Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc6a4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC6A4
- Mouse genes Slc6a4
- Rat genes Slc6a4
- Zfish genes slc6a4a,slc6a4b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Slc6a4	IDA		Rat	PMID:15627510\|RGD:8553308
Molecular Function	GO:0019811	cocaine binding	Slc6a4	IMP		Rat	PMID:15994310\|RGD:1580635
Molecular Function	GO:0042802	identical protein binding	Slc6a4	IPI	UniProtKB:P31652	Rat	PMID:10716733\|RGD:8554226
Molecular Function	GO:0042802	identical protein binding	Slc6a4	IMP		Rat	PMID:12944413\|RGD:1580638
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC6A4	IDA		Human	PMID:16024787
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc6a4	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc6a4	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Molecular Function	GO:0050998	nitric-oxide synthase binding	Slc6a4	IPI	UniProtKB:Q9Z0J4	Mouse	MGI:MGI:3710710\|PMID:17452640
Molecular Function	GO:0005515	protein binding	SLC6A4	IPI	UniProtKB:Q9NRD5	Human	PMID:11343649
Molecular Function	GO:0005515	protein binding	SLC6A4	IPI	UniProtKB:O43294	Human	PMID:12177201
Molecular Function	GO:0005515	protein binding	SLC6A4	IPI	UniProtKB:O15127	Human	PMID:16870614
Molecular Function	GO:0005515	protein binding	SLC6A4	IPI	UniProtKB:P37840	Human	PMID:16882008
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	UniProtKB:O54890	Mouse	MGI:MGI:6101340\|PMID:29038237
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	UniProtKB:Q63ZW7\|UniProtKB:Q8R2V9	Mouse	MGI:MGI:3710710\|PMID:17452640
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	UniProtKB:Q3V222	Mouse	MGI:MGI:3710710\|PMID:17452640
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	UniProtKB:Q9Z0J4	Mouse	MGI:MGI:3710710\|PMID:17452640
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	RGD:68348	Rat	PMID:16870614\|RGD:4889520
Molecular Function	GO:0005515	protein binding	Slc6a4	IPI	UniProtKB:Q5U2U4	Rat	PMID:16870614\|RGD:4889520
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	SLC6A4	IDA		Human	PMID:10407194
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	SLC6A4	IMP		Human	PMID:12869649
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	SLC6A4	IDA		Human	PMID:17506858
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	SLC6A4	IDA		Human	PMID:8987735
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Mouse	MGI:MGI:85054\|PMID:9037532
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Rat	PMID:10407194\|RGD:155663546
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Rat	PMID:10716733\|RGD:8554226
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Rat	PMID:11709063\|RGD:8553990
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Rat	PMID:15627510\|RGD:8553308
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IMP		Rat	PMID:15994310\|RGD:1580635
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IDA		Rat	PMID:1944572\|RGD:155663539
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	Slc6a4	IMP		Rat	PMID:8601815\|RGD:155663514
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	slc6a4a	IDA		Zfish	PMID:18266934
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	slc6a4a	IDA		Zfish	PMID:16498236
Molecular Function	GO:0017075	syntaxin-1 binding	Slc6a4	IPI	UniProtKB:P32851	Rat	PMID:11709063\|RGD:8553990
Molecular Function	GO:0017075	syntaxin-1 binding	Slc6a4	IPI	UniProtKB:P32851	Rat	PMID:14642278\|RGD:8553687
Cellular Component	GO:0012505	endomembrane system	SLC6A4	IDA		Human	PMID:17506858
Cellular Component	GO:0012505	endomembrane system	Slc6a4	IDA		Rat	PMID:16870614\|RGD:4889520
Cellular Component	GO:0005925	focal adhesion	Slc6a4	IDA		Mouse	MGI:MGI:6101340\|PMID:29038237
Cellular Component	GO:0045121	membrane raft	SLC6A4	IDA		Human	PMID:16870614
Cellular Component	GO:0045121	membrane raft	Slc6a4	IDA		Rat	PMID:15226315\|RGD:1580636
Cellular Component	GO:0043005	neuron projection	Slc6a4	IDA		Rat	PMID:17310063\|RGD:4889518
Cellular Component	GO:0005886	plasma membrane	SLC6A4	IDA		Human	PMID:12869649
Cellular Component	GO:0005886	plasma membrane	SLC6A4	IDA		Human	PMID:16870614
Cellular Component	GO:0005886	plasma membrane	SLC6A4	IDA		Human	PMID:17506858
Cellular Component	GO:0005886	plasma membrane	Slc6a4	IDA		Rat	PMID:10716733\|RGD:8554226
Cellular Component	GO:0005886	plasma membrane	Slc6a4	IDA		Rat	PMID:11709063\|RGD:8553990
Cellular Component	GO:0005886	plasma membrane	Slc6a4	IDA		Rat	PMID:15627510\|RGD:8553308
Cellular Component	GO:0005886	plasma membrane	Slc6a4	IDA		Rat	PMID:8601815\|RGD:155663514
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a4	IDA		Rat	PMID:10460242\|RGD:13702349
