Ruvbl2 MGI Mouse Gene Detail - MGI:1342299

Ruvbl2 Gene Detail

Symbol

Ruvbl2
Name

RuvB-like protein 2
Synonyms

mp47, p47

Feature Type

protein coding gene
IDs

MGI:1342299
NCBI Gene: 20174
Gene Overview

MyGene.info: RUVBL2

Sequence Map

Chr7:45421760-45438096 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

16337 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.30 cM, cytoband B2
Mapping Data

1 experiment

Human Ortholog

RUVBL2, RuvB like AAA ATPase 2

Vertebrate Orthologs

9

Human Ortholog

RUVBL2, RuvB like AAA ATPase 2
Orthology source: HomoloGene, HGNC
Synonyms

CGI-46, ECP51, ECP-51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B
Links

HGNC:10475

NCBI Gene ID: 10856

neXtProt AC: NX_Q9Y230
Chr Location

19q13.3; chr19:48993353-49015926 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4856
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RUVBL2
Protein SuperFamily

conserved hypothetical protein YDR190c
Gene Tree

Ruvbl2

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF

Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.

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All GO Annotations

56
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

57
Tissues

33
cDNA Data

141
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ruvbl2

ZFIN ruvbl2

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Ruvbl2 interacts with 25 markers (Mir27a, Mir27b, Mir128-1, ...) View All

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All Sequences

71
RefSeq

6
UniProt

3
CCDS

CCDS21243.1
UniGene

34410

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023863	VEGA Gene Model \| MGI Sequence Detail	16337	C57BL/6J	± kb
transcript	OTTMUST00000058292	VEGA \| MGI Sequence Detail	2312	Not Applicable
polypeptide	OTTMUSP00000028218	VEGA \| MGI Sequence Detail	463	Not Applicable

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SNPs within 2kb

102 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000014369 RuvB-like 2
EC

3.6.4.12
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR027238 RuvB-like

IPR010339 TIP49, C-terminal

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All nucleic 141

cDNA 141

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 6
Earliest

J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
Latest

J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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