Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH2B3
  • Mouse genes Sh2b3
  • Rat genes Sh2b3
  • Zfish genes sh2b3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh2b3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042301	phosphate ion binding	Sh2b3	IDA		Rat	PMID:8524815|RGD:68272
Molecular Function	GO:0005515	protein binding	SH2B3	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SH2B3	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SH2B3	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2B3	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	Sh2b3	IPI	PR:P05532	Mouse	PMID:11805142
Molecular Function	GO:1990782	protein tyrosine kinase binding	Sh2b3	IPI	UniProtKB:P05532	Mouse	MGI:MGI:3041996|PMID:14612394
Molecular Function	GO:0044877	protein-containing complex binding	Sh2b3	IDA		Rat	PMID:8524815|RGD:68272
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	Sh2b3	IPI	UniProtKB:P05532	Mouse	MGI:MGI:3041996|PMID:14612394
Molecular Function	GO:0005173	stem cell factor receptor binding	Sh2b3	IDA		Mouse	MGI:MGI:3041996|PMID:14612394
Biological Process	GO:1990869	cellular response to chemokine	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0036016	cellular response to interleukin-3	Sh2b3	IDA		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0035162	embryonic hemopoiesis	Sh2b3	IMP		Mouse	PMID:14612394
Biological Process	GO:0035162	embryonic hemopoiesis	Sh2b3	IDA		Mouse	PMID:14612394
Biological Process	GO:0048821	erythrocyte development	SH2B3	IMP		Human	PMID:20404132
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Sh2b3	IMP		Mouse	PMID:14612394
Biological Process	GO:0030097	hemopoiesis	Sh2b3	IMP	MGI:MGI:2180088	Mouse	PMID:11805142
Biological Process	GO:0035556	intracellular signal transduction	Sh2b3	IDA		Mouse	PMID:11805142
Biological Process	GO:0035855	megakaryocyte development	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0035702	monocyte homeostasis	Sh2b3	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5905608|PMID:27430239
Biological Process	GO:0008285	negative regulation of cell population proliferation	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:1900235	negative regulation of Kit signaling pathway	Sh2b3	IMP	GO:1990782	Mouse	MGI:MGI:3041996|PMID:14612394
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0090331	negative regulation of platelet aggregation	Sh2b3	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5905608|PMID:27430239
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Sh2b3	IDA		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	SH2B3	IMP		Human	PMID:20404132
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	SH2B3	IMP		Human	PMID:20404132
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	Sh2b3	IMP		Rat	PMID:25628389|RGD:12904914
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790
Biological Process	GO:0001780	neutrophil homeostasis	Sh2b3	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5905608|PMID:27430239
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Sh2b3	IMP		Rat	PMID:25776069|RGD:13442483
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	SH2B3	IDA		Human	PMID:20404132
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	Sh2b3	IGI	UniProtKB:P35951	Mouse	MGI:MGI:5905608|PMID:27430239
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	Sh2b3	IMP		Mouse	MGI:MGI:3510267|PMID:15337790

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern