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Scarb1 Gene Detail
Summary
  • Symbol
    Scarb1
  • Name
    scavenger receptor class B, member 1
  • Synonyms
    Cd36l1, Chohd1, Chohd1, Cla-1, D5Ertd460e, Hdlq1, Hlb398, Srb1, SRBI, SR-BI
  • Feature Type
    protein coding gene
  • IDs
    MGI:893578
    NCBI Gene: 20778
  • Gene Overview
    MyGene.info: SCARB1
Location & Maps
more
  • Sequence Map
    Chr5:125277087-125341094 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 64.11 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    SCARB1, scavenger receptor class B member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SCARB1, scavenger receptor class B member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD36L1, CLA1, CLA-1, HDLQTL6, SRB1, SR-BI
  • Links
    NCBI Gene ID: 949
    neXtProt AC: NX_Q8WTV0

  • Chr Location
    12q24.31; chr12:124777628-124863973 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 10 alleles in 12 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • QTL
    4
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    3
  • Genomic Mutations
    2 involving Scarb1
  • Incidental Mutations
Targeted mutations result in abnormal lipoprotein metablolism and, for one allele, reversible female infertility. An ENU mutant shows increased cholesterol levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022742 VEGA Gene Model | MGI Sequence Detail 64008 C57BL/6J ±  kb
transcript OTTMUST00000054565 VEGA | MGI Sequence Detail 2521 Not Applicable  
polypeptide OTTMUSP00000026063 VEGA | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    254 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014493 scavenger receptor class B member 1
  • PDB
  • InterPro Domains
    IPR002159 CD36 family
    IPR005428 CD36/scavenger receptor class B member 1
Molecular
Reagents
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  • All nucleic 24
    cDNA 21
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1196331, MGI:2140809, MGI:2387134, MGI:3513270, MGI:3575156
References
more
  • Summaries
    All 218
    Developmental Gene Expression 19
    Gene Ontology 19
    Phenotypes 133
  • Earliest
    J:37371 Acton SL, et al., Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem. 1994 Aug 19;269(33):21003-9
  • Latest
    J:228657 Lino M, et al., Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G350-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory