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Scarb1
Gene Detail
Symbol

Name
ID
Scarb1
scavenger receptor class B, member 1
MGI:893578
Synonyms
Cd36l1, Cla-1, D5Ertd460e, Hdlq1, Hlb398, Srb1, SRBI, SR-BI
Feature Type
protein coding gene
Genetic Map
Chromosome 5
64.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr5:125277087-125341094 bp, - strand
From VEGA annotation of GRCm38

  64008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lysosomal integral membrane protein II
Gene Tree: Scarb1

Human
homologs
Human Homolog SCARB1, scavenger receptor class B, member 1
NCBI Gene ID 949
neXtProt AC  NX_Q8WTV0
Human Synonyms  CD36L1, CLA1, CLA-1, HDLQTL6, SRB1, SR-BI
Human Chr (Location)  12q24.31; chr12:124777628-124863973 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(6) QTL(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutations result in abnormal lipoprotein metablolism and, for one allele, reversible female infertility. An ENU mutant shows increased cholesterol levels.
 
Interactions
Scarb1 interacts with 156 markers (Mir15a, Mir16-1, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process adhesion of symbiont to host, androgen biosynthetic process, ...
Component caveola, cell surface, ...
Function apolipoprotein A-I binding, apolipoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (126)    Tissues (41)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
RT-PCR 44
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022742 (Evidence)
Ensembl Gene ModelENSMUSG00000037936 (Evidence)
Entrez Gene20778 (Evidence)
DFCITC1589927, TC1590445, TC1572096, TC1739182
DoTSDT.97344626, DT.94407273, DT.536072, DT.94407272, DT.97392173
NIA Mouse Gene IndexU026741
PDB3R69
Consensus CDS ProjectCCDS19683.1, CCDS57383.1
International Mouse Knockout Project StatusScarb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022742 VEGA Gene Model | MGI Sequence Detail 64008 C57BL/6J ±  kb
transcript OTTMUST00000054565 VEGA | MGI Sequence Detail 2521 Not Applicable 
polypeptide OTTMUSP00000026063 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(10) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005428 Adhesion molecule CD36
InterPro IPR002159 CD36 antigen
Protein Ontology PR:000014493 scavenger receptor class B member 1
References
(Earliest) J:37371 Acton SL, et al., Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem. 1994 Aug 19;269(33):21003-9
(Latest) J:214115 Guo L, et al., Hepatic scavenger receptor BI protects against polymicrobial-induced sepsis through promoting LPS clearance in mice. J Biol Chem. 2014 May 23;289(21):14666-73
All references(206)
Other
accession IDs
MGI:1196331, MGI:2140809, MGI:2387134, MGI:3575156

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory