Ruvbl2
Gene Detail

Symbol

Name
ID

Ruvbl2
RuvB-like protein 2
MGI:1342299

Synonyms

mp47, p47

Feature Type

protein coding gene

Genetic Map

Chromosome 7
29.30 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:45421852-45438096 bp, - strand From VEGA annotation of GRCm38   16245 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: conserved hypothetical protein YDR190c
Gene Tree: Ruvbl2

Human
homologs

Human Homolog		RUVBL2, RuvB-like AAA ATPase 2
NCBI Gene ID		10856
neXtProt AC		NX_Q9Y230
Human Synonyms		CGI-46, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B
Human Chr (Location)		19q13.3; chr19:48993481-49015926 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(11) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.

 

Interactions

Ruvbl2 interacts with 25 markers (Mir27a, Mir27b, Mir128-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (42 annotations)

Process	cellular response to DNA damage stimulus, cellular response to estradiol stimulus, ...
Component	cytoplasm, extracellular vesicular exosome, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (57)    Tissues (33)    Images (19)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	57

cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(141) cDNA(141)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000023863 (Evidence)
Ensembl Gene Model	ENSMUSG00000003868 (Evidence)
Entrez Gene	20174 (Evidence)
UniGene	34410
NIA Mouse Gene Index	U028528
EC	3.6.4.12
Consensus CDS Project	CCDS21243.1
International Mouse Knockout Project Status	Ruvbl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023863	VEGA Gene Model | MGI Sequence Detail	16245	C57BL/6J
transcript	OTTMUST00000058292	VEGA | MGI Sequence Detail	2220	Not Applicable
polypeptide	OTTMUSP00000028218	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(53) RefSeq(6) UniProt(4)

Polymorphisms

SNPs within 2kb(102 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR004504	DNA repair protein RadA
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR027238	RuvB-like
InterPro	IPR010339	TIP49, C-terminal
Protein Ontology	PR:000014369	RuvB-like 2

References

(Earliest) J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(34)