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Ruvbl2 Gene Detail
Summary
  • Symbol
    Ruvbl2
  • Name
    RuvB-like protein 2
  • Synonyms
    mp47, p47
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342299
    NCBI Gene: 20174
  • Gene Overview
    MyGene.info: RUVBL2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45421896-45435332 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.30 cM, cytoband B2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342299
protein coding gene Chr7:45421760-45438096 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032221
protein coding gene Chr7:45677846-45694167 (-)
A/J MGP_AJ_G0032200
protein coding gene Chr7:44808531-44824773 (-)
AKR/J MGP_AKRJ_G0032136
protein coding gene Chr7:46051422-46067666 (-)
BALB/cJ MGP_BALBcJ_G0032212
protein coding gene Chr7:44797504-44813782 (-)
C3H/HeJ MGP_C3HHeJ_G0031928
protein coding gene Chr7:46530665-46547979 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032704
protein coding gene Chr7:47948311-47964549 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029718
protein coding gene Chr7:47359324-47375197 (-)
CAST/EiJ MGP_CASTEiJ_G0031256
protein coding gene Chr7:37942435-37960423 (-)
CBA/J MGP_CBAJ_G0031892
protein coding gene Chr7:49529475-49545701 (-)
DBA/2J MGP_DBA2J_G0032050
protein coding gene Chr7:44470987-44487271 (-)
FVB/NJ MGP_FVBNJ_G0032001
protein coding gene Chr7:44256573-44272819 (-)
LP/J MGP_LPJ_G0032128
protein coding gene Chr7:46379127-46396862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032038
protein coding gene Chr7:48232023-48249477 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032720
protein coding gene Chr7:45264303-45280565 (-)
PWK/PhJ MGP_PWKPhJ_G0030979
protein coding gene Chr7:37845803-37862141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030816
protein coding gene Chr7:33272927-33289123 (-)
WSB/EiJ MGP_WSBEiJ_G0031373
protein coding gene Chr7:45758960-45775586 (-)



Homology
more
  • Human Ortholog
    RUVBL2, RuvB like AAA ATPase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RUVBL2, RuvB like AAA ATPase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-46, ECP51, ECP-51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B
  • Links
    NCBI Gene ID: 10856
    neXtProt AC: NX_Q9Y230
    UniProt: Q9Y230

  • Chr Location
    19q13.33; chr19:48993448-49015995 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20174 NCBI Gene Model | MGI Sequence Detail 13437 C57BL/6J ±  kb
    transcript NM_011304 RefSeq | MGI Sequence Detail 1675 C57BL/6  
    polypeptide Q9WTM5 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 142

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:55328 Gohshi T, et al., Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May;125(5):939-46
    • Latest
      J:228312 Tarangelo A, et al., Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory