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Ruvbl2 Gene Detail
Summary
  • Symbol
    Ruvbl2
  • Name
    RuvB-like protein 2
  • Synonyms
    mp47, p47
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342299
    NCBI Gene: 20174
  • Gene Overview
    MyGene.info: RUVBL2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45421760-45438096 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16337 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.30 cM, cytoband B2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RUVBL2, RuvB like AAA ATPase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RUVBL2, RuvB like AAA ATPase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-46, ECP51, ECP-51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B
  • Links
    NCBI Gene ID: 10856
    neXtProt AC: NX_Q9Y230
    UniProt: Q9Y230

  • Chr Location
    19q13.33; chr19:48993448-49015995 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023863 VEGA Gene Model | MGI Sequence Detail 16337 C57BL/6J ±  kb
    transcript OTTMUST00000058292 VEGA | MGI Sequence Detail 2312 Not Applicable  
    polypeptide OTTMUSP00000028218 VEGA | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      102 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 141

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
    • Latest
      J:228312 Tarangelo A, et al., Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory