Ruvbl2 MGI Mouse Gene Detail - MGI:1342299

Symbol

Ruvbl2
Name

RuvB-like protein 2
Synonyms

mp47, p47

Feature Type

protein coding gene
IDs

MGI:1342299
NCBI Gene: 20174
Gene Overview

MyGene.info: RUVBL2
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:45421896-45435332 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.30 cM, cytoband B2
Mapping Data

1 experiment

SNPs within 2kb

84 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342299	protein coding gene	Chr7:45421760-45438096 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032221	protein coding gene	Chr7:45677846-45694167 (-)
A/J	MGP_AJ_G0032200	protein coding gene	Chr7:44808531-44824773 (-)
AKR/J	MGP_AKRJ_G0032136	protein coding gene	Chr7:46051422-46067666 (-)
BALB/cJ	MGP_BALBcJ_G0032212	protein coding gene	Chr7:44797504-44813782 (-)
C3H/HeJ	MGP_C3HHeJ_G0031928	protein coding gene	Chr7:46530665-46547979 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032704	protein coding gene	Chr7:47948311-47964549 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029718	protein coding gene	Chr7:47359324-47375197 (-)
CAST/EiJ	MGP_CASTEiJ_G0031256	protein coding gene	Chr7:37942435-37960423 (-)
CBA/J	MGP_CBAJ_G0031892	protein coding gene	Chr7:49529475-49545701 (-)
DBA/2J	MGP_DBA2J_G0032050	protein coding gene	Chr7:44470987-44487271 (-)
FVB/NJ	MGP_FVBNJ_G0032001	protein coding gene	Chr7:44256573-44272819 (-)
LP/J	MGP_LPJ_G0032128	protein coding gene	Chr7:46379127-46396862 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032038	protein coding gene	Chr7:48232023-48249477 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032720	protein coding gene	Chr7:45264303-45280565 (-)
PWK/PhJ	MGP_PWKPhJ_G0030979	protein coding gene	Chr7:37845803-37862141 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030816	protein coding gene	Chr7:33272927-33289123 (-)
WSB/EiJ	MGP_WSBEiJ_G0031373	protein coding gene	Chr7:45758960-45775586 (-)

Human Ortholog

RUVBL2, RuvB like AAA ATPase 2

Vertebrate Orthologs

9

Human Ortholog

RUVBL2, RuvB like AAA ATPase 2
Orthology source: HomoloGene, HGNC
Synonyms

CGI-46, ECP51, ECP-51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B
Links

HGNC:10475

NCBI Gene ID: 10856

neXtProt AC: NX_Q9Y230

UniProt: Q9Y230
Chr Location

19q13.33; chr19:48993448-49015995 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4856
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RUVBL2
Protein SuperFamily

conserved hypothetical protein YDR190c
Gene Tree

Ruvbl2

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.

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All GO Annotations

57
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

57
Tissues

33
cDNA Data

142
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ruvbl2

ZFIN ruvbl2

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Ruvbl2 interacts with 25 markers (Mir27a, Mir27b, Mir128-1, ...) View All

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All Sequences

78
RefSeq

6
UniProt

8
CCDS

CCDS21243.1
UniGene

34410

Ensembl

ENSMUSG00000003868 (Evidence)
NCBI Gene

20174

			Length	Strain/Species	Flank
genomic	20174	NCBI Gene Model \| MGI Sequence Detail	13437	C57BL/6J	± kb
transcript	NM_011304	RefSeq \| MGI Sequence Detail	1675	C57BL/6
polypeptide	Q9WTM5	UniProt \| EBI \| MGI Sequence Detail	463	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014369 RuvB-like 2

(term hierarchy)
EC

3.6.4.12
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR027238 RuvB-like

IPR041048 RuvB-like, AAA-lid domain

IPR037942 RuvB-like helicase 2

IPR042487 RuvB-like helicase 2, domain II

IPR010339 TIP49, P-loop domain

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All nucleic 142

cDNA 142

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 6
Earliest

J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
Latest

J:228312 Tarangelo A, et al., Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028

TSS for Ruvbl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72389	Chr7:45434590-45434646 (-)	714 bp
Tssr72388	Chr7:45434452-45434478 (-)	867 bp
Tssr2249	Chr7:45434432-45434451 (-)	890 bp
Tssr72387	Chr7:45434267-45434308 (-)	1,044 bp
Tssr72386	Chr7:45422473-45422487 (-)	12,852 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14