S1pr2
Gene Detail

Symbol Name ID

S1pr2 sphingosine-1-phosphate receptor 2 MGI:99569

Synonyms

1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:20965952-20976793 bp, - strand From NCBI annotation of GRCm38   10842 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3118  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr2

Human homologs

Human Homolog		S1PR2, sphingosine-1-phosphate receptor 2
NCBI Gene ID		9294
neXtProt AC		NX_O95136
Human Synonyms		AGR16, EDG5, EDG-5, Gpcr13, H218, LPB2, S1P2
Human Chr (Location)		19p13.2; chr19:10332109-10341948 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(64) : Targeted(9) Gene trapped(55)
 

Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth.

 
Phenotype Images(8)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of excitatory postsynaptic membrane potential, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (85)    Tissues (58)    Images (29)
Theiler Stages: 11, 13, 15, 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	72
RT-PCR	13

cDNA source data(88)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(91) cDNA(89) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000043895 (Evidence)
Entrez Gene	14739 (Evidence)
UniGene	46493
DFCI	TC1575097
DoTS	DT.97375057
NIA Mouse Gene Index	U030565
Consensus CDS Project	CCDS22888.1
International Mouse Knockout Project Status	S1pr2

Sequences

Length	Strain/Species
genomic	14739	NCBI Gene Model | MGI Sequence Detail	10842	C57BL/6J
transcript	NM_010333	RefSeq | MGI Sequence Detail	2815	C57BL/6
polypeptide	P52592	UniProt | EBI | MGI Sequence Detail	352	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004063	EDG-5 sphingosine 1-phosphate receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR004061	Sphingosine 1-phosphate receptor
Protein Ontology	PR:000001707	sphingosine 1-phosphate receptor 2

Graphical View of Protein Domain Structure

References

(Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:194000 Gandy KA, et al., Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 1;449(3):661-72
All references(96)

Other accession IDs

MGD-MRK-16349, MGI:1915680