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S1pr2 Gene Detail
Summary
  • Symbol
    S1pr2
  • Name
    sphingosine-1-phosphate receptor 2
  • Synonyms
    1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99569
    NCBI Gene: 14739
  • Gene Overview
    MyGene.info: S1PR2
Location & Maps
more
  • Sequence Map
    Chr9:20965952-20976793 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.68 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGR16, DFNB68, EDG5, EDG-5, Gpcr13, H218, LPB2, S1P2
  • Links
    NCBI Gene ID: 9294
    neXtProt AC: NX_O95136

  • Chr Location
    19p13.2; chr19:10221433-10231807 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human S1PR2 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 68; DFNB68   OMIM: 610419
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    30 phenotypes from multigenic genotypes
    8 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Gene trapped
    55
  • Targeted
    10
  • Incidental Mutations
Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14739 NCBI Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
transcript NM_010333 RefSeq | MGI Sequence Detail 2815 C57BL/6  
polypeptide P52592 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001707 sphingosine 1-phosphate receptor 2
  • InterPro Domains
    IPR004063 EDG-5 sphingosine 1-phosphate receptor
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR004061 Sphingosine 1-phosphate receptor
Molecular
Reagents
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  • All nucleic 93
    cDNA 90
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16349, MGI:1915680
References
more
  • Summaries
    All 107
    Developmental Gene Expression 19
    Gene Ontology 6
    Phenotypes 52
  • Earliest
    J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
  • Latest
    J:231927 Santos-Cortez RL, et al., Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. Am J Hum Genet. 2016 Feb 4;98(2):331-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory