About   Help   FAQ
Smad5
Gene Detail
Symbol

Name
ID
Smad5
SMAD family member 5
MGI:1328787
Synonyms
Madh5, MusMLP, Smad 5
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr13:56703010-56742377 bp, + strand
From VEGA annotation of GRCm38

  39368 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4313  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Smad protein
Gene Tree: Smad5

Human
homologs
Human Homolog SMAD5, SMAD family member 5
NCBI Gene ID 4090
neXtProt AC  NX_Q99717
Human Synonyms  DWFC, JV5-1, MADH5
Human Chr (Location)  5q31; chr5:136132847-136182734 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit vascular, craniofacial, and neural tube defects, improper turning, edema, and a deficiency of primordial germ cells. Mutants die between embryonic days 10.5 and 11.5.
 
Human Diseases Modeled Using Mouse Smad5 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Smad5 interacts with 414 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process angiogenesis, BMP signaling pathway, ...
Component cytoplasm, intracellular, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (252 records)
Data Summary: Results (514)    Tissues (206)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 46
RNA in situ 328
Northern blot 12
Western blot 59
RT-PCR 69
cDNA source data(190)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) cDNA(191) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020956 (Evidence)
Ensembl Gene ModelENSMUSG00000021540 (Evidence)
Entrez Gene17129 (Evidence)
UniGene272920
DFCITC1575792, TC1579338, TC1597463, TC1675838
DoTSDT.101284508, DT.101382028, DT.101382029, DT.101382030, DT.491643, DT.55215179, DT.91403180, DT.94219199
NIA Mouse Gene IndexU043341
Consensus CDS ProjectCCDS26565.1
International Mouse Knockout Project StatusSmad5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020956 VEGA Gene Model | MGI Sequence Detail 39368 C57BL/6J ±  kb
transcript OTTMUST00000049540 VEGA | MGI Sequence Detail 6584 Not Applicable 
polypeptide OTTMUSP00000022970 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013790 Dwarfin
InterPro IPR003619 MAD homology 1, Dwarfin-type
InterPro IPR013019 MAD homology, MH1
InterPro IPR001132 SMAD domain, Dwarfin-type
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000000372 smad5
References
(Earliest) J:51722 Yingling JM, et al., Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8940-4
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(336)
Other
accession IDs
MGI:1923577, MGI:2145246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory