human	PMID:25755279
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q969T9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMAD5	IPI	UniProtKB:Q99732	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Smad5	IPI	UniProtKB:Q62424	Mouse	MGI:MGI:3589511\|PMID:16087734
Molecular Function	GO:0005515	protein binding	Smad5	IPI	PR:Q8CHP0	Mouse	PMID:16115198
Molecular Function	GO:0005515	protein binding	Smad5	IPI	PR:Q8R138	Mouse	PMID:21239498
Molecular Function	GO:0005515	protein binding	Smad5	IPI	PR:O88559	Mouse	PMID:15150273
Molecular Function	GO:0005515	protein binding	Smad5	IPI	UniProtKB:Q52KP6	Mouse	PMID:12370310
Molecular Function	GO:0005515	protein binding	smad5	IPI	ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24488494
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SMAD5	IDA		Human	PMID:28369590
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Smad5	IDA		Mouse	PMID:18692037
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Smad5	IDA		Mouse	MGI:MGI:5905276\|PMID:11729207
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SMAD5	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	smad5	IDA		Zfish	PMID:24488494
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SMAD5	IPI	UniProtKB:Q9HCE7	Human	PMID:11278251
Cellular Component	GO:0005737	cytoplasm	Smad5	IDA		Mouse	MGI:MGI:4352622\|PMID:19252488
Cellular Component	GO:0005737	cytoplasm	Smad5	IDA		Mouse	PMID:19103752
Cellular Component	GO:0005829	cytosol	SMAD5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SMAD5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Smad5	IDA		Mouse	MGI:MGI:4352622\|PMID:19252488
Cellular Component	GO:0005634	nucleus	Smad5	IDA		Mouse	MGI:MGI:3693397\|PMID:12151307
Cellular Component	GO:0005634	nucleus	Smad5	IDA		Mouse	PMID:19793887
Cellular Component	GO:0005634	nucleus	Smad5	IDA		Mouse	PMID:19103752
Cellular Component	GO:0032991	protein-containing complex	SMAD5	IDA		Human	PMID:23610558
Biological Process	GO:0048514	blood vessel morphogenesis	smad5	IGI	ZFIN:ZDB-MRPHLNO-041217-8,ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4	Zfish	PMID:16556914
Biological Process	GO:0030509	BMP signaling pathway	Smad5	IGI	UniProtKB:P70340	Mouse	MGI:MGI:5487530\|PMID:20843790
Biological Process	GO:0030509	BMP signaling pathway	Smad5	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622\|PMID:19252488
Biological Process	GO:0030509	BMP signaling pathway	Smad5	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0030509	BMP signaling pathway	Smad5	IGI	MGI:MGI:109452	Mouse	PMID:19224984
Biological Process	GO:0030509	BMP signaling pathway	Smad5	IDA		Mouse	PMID:18590716
Biological Process	GO:0030509	BMP signaling pathway	smad5	IGI	ZFIN:ZDB-GENE-980526-474	Zfish	PMID:10207140\|ZFIN:ZDB-PUB-990507-8
Biological Process	GO:0030509	BMP signaling pathway	smad5	IMP		Zfish	PMID:10207140\|ZFIN:ZDB-PUB-990507-8
Biological Process	GO:0030509	BMP signaling pathway	smad5	IMP	ZFIN:ZDB-GENO-181113-11	Zfish	PMID:28599080
Biological Process	GO:0030509	BMP signaling pathway	smad5	IMP		Zfish	PMID:9676195
Biological Process	GO:0060348	bone development	Smad5	IGI	MGI:MGI:109452	Mouse	PMID:19224984
Biological Process	GO:0060348	bone development	Smad5	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0060048	cardiac muscle contraction	Smad5	IMP	MGI:MGI:2679443	Mouse	PMID:17456754
Biological Process	GO:0051216	cartilage development	Smad5	IGI	MGI:MGI:109452	Mouse	PMID:19224984
Biological Process	GO:0051216	cartilage development	Smad5	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0071773	cellular response to BMP stimulus	Smad5	IGI	UniProtKB:P70340	Mouse	MGI:MGI:5487530\|PMID:20843790
Biological Process	GO:0071407	cellular response to organic cyclic compound	Smad5	IDA		Mouse	PMID:19103752
Biological Process	GO:0048262	determination of dorsal/ventral asymmetry	smad5	IGI		Zfish	PMID:10207140
Biological Process	GO:0007368	determination of left/right symmetry	smad5	IMP		Zfish	PMID:9334285
Biological Process	GO:0048264	determination of ventral identity	smad5	IMP		Zfish	PMID:12376102
Biological Process	GO:0048264	determination of ventral identity	smad5	IMP	ZFIN:ZDB-GENO-980202-523	Zfish	PMID:12601179
Biological Process	GO:0048264	determination of ventral identity	smad5	IGI	ZFIN:ZDB-GENE-020812-3	Zfish	PMID:15525664
Biological Process	GO:0048264	determination of ventral identity	smad5	IMP		Zfish	PMID:9007231
Biological Process	GO:0048264	determination of ventral identity	smad5	IDA		Zfish	PMID:11222140
Biological Process	GO:0060030	dorsal convergence	smad5	IMP	ZFIN:ZDB-MRPHLNO-041217-8	Zfish	PMID:17331724
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IGI	ZFIN:ZDB-MRPHLNO-041217-8,ZFIN:ZDB-MRPHLNO-140620-6	Zfish	PMID:24488494
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IMP		Zfish	PMID:9676195
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IGI	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222140
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IMP	ZFIN:ZDB-MRPHLNO-041217-8	Zfish	PMID:24488494
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IMP	ZFIN:ZDB-MRPHLNO-100415-5,ZFIN:ZDB-MRPHLNO-100415-6	Zfish	PMID:19855136
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad5	IGI	ZFIN:ZDB-MRPHLNO-041217-8,ZFIN:ZDB-MRPHLNO-140620-7	Zfish	PMID:24488494
Biological Process	GO:0003143	embryonic heart tube morphogenesis	smad5	IMP		Zfish	PMID:9334285
Biological Process	GO:0009880	embryonic pattern specification	smad5	IMP		Zfish	PMID:10207140\|ZFIN:ZDB-PUB-990507-8
Biological Process	GO:0009880	embryonic pattern specification	smad5	IMP		Zfish	PMID:10590480\|ZFIN:ZDB-PUB-991115-2
Biological Process	GO:0009880	embryonic pattern specification	smad5	IMP	ZFIN:ZDB-MRPHLNO-080610-1	Zfish	PMID:20809932
Biological Process	GO:0030218	erythrocyte differentiation	Smad5	IMP		Mouse	PMID:15591122
Biological Process	GO:0007281	germ cell development	Smad5	IMP		Mouse	PMID:11404080
Biological Process	GO:0001947	heart looping	smad5	IMP		Zfish	PMID:9334285
Biological Process	GO:0001945	lymph vessel development	smad5	IMP	ZFIN:ZDB-MRPHLNO-140714-2	Zfish	PMID:24608800
Biological Process	GO:0001880	Mullerian duct regression	Smad5	IMP		Rat	PMID:16687449\|RGD:2303145
Biological Process	GO:0043066	negative regulation of apoptotic process	SMAD5	IMP		Human	PMID:26400397
Biological Process	GO:1902045	negative regulation of Fas signaling pathway	SMAD5	IMP		Human	PMID:26400397
Biological Process	GO:0010629	negative regulation of gene expression	SMAD5	IMP		Human	PMID:26400397
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Smad5	IDA		Mouse	MGI:MGI:5506700\|PMID:22964636
Biological Process	GO:0001503	ossification	Smad5	IEP		Rat	PMID:11920662\|RGD:724455
Biological Process	GO:0002051	osteoblast fate commitment	Smad5	IGI	MGI:MGI:1316736	Mouse	PMID:15150273
Biological Process	GO:0043049	otic placode formation	smad5	IEP		Zfish	PMID:9676195
Biological Process	GO:0060037	pharyngeal system development	smad5	IMP	ZFIN:ZDB-GENO-140905-2	Zfish	PMID:24514435
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	smad5	IDA		Zfish	PMID:24488494
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Smad5	IGI	MGI:MGI:1316736	Mouse	PMID:15150273
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad5	IDA		Mouse	PMID:15557274
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	Smad5	IGI	UniProtKB:P70340	Mouse	MGI:MGI:5487530\|PMID:20843790
Biological Process	GO:0036342	post-anal tail morphogenesis	smad5	IMP	ZFIN:ZDB-GENO-080610-1	Zfish	PMID:21610036
Biological Process	GO:0048922	posterior lateral line neuromast deposition	smad5	IMP	ZFIN:ZDB-MRPHLNO-041217-8	Zfish	PMID:25603803
Biological Process	GO:0048919	posterior lateral line neuromast development	smad5	IMP	ZFIN:ZDB-MRPHLNO-041217-8	Zfish	PMID:25603803
Biological Process	GO:0006468	protein phosphorylation	Smad5	IDA		Mouse	PMID:18776146
Biological Process	GO:0031099	regeneration	smad5	IMP	ZFIN:ZDB-GENO-181113-11	Zfish	PMID:28599080
Biological Process	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	smad5	IMP		Zfish	PMID:9334285
Biological Process	GO:0060021	roof of mouth development	smad5	IMP	ZFIN:ZDB-GENO-111206-1	Zfish	PMID:22016187
Biological Process	GO:0060395	SMAD protein signal transduction	Smad5	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622\|PMID:19252488
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad5	IDA		Mouse	PMID:11376112
Biological Process	GO:0001657	ureteric bud development	Smad5	IEP		Mouse	MGI:MGI:3525982\|PMID:14656760

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.