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S1pr2
Gene Detail
 Symbol
Name
ID
S1pr2
sphingosine-1-phosphate receptor 2
MGI:99569
Synonyms 1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:20965952-20976793 bp, - strand
From NCBI annotation of GRCm38

  10842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3118  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr2

Human
homologs
Human Homolog S1PR2, sphingosine-1-phosphate receptor 2
NCBI Gene ID 9294
neXtProt AC  NX_O95136
Human Synonyms  AGR16, EDG5, EDG-5, Gpcr13, H218, LPB2, S1P2
Human Chr (Location)  19p13.2; chr19:10221433-10231272 (-)  GRCh38
Alleles
and
phenotypes
All alleles(64) : Gene trapped(55) Targeted(9)
 
Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth.
 
Phenotype Images(8)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of excitatory postsynaptic membrane potential, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, G-protein coupled receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (137)    Tissues (85)    Images (43)
Theiler Stages: 11, 13, 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 124
RT-PCR 13
cDNA source data(89)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(93) cDNA(90) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000043895 (Evidence)
Entrez Gene14739 (Evidence)
UniGene46493
DFCITC1575097
DoTSDT.97375057
NIA Mouse Gene IndexU030565
Consensus CDS ProjectCCDS22888.1
International Mouse Knockout Project StatusS1pr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14739 NCBI Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
transcript NM_010333 RefSeq | MGI Sequence Detail 2815 C57BL/6 
polypeptide P52592 UniProt | EBI | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004063 EDG-5 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001707 sphingosine 1-phosphate receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:208445 Kempf A, et al., The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol. 2014 Jan;12(1):e1001763
All references(101)
Other
accession IDs
MGD-MRK-16349, MGI:1915680

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory