Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Scarb1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SCARB1
- Mouse genes Scarb1
- Rat genes Scarb1
- Zfish genes scarb1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scarb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Scarb1	IGI	UniProtKB:P30204	Mouse	MGI:MGI:5902691\|PMID:11240025
Molecular Function	GO:0034186	apolipoprotein A-I binding	SCARB1	IPI	UniProtKB:P02647	Human	PMID:10764676
Molecular Function	GO:0034186	apolipoprotein A-I binding	SCARB1	IPI	UniProtKB:P02647	Human	PMID:12651854
Molecular Function	GO:0034185	apolipoprotein binding	SCARB1	IPI	UniProtKB:P02652	Human	PMID:10764676
Molecular Function	GO:0034185	apolipoprotein binding	Scarb1	IPI	UniProtKB:P02656	Mouse	MGI:MGI:3847879\|PMID:9254056
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Scarb1	IDA		Mouse	MGI:MGI:3047008\|PMID:15210959
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Scarb1	IDA		Mouse	PMID:14729860
Molecular Function	GO:0070506	high-density lipoprotein particle receptor activity	SCARB1	IMP		Human	PMID:11208913
Molecular Function	GO:0070506	high-density lipoprotein particle receptor activity	SCARB1	IDA		Human	PMID:9211901
Molecular Function	GO:0042802	identical protein binding	Scarb1	IPI	RGD:2302	Rat	PMID:14657200\|RGD:1580003
Molecular Function	GO:0001530	lipopolysaccharide binding	SCARB1	IDA		Human	PMID:12651854
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity	SCARB1	IDA		Human	PMID:12651854
Molecular Function	GO:0030169	low-density lipoprotein particle binding	SCARB1	IDA		Human	PMID:9211901
Molecular Function	GO:0001786	phosphatidylserine binding	Scarb1	IDA		Rat	PMID:12016218\|RGD:1304245
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P26663:PRO_0000037570	Human	PMID:12356718
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:12356718
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P60033	Human	PMID:30024968
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P05412	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SCARB1	IPI	UniProtKB:P60033	Human	PMID:32900848
Cellular Component	GO:0005901	caveola	Scarb1	IDA		Mouse	PMID:9148942
Cellular Component	GO:0009986	cell surface	Scarb1	IDA		Mouse	MGI:MGI:5634884\|PMID:21481393
Cellular Component	GO:0009986	cell surface	Scarb1	IDA		Rat	PMID:11882321\|RGD:1304237
Cellular Component	GO:0005737	cytoplasm	Scarb1	IDA		Mouse	MGI:MGI:5634884\|PMID:21481393
Cellular Component	GO:0005737	cytoplasm	Scarb1	IDA		Rat	PMID:11882321\|RGD:1304237
Cellular Component	GO:0070062	extracellular exosome	SCARB1	HDA		Human	PMID:20458337
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SCARB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	SCARB1	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	SCARB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Scarb1	IDA		Mouse	PMID:9148942
Cellular Component	GO:0031528	microvillus membrane	Scarb1	IDA		Rat	PMID:14657200\|RGD:1580003
Cellular Component	GO:0005886	plasma membrane	SCARB1	IDA		Human	PMID:9211901
Cellular Component	GO:0005886	plasma membrane	Scarb1	IDA		Mouse	PMID:9148942
Biological Process	GO:0044406	adhesion of symbiont to host	SCARB1	IMP		Human	PMID:19087225
Biological Process	GO:0006702	androgen biosynthetic process	Scarb1	IDA		Rat	PMID:12746305\|RGD:1304382
Biological Process	GO:0043534	blood vessel endothelial cell migration	Scarb1	IMP	MGI:MGI:1888384	Mouse	PMID:16339487
Biological Process	GO:0046867	carotenoid transport	Scarb1	IMP	MGI:MGI:1888384	Mouse	PMID:25701869
Biological Process	GO:0006707	cholesterol catabolic process	Scarb1	IDA		Mouse	PMID:11278646
Biological Process	GO:0006707	cholesterol catabolic process	Scarb1	IMP	MGI:MGI:1928989	Mouse	PMID:10559220
Biological Process	GO:0033344	cholesterol efflux	SCARB1	IMP		Human	PMID:12202492
Biological Process	GO:0033344	cholesterol efflux	Scarb1	IDA		Mouse	MGI:MGI:3843437\|PMID:14718538
Biological Process	GO:0033344	cholesterol efflux	Scarb1	IMP		Mouse	MGI:MGI:5634884\|PMID:21481393
Biological Process	GO:0042632	cholesterol homeostasis	Scarb1	IMP		Mouse	MGI:MGI:3842875\|PMID:19136670
Biological Process	GO:0070508	cholesterol import	SCARB1	IMP		Human	PMID:11208913
Biological Process	GO:0070508	cholesterol import	SCARB1	IMP		Human	PMID:26965621
Biological Process	GO:0070508	cholesterol import	Scarb1	IDA		Mouse	MGI:MGI:3843437\|PMID:14718538
Biological Process	GO:0070508	cholesterol import	Scarb1	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0070508	cholesterol import	Scarb1	IMP		Mouse	MGI:MGI:5634884\|PMID:21481393
Biological Process	GO:0030301	cholesterol transport	Scarb1	IDA		Mouse	PMID:14729860
Biological Process	GO:0030301	cholesterol transport	Scarb1	IDA		Mouse	PMID:8753864
Biological Process	GO:0030301	cholesterol transport	Scarb1	IMP	MGI:MGI:1928989	Mouse	PMID:10559220
Biological Process	GO:0032497	detection of lipopolysaccharide	SCARB1	IDA		Human	PMID:12651854
Biological Process	GO:0001935	endothelial cell proliferation	Scarb1	IMP	MGI:MGI:1888384	Mouse	PMID:16339487
Biological Process	GO:0034384	high-density lipoprotein particle clearance	SCARB1	IDA		Human	PMID:23459944
Biological Process	GO:0034384	high-density lipoprotein particle clearance	SCARB1	IDA		Human	PMID:9211901
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	Scarb1	IMP		Mouse	MGI:MGI:3056693\|PMID:15210842
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	Scarb1	IMP		Mouse	MGI:MGI:5634884\|PMID:21481393
Biological Process	GO:0098856	intestinal lipid absorption	Scarb1	IMP	MGI:MGI:1888384	Mouse	PMID:25701869
Biological Process	GO:0006869	lipid transport	Scarb1	IMP		Rat	PMID:12032160\|RGD:1580002
Biological Process	GO:0015920	lipopolysaccharide transport	SCARB1	IDA		Human	PMID:12651854
Biological Process	GO:0034383	low-density lipoprotein particle clearance	Scarb1	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0006910	phagocytosis, recognition	Scarb1	IMP		Rat	PMID:12016218\|RGD:1304245
Biological Process	GO:0015914	phospholipid transport	Scarb1	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0010886	positive regulation of cholesterol storage	SCARB1	IDA		Human	PMID:9211901
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	SCARB1	IDA		Human	PMID:11792700
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Scarb1	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0043654	recognition of apoptotic cell	SCARB1	IDA		Human	PMID:9211901
Biological Process	GO:0043654	recognition of apoptotic cell	Scarb1	IDA		Rat	PMID:12016218\|RGD:1304245
Biological Process	GO:0050764	regulation of phagocytosis	Scarb1	IDA		Rat	PMID:12016218\|RGD:1304245
Biological Process	GO:0010899	regulation of phosphatidylcholine catabolic process	Scarb1	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0043691	reverse cholesterol transport	SCARB1	IEP		Human	PMID:9211901
Biological Process	GO:0043691	reverse cholesterol transport	Scarb1	IMP		Mouse	MGI:MGI:3842875\|PMID:19136670
Biological Process	GO:0070328	triglyceride homeostasis	Scarb1	IMP		Mouse	MGI:MGI:3842875\|PMID:19136670
Biological Process	GO:0035461	vitamin transmembrane transport	SCARB1	IMP		Human	PMID:11208913

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.