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S1pr2 Gene Detail
Summary
  • Symbol
    S1pr2
  • Name
    sphingosine-1-phosphate receptor 2
  • Synonyms
    1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99569
    NCBI Gene: 14739
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:20877248-20888089 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99569
 protein coding gene Chr9:20873657-20888089 (-)
129S1/SvImJ ENSMUSG00200049137
 protein coding gene Chr9:17827364-17841766 (-)
A/J ENSMUSG00195037742
 protein coding gene Chr9:17664162-17678586 (-)
AKR/J ENSMUSG00220026937
 protein coding gene Chr9:17666622-17681042 (-)
BALB/cJ ENSMUSG00180036500
 protein coding gene Chr9:17798466-17812889 (-)
C3H/HeJ ENSMUSG00175037725
 protein coding gene Chr9:17760813-17775233 (-)
C57BL/6NJ ENSMUSG00215031320
 protein coding gene Chr9:17758342-17772762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031853
 protein coding gene Chr9:16966304-16977171 (-)
CAST/EiJ ENSTCUG00005027833
 protein coding gene Chr9:17792471-17807002 (-)
CBA/J ENSMUSG00210036408
 protein coding gene Chr9:17741685-17756093 (-)
DBA/2J ENSMUSG00185026405
 protein coding gene Chr9:17857320-17871736 (-)
FVB/NJ ENSMUSG00205033086
 protein coding gene Chr9:18090106-18104508 (-)
JF1/MsJ ENSUMUG00000014134
 protein coding gene Chr9:17961419-17975863 (-)
LP/J ENSMUSG00230038699
 protein coding gene Chr9:18248702-18263124 (-)
NOD/ShiLtJ ENSMUSG00190034054
 protein coding gene Chr9:17782145-17796549 (-)
NZO/HlLtJ ENSMUSG00225050868
 protein coding gene Chr9:18199062-18213458 (-)
PWK/PhJ ENSLUMG00010038578
 protein coding gene Chr9:17850608-17865093 (-)
SPRET/EiJ ENSMSPG00010021134
 protein coding gene Chr9:18089781-18127548 (-)
WSB/EiJ ENSIUOG00005042526
 protein coding gene Chr9:17328987-17343396 (-)



Homology
more
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR2, sphingosine-1-phosphate receptor 2
  • Synonyms
    AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2
  • Links
    NCBI Gene ID: 9294
    UniProt: O95136

  • Chr Location
    19p13.2; chr19:10221433-10231331 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with S1pr2 mouse models; 1 with human S1PR2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 7 alleles in 9 genetic backgrounds
    30 phenotypes from multigenic genotypes
    8 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    111
  • cDNA Data
    92
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14739 NCBI Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
    transcript NM_010333 RefSeq | MGI Sequence Detail 2815 ZRU/MplStud  
    polypeptide P52592 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 94
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16349, MGI:1915680
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 25
      Diseases 3
      Gene Ontology 14
      Phenotypes 91
    • Earliest
      J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
    • Latest
      J:389429 Xiao B, et al., MAP3K1 integrates RhoA/ROCK signaling to regulate epithelial morphogenesis. iScience. 2026 Jun 19;29(6):115853
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory