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Ruvbl2
Gene Detail
 Symbol
Name
ID
Ruvbl2
RuvB-like protein 2
MGI:1342299
Synonyms mp47, p47
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.30 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:45421852-45438096 bp, - strand
From VEGA annotation of GRCm38

  16245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: conserved hypothetical protein YDR190c
Gene Tree: Ruvbl2

Human
homologs
Human Homolog RUVBL2, RuvB-like AAA ATPase 2
NCBI Gene ID 10856
neXtProt AC  NX_Q9Y230
Human Synonyms  ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B
Human Chr (Location)  19q13.3; chr19:48993481-49015926 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(11) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.
 
Interactions
Ruvbl2 interacts with 25 markers (Mir27a, Mir27b, Mir128-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process ATP catabolic process, cellular response to DNA damage stimulus, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (57)    Tissues (33)    Images (19)
Theiler Stages: 15, 17, 19, 23
Assay TypeResults
RNA in situ 57
cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) cDNA(141)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023863 (Evidence)
Ensembl Gene ModelENSMUSG00000003868 (Evidence)
Entrez Gene20174 (Evidence)
UniGene34410
DFCITC1574957, TC1607918, TC1608107, TC1741912, TC1763442
NIA Mouse Gene IndexU028528
EC3.6.4.12
Consensus CDS ProjectCCDS21243.1
International Mouse Knockout Project StatusRuvbl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023863 VEGA Gene Model | MGI Sequence Detail 16245 C57BL/6J ±  kb
transcript OTTMUST00000058292 VEGA | MGI Sequence Detail 2220 Not Applicable 
polypeptide OTTMUSP00000028218 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR004504 DNA repair protein RadA
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR027238 RuvB-like
InterPro IPR010339 TIP49, C-terminal
Protein Ontology PR:000014369 RuvB-like 2
References (Earliest) J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
(Latest) J:185495 Arnold CN, et al., A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012 Jul 3;
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory