Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse S1pr2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes S1PR2
- Mouse genes S1pr2
- Rat genes S1pr2
- Zfish genes s1pr2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S1pr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	S1PR2	IPI	UniProtKB:Q7Z5A7	Human	PMID:29453251
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	S1pr2	IDA		Rat	PMID:29453251\|RGD:42721986
Molecular Function	GO:0004930	G protein-coupled receptor activity	S1pr2	IDA		Rat	PMID:9409733\|RGD:632521
Molecular Function	GO:0001664	G protein-coupled receptor binding	S1PR2	IPI	UniProtKB:P21453	Human	PMID:24851274
Molecular Function	GO:0005178	integrin binding	S1PR2	IPI	UniProtKB:P16144	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	S1PR2	IPI	UniProtKB:Q9JK11-1	Human	PMID:24453941
Molecular Function	GO:0005515	protein binding	S1PR2	IPI	UniProtKB:P16144	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	S1pr2	IPI	UniProtKB:Q99P72\|UniProtKB:Q9JK11-1	Mouse	MGI:MGI:5563306\|PMID:24453941
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	S1PR2	IMP		Human	PMID:23106337
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	S1PR2	IDA		Human	PMID:29453251
Cellular Component	GO:0005886	plasma membrane	S1PR2	IDA		Human	PMID:24851274
Cellular Component	GO:0005886	plasma membrane	S1PR2	IDA		Human	PMID:29453251
Biological Process	GO:0031532	actin cytoskeleton reorganization	S1PR2	IMP		Human	PMID:23106337
Biological Process	GO:0048901	anterior lateral line neuromast development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24176858
Biological Process	GO:0035676	anterior lateral line neuromast hair cell development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24176858
Biological Process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	s1pr2	IMP	ZFIN:ZDB-GENO-140411-5	Zfish	PMID:23951404
Biological Process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	s1pr2	IGI	ZFIN:ZDB-GENO-140411-5,ZFIN:ZDB-MRPHLNO-050620-2	Zfish	PMID:23951404
Biological Process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	s1pr2	IGI	ZFIN:ZDB-GENO-130530-5,ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:23951404
Biological Process	GO:0042074	cell migration involved in gastrulation	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:18701549
Biological Process	GO:0042074	cell migration involved in gastrulation	s1pr2	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0060973	cell migration involved in heart development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:23318642
Biological Process	GO:0060973	cell migration involved in heart development	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:23318642
Biological Process	GO:0003318	cell migration to the midline involved in heart development	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:25997406
Biological Process	GO:0060026	convergent extension	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:23318642
Biological Process	GO:0060027	convergent extension involved in gastrulation	s1pr2	IDA		Zfish	PMID:19062281
Biological Process	GO:0035050	embryonic heart tube development	s1pr2	IMP	ZFIN:ZDB-TALEN-131219-2	Zfish	PMID:23616919
Biological Process	GO:0035050	embryonic heart tube development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:23616919
Biological Process	GO:0003143	embryonic heart tube morphogenesis	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24451492
Biological Process	GO:0003143	embryonic heart tube morphogenesis	s1pr2	IGI	ZFIN:ZDB-GENE-040426-1156,ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24451492
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	s1pr2	IGI	ZFIN:ZDB-GENO-140411-5,ZFIN:ZDB-MRPHLNO-050620-2	Zfish	PMID:23951404
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	s1pr2	IGI	ZFIN:ZDB-GENO-130530-5,ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:23951404
Biological Process	GO:0007492	endoderm development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:23318642
Biological Process	GO:0007492	endoderm development	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:23318642
Biological Process	GO:0060079	excitatory postsynaptic potential	S1pr2	IMP	MGI:MGI:2180817	Mouse	PMID:11553273
Biological Process	GO:0046847	filopodium assembly	S1PR2	IMP		Human	PMID:23106337
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	S1PR2	IDA		Human	PMID:29453251
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	S1pr2	IDA		Rat	PMID:29453251\|RGD:42721986
Biological Process	GO:0007507	heart development	s1pr2	IMP	ZFIN:ZDB-GENO-980202-969	Zfish	PMID:17537802
Biological Process	GO:0003007	heart morphogenesis	s1pr2	IMP	ZFIN:ZDB-GENO-980202-969	Zfish	PMID:9007249
Biological Process	GO:0003007	heart morphogenesis	s1pr2	IGI	ZFIN:ZDB-GENO-070911-2,ZFIN:ZDB-MRPHLNO-070911-2	Zfish	PMID:17230219
Biological Process	GO:0003007	heart morphogenesis	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:9007249
Biological Process	GO:0003007	heart morphogenesis	s1pr2	IMP	ZFIN:ZDB-GENO-070911-2	Zfish	PMID:17230219
Biological Process	GO:0003315	heart rudiment formation	s1pr2	IGI	ZFIN:ZDB-GENO-010411-9,ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:25555130
Biological Process	GO:0003315	heart rudiment formation	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:25555130
Biological Process	GO:0008078	mesodermal cell migration	s1pr2	IGI	ZFIN:ZDB-GENO-070911-1,ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:18701549
Biological Process	GO:0030336	negative regulation of cell migration	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:18701549
Biological Process	GO:0030336	negative regulation of cell migration	s1pr2	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	S1pr2	IMP	MGI:MGI:2180817	Mouse	PMID:11553273
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	S1pr2	IGI	RGD:1562115	Rat	PMID:29453251\|RGD:42721986
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	S1pr2	IGI	RGD:1562115	Rat	PMID:29453251\|RGD:42721986
Biological Process	GO:0048840	otolith development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24176858
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	S1PR2	IMP		Human	PMID:24851274
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	S1PR2	IMP		Human	PMID:23106337
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	S1pr2	IMP		Mouse	MGI:MGI:5470025\|PMID:23106337
Biological Process	GO:0035677	posterior lateral line neuromast hair cell development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24176858
Biological Process	GO:0061035	regulation of cartilage development	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:22185793
Biological Process	GO:0060872	semicircular canal development	s1pr2	IMP	ZFIN:ZDB-MRPHLNO-070911-3	Zfish	PMID:24176858
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	S1PR2	IMP		Human	PMID:23106337
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	S1pr2	IMP		Mouse	MGI:MGI:5470025\|PMID:23106337
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	s1pr2	IMP	ZFIN:ZDB-GENO-010411-9	Zfish	PMID:22185793
Biological Process	GO:0001944	vasculature development	s1pr2	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:23229546

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.