Ruvbl2
Gene Detail

Symbol Name ID

Ruvbl2 RuvB-like protein 2 MGI:1342299

Synonyms

mp47, p47

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.30 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:45421852-45438096 bp, - strand From VEGA annotation of GRCm38   16245 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: conserved hypothetical protein YDR190c
Gene Tree: Ruvbl2

Human homologs

Human Homolog		RUVBL2, RuvB-like AAA ATPase 2
NCBI Gene ID		10856
neXtProt AC		NX_Q9Y230
Human Synonyms		ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B
Human Chr (Location)		19q13.3; chr19:48993481-49015926 (+)  GRCh38

Alleles and phenotypes

All alleles(15) : Chemically induced (ENU)(1) Gene trapped(11) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	ATP catabolic process, cellular response to DNA damage stimulus, ...
Component	cytoplasm, extracellular vesicular exosome, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (57)    Tissues (33)    Images (19)
Theiler Stages: 15, 17, 19, 23

Assay Type	Results
RNA in situ	57

cDNA source data(141)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(141) cDNA(141)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023863 (Evidence)
Ensembl Gene Model	ENSMUSG00000003868 (Evidence)
Entrez Gene	20174 (Evidence)
UniGene	34410
DFCI	TC1574957, TC1607918, TC1608107, TC1741912, TC1763442
NIA Mouse Gene Index	U028528
EC	3.6.4.12
Consensus CDS Project	CCDS21243.1
International Mouse Knockout Project Status	Ruvbl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023863	VEGA Gene Model | MGI Sequence Detail	16245	C57BL/6J
transcript	OTTMUST00000058292	VEGA | MGI Sequence Detail	2220	Not Applicable
polypeptide	OTTMUSP00000028218	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(58) RefSeq(6) UniProt(4)

Polymorphisms

SNPs within 2kb(102 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR004504	DNA repair protein RadA
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR027238	RuvB-like
InterPro	IPR010339	TIP49, C-terminal
Protein Ontology	PR:000014369	RuvB-like 2

References

(Earliest) J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
(Latest) J:185495 Arnold CN, et al., A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012 Jul 3;
All references(34)