Cellular Component	GO:0098793	presynapse	Slc6a4	IMP		Mouse	MGI:MGI:85054\|PMID:9037532
Cellular Component	GO:0042734	presynaptic membrane	Slc6a4	IDA		Rat	PMID:10460242\|RGD:13702349
Cellular Component	GO:0099154	serotonergic synapse	Slc6a4	IDA		Rat	PMID:10460242\|RGD:13702349
Cellular Component	GO:0045202	synapse	Slc6a4	IDA		Mouse	MGI:MGI:6101340\|PMID:29038237
Cellular Component	GO:0045202	synapse	Slc6a4	IDA		Rat	PMID:11113454\|RGD:38456013
Cellular Component	GO:0045202	synapse	Slc6a4	IDA		Rat	PMID:12590935\|RGD:38549585
Biological Process	GO:0007420	brain development	Slc6a4	IEP		Rat	PMID:20127812\|RGD:4889485
Biological Process	GO:0048854	brain morphogenesis	Slc6a4	IMP		Mouse	MGI:MGI:3832995\|PMID:19208814
Biological Process	GO:0071321	cellular response to cGMP	Slc6a4	IDA		Rat	PMID:17310063\|RGD:4889518
Biological Process	GO:0071310	cellular response to organic substance	Slc6a4	IDA		Mouse	PMID:18794345
Biological Process	GO:0071300	cellular response to retinoic acid	Slc6a4	IEP		Rat	PMID:17895527\|RGD:4889514
Biological Process	GO:0007623	circadian rhythm	Slc6a4	IMP		Rat	PMID:18482738\|RGD:4889508
Biological Process	GO:0007613	memory	Slc6a4	IMP		Rat	PMID:20730799\|RGD:4889470
Biological Process	GO:0015844	monoamine transport	SLC6A4	IDA		Human	PMID:16024787
Biological Process	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation	Slc6a4	IMP		Rat	PMID:18573488\|RGD:4889489
Biological Process	GO:0045665	negative regulation of neuron differentiation	Slc6a4	IMP		Rat	PMID:18573488\|RGD:4889489
Biological Process	GO:0046621	negative regulation of organ growth	Slc6a4	IMP		Mouse	MGI:MGI:3832995\|PMID:19208814
Biological Process	GO:0032227	negative regulation of synaptic transmission, dopaminergic	Slc6a4	IMP		Rat	PMID:20730799\|RGD:4889470
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a4	IDA		Mouse	PMID:9037532
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a4	IMP		Mouse	PMID:9037532
Biological Process	GO:0006836	neurotransmitter transport	Slc6a4	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Biological Process	GO:0045787	positive regulation of cell cycle	Slc6a4	IMP		Mouse	MGI:MGI:4820706\|PMID:19308295
Biological Process	GO:0010628	positive regulation of gene expression	Slc6a4	IMP		Mouse	MGI:MGI:4820706\|PMID:19308295
Biological Process	GO:0014064	positive regulation of serotonin secretion	Slc6a4	IMP		Rat	PMID:25261262\|RGD:11532763
Biological Process	GO:0090067	regulation of thalamus size	SLC6A4	IMP		Human	PMID:18378990
Biological Process	GO:0032355	response to estradiol	Slc6a4	IEP		Rat	PMID:19168037\|RGD:4889488
Biological Process	GO:0001666	response to hypoxia	Slc6a4	IEP		Rat	PMID:11259539\|RGD:4889445
Biological Process	GO:0007584	response to nutrient	Slc6a4	IEP		Rat	PMID:21068163\|RGD:4889469
Biological Process	GO:0010033	response to organic substance	Slc6a4	IEP		Rat	PMID:20002520\|RGD:4889486
Biological Process	GO:0009636	response to toxic substance	SLC6A4	IDA		Human	PMID:17575980
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc6a4	IEP		Rat	PMID:20501324\|RGD:4889472
Biological Process	GO:0006837	serotonin transport	Slc6a4	IMP		Mouse	MGI:MGI:4820706\|PMID:19308295
Biological Process	GO:0006837	serotonin transport	Slc6a4	IDA		Rat	PMID:11709063\|RGD:8553990
Biological Process	GO:0006837	serotonin transport	Slc6a4	IMP		Rat	PMID:15994310\|RGD:1580635
Biological Process	GO:0006837	serotonin transport	slc6a4a	IDA		Zfish	PMID:18266934
Biological Process	GO:0051610	serotonin uptake	SLC6A4	IDA		Human	PMID:16870614
Biological Process	GO:0051610	serotonin uptake	SLC6A4	IDA		Human	PMID:17506858
Biological Process	GO:0051610	serotonin uptake	SLC6A4	IMP		Human	PMID:7681602
Biological Process	GO:0051610	serotonin uptake	SLC6A4	IDA		Human	PMID:8987735
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IDA		Mouse	MGI:MGI:3710710\|PMID:17452640
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IMP		Mouse	MGI:MGI:2178281\|PMID:9547354
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IDA		Rat	PMID:10716733\|RGD:8554226
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IMP		Rat	PMID:12944413\|RGD:1580638
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IDA		Rat	PMID:14642278\|RGD:8553687
Biological Process	GO:0051610	serotonin uptake	Slc6a4	IDA		Rat	PMID:15627510\|RGD:8553308
Biological Process	GO:0035176	social behavior	Slc6a4	IGI	UniProtKB:O08586	Mouse	MGI:MGI:3832995\|PMID:19208814
Biological Process	GO:0042713	sperm ejaculation	Slc6a4	IMP		Rat	PMID:20704641\|RGD:4889471
Biological Process	GO:0042310	vasoconstriction	Slc6a4	IMP		Rat	PMID:14605793\|RGD:4889444

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.