Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RUVBL2
  • Mouse genes Ruvbl2
  • Rat genes Ruvbl2
  • Zfish genes ruvbl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ruvbl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	Ruvbl2	IDA		Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0005524	ATP binding	Ruvbl2	IDA		Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0016887	ATP hydrolysis activity	RUVBL2	IDA		Human	PMID:10966108
Molecular Function	GO:0016887	ATP hydrolysis activity	RUVBL2	IMP		Human	PMID:33205750
Molecular Function	GO:0016887	ATP hydrolysis activity	RUVBL2	IDA		Human	PMID:33367824
Molecular Function	GO:0016887	ATP hydrolysis activity	ruvbl2	IDA		Zfish	PMID:12464178
Molecular Function	GO:0051117	ATPase binding	Ruvbl2	IPI	UniProtKB:P60122	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0008013	beta-catenin binding	RUVBL2	IDA		Human	PMID:11080158
Molecular Function	GO:0031490	chromatin DNA binding	RUVBL2	IDA		Human	PMID:23637611
Molecular Function	GO:0003678	DNA helicase activity	RUVBL2	IDA		Human	PMID:10524211
Molecular Function	GO:0042802	identical protein binding	RUVBL2	IDA		Human	PMID:10966108
Molecular Function	GO:0042802	identical protein binding	RUVBL2	IPI	UniProtKB:Q9Y230	Human	PMID:10966108
Molecular Function	GO:0042802	identical protein binding	RUVBL2	IPI	UniProtKB:Q9Y230	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	RUVBL2	IPI	UniProtKB:Q9Y230	Human	PMID:22748767
Molecular Function	GO:0140585	promoter-enhancer loop anchoring activity	RUVBL2	IMP		Human	PMID:23637611
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:10966108
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:11080158
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9BVM2	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:16230350
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q96L91	Human	PMID:16601686
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y2X3	Human	PMID:17636026
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:P25490	Human	PMID:18026119
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:18087039
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:18358808
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:P38935	Human	PMID:19299493
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8NEU8|UniProtKB:Q9UKG1	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:20371770
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9H6T3,UniProtKB:Q9NWS0,UniProtKB:Q9UBK9,UniProtKB:Q9Y265,UniProtKB:Q9Y4R8	Human	PMID:20864032
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8IW40	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9BVM2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:P25490	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:P25490	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q96L91	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9BVM2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9UHR6	Human	PMID:28561026
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:29323271
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:O75800	Human	PMID:29601588
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8BPA8	Human	PMID:29959317
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9BVM2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9UDY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q14147	Human	PMID:33205750
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q96Q15	Human	PMID:33205750
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q9Y265	Human	PMID:33205750
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:Q8N5I9,UniProtKB:Q9Y265,UniProtKB:Q9Y2X3	Human	PMID:33367824
Molecular Function	GO:0005515	protein binding	RUVBL2	IPI	UniProtKB:P25490	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:Q9CQJ2,UniProtKB:Q9DC40	Mouse	MGI:MGI:4836761|PMID:20864032
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:P22087|UniProtKB:Q9UHK0	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:P60122	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:P60122	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:P55769|UniProtKB:Q9NWK9	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0005515	protein binding	Ruvbl2	IPI	UniProtKB:P60122	Mouse	MGI:MGI:6198825|PMID:29959317
Molecular Function	GO:0042803	protein homodimerization activity	Ruvbl2	IPI	UniProtKB:Q9WTM5	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	RUVBL2	IDA		Human	PMID:23637611
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	RUVBL2	IDA		Human	PMID:23637611
Molecular Function	GO:0017025	TBP-class protein binding	RUVBL2	IDA		Human	PMID:11080158
Molecular Function	GO:0001094	TFIID-class transcription factor complex binding	Ruvbl2	IPI	UniProtKB:Q16594	Mouse	MGI:MGI:5700302|PMID:17636026
Molecular Function	GO:0003714	transcription corepressor activity	RUVBL2	IDA		Human	PMID:11080158
Cellular Component	GO:0005813	centrosome	RUVBL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	RUVBL2	IDA		Human	PMID:19433865
Cellular Component	GO:0005829	cytosol	RUVBL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000791	euchromatin	RUVBL2	IDA		Human	PMID:23637611
Cellular Component	GO:0070062	extracellular exosome	RUVBL2	HDA		Human	PMID:20458337
Cellular Component	GO:0031011	Ino80 complex	RUVBL2	IDA		Human	PMID:21303910
Cellular Component	GO:0031011	Ino80 complex	RUVBL2	IDA		Human	PMID:18026119
Cellular Component	GO:0071339	MLL1 complex	RUVBL2	IDA		Human	PMID:15960975
Cellular Component	GO:0035267	NuA4 histone acetyltransferase complex	RUVBL2	IDA		Human	PMID:27153538
Cellular Component	GO:0035267	NuA4 histone acetyltransferase complex	RUVBL2	IDA		Human	PMID:10966108
Cellular Component	GO:0035267	NuA4 histone acetyltransferase complex	RUVBL2	IDA		Human	PMID:14966270
Cellular Component	GO:0005654	nucleoplasm	RUVBL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000786	nucleosome	RUVBL2	IDA		Human	PMID:27153538
Cellular Component	GO:0005634	nucleus	RUVBL2	IDA		Human	PMID:10524211
Cellular Component	GO:0005634	nucleus	RUVBL2	IDA		Human	PMID:18026119
Cellular Component	GO:0005634	nucleus	RUVBL2	IDA		Human	PMID:19433865
Cellular Component	GO:0101031	protein folding chaperone complex	RUVBL2	IPI		Human	PMID:29844425
Cellular Component	GO:0097255	R2TP complex	RUVBL2	IPI		Human	PMID:29662061
Cellular Component	GO:0097255	R2TP complex	RUVBL2	IDA		Human	PMID:26711270
Cellular Component	GO:0097255	R2TP complex	RUVBL2	IDA		Human	PMID:33367824
Cellular Component	GO:1990904	ribonucleoprotein complex	Ruvbl2	IDA		Mouse	PMID:19299493
Cellular Component	GO:1990062	RPAP3/R2TP/prefoldin-like complex	RUVBL2	IPI		Human	PMID:31738558
Cellular Component	GO:0000812	Swr1 complex	RUVBL2	IDA		Human	PMID:24463511
Biological Process	GO:0070286	axonemal dynein complex assembly	ruvbl2	IMP	ZFIN:ZDB-GENO-130926-1	Zfish	PMID:23858445
Biological Process	GO:0071392	cellular response to estradiol stimulus	RUVBL2	IMP		Human	PMID:23637611
Biological Process	GO:0034644	cellular response to UV	RUVBL2	IMP		Human	PMID:18026119
Biological Process	GO:0006338	chromatin remodeling	RUVBL2	IDA		Human	PMID:21303910
Biological Process	GO:0006338	chromatin remodeling	RUVBL2	IMP		Human	PMID:23637611
Biological Process	GO:0048565	digestive tract development	ruvbl2	IMP	ZFIN:ZDB-GENO-110617-3	Zfish	PMID:12464178
Biological Process	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	ruvbl2	IMP	ZFIN:ZDB-GENO-130926-1	Zfish	PMID:23858445
Biological Process	GO:0071169	establishment of protein localization to chromatin	RUVBL2	IMP		Human	PMID:23637611
Biological Process	GO:0007507	heart development	ruvbl2	IMP	ZFIN:ZDB-GENO-110617-3	Zfish	PMID:12464178
Biological Process	GO:0043968	histone H2A acetylation	RUVBL2	IDA		Human	PMID:27153538
Biological Process	GO:0043967	histone H4 acetylation	RUVBL2	IDA		Human	PMID:27153538
Biological Process	GO:0044458	motile cilium assembly	ruvbl2	IGI	ZFIN:ZDB-MRPHLNO-080929-4,ZFIN:ZDB-MRPHLNO-130923-1	Zfish	PMID:23858445
Biological Process	GO:0044458	motile cilium assembly	ruvbl2	IMP	ZFIN:ZDB-GENO-130926-1	Zfish	PMID:23858445
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	RUVBL2	IDA		Human	PMID:11080158
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ruvbl2	IDA		Zfish	PMID:12464178|ZFIN:ZDB-PUB-021204-1
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ruvbl2	IDA		Zfish	PMID:12464178
Biological Process	GO:0045739	positive regulation of DNA repair	Ruvbl2	IDA		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RUVBL2	IMP		Human	PMID:27641337
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	RUVBL2	IDA		Human	PMID:27153538
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	RUVBL2	HMP		Human	PMID:25467444
Biological Process	GO:1904507	positive regulation of telomere maintenance in response to DNA damage	Ruvbl2	IMP		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUVBL2	IMP		Human	PMID:23637611
Biological Process	GO:0051726	regulation of cell cycle	RUVBL2	IMP		Human	PMID:26340092
Biological Process	GO:0051726	regulation of cell cycle	RUVBL2	IMP		Human	PMID:27153538
Biological Process	GO:0033044	regulation of chromosome organization	RUVBL2	IMP		Human	PMID:26340092
Biological Process	GO:0006282	regulation of DNA repair	Ruvbl2	IDA		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0006275	regulation of DNA replication	RUVBL2	IMP		Human	PMID:25016522
Biological Process	GO:0060382	regulation of DNA strand elongation	RUVBL2	IMP		Human	PMID:25016522
Biological Process	GO:0045995	regulation of embryonic development	Ruvbl2	IMP		Mouse	MGI:MGI:5638510|PMID:23979016
Biological Process	GO:0060420	regulation of heart growth	ruvbl2	IMP	ZFIN:ZDB-GENO-110617-3	Zfish	PMID:12464178
Biological Process	GO:0000723	telomere maintenance	Ruvbl2	IMP		Mouse	MGI:MGI:5638510|PMID:23979016

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern