S1pr2^tm1Ajml
Targeted Allele Detail

Summary

• Symbol: S1pr2^tm1Ajml
• Name: sphingosine-1-phosphate receptor 2; targeted mutation 1, A John MacLennan
• MGI ID: MGI:2180817
• Synonyms: H218-, S1P2^-
• Gene: S1pr2 Location: Chr9:20877248-20888089 bp, - strand Genetic Position: Chr9, 7.68 cM
• Alliance: S1pr2^tm1Ajml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73957
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of an IRES Beta-galactosidase/MC1-neomycin resistance cassette replaced the entire open reading frame including the start codon. RT-PCR studies did not detect transcript in embryonic, 4-week, or adult brain tissue from homozygous mutant mice. (J:73957)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S1pr2 Mutation: 46 strains or lines available

Notes

All animals used in J:73957 were derived from F1, F2 or F3 heterozygous crosses.

References

• Original: J:73957 MacLennan AJ, et al., An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci. 2001 Jul;14(2):203-9
• All: 6 reference(s)