Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Reln

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RELN
- Mouse genes Reln
- Rat genes Reln
- Zfish genes reln
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Reln

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070325	lipoprotein particle receptor binding	Reln	IPI	UniProtKB:P01130\|UniProtKB:Q924X6	Mouse	MGI:MGI:5306330\|PMID:10571240
Molecular Function	GO:0005515	protein binding	Reln	IPI	UniProtKB:P98155\|UniProtKB:Q14114	Mouse	MGI:MGI:5926406\|PMID:20223215
Molecular Function	GO:0005515	protein binding	Reln	IPI	UniProtKB:P98155\|UniProtKB:Q924X6	Mouse	MGI:MGI:5582185\|PMID:10571241
Molecular Function	GO:0005515	protein binding	Reln	IPI	UniProtKB:P98155\|UniProtKB:Q14114	Mouse	MGI:MGI:6093439\|PMID:17548821
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	Reln	IPI	UniProtKB:P98155	Mouse	MGI:MGI:5306330\|PMID:10571240
Cellular Component	GO:0030424	axon	Reln	IDA		Rat	PMID:16420448\|RGD:2317798
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Reln	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Reln	IDA		Mouse	PMID:15525772
Cellular Component	GO:0005737	cytoplasm	Reln	IDA		Mouse	PMID:19409883
Cellular Component	GO:0005737	cytoplasm	Reln	IDA		Rat	PMID:10077664\|RGD:2317955
Cellular Component	GO:0030425	dendrite	Reln	IDA		Mouse	PMID:15677725
Cellular Component	GO:0030425	dendrite	Reln	IDA		Rat	PMID:19515914\|RGD:2317767
Cellular Component	GO:0031012	extracellular matrix	Reln	IDA		Mouse	PMID:22665518
Cellular Component	GO:0005615	extracellular space	Reln	IDA		Mouse	MGI:MGI:3621707\|PMID:10939329
Cellular Component	GO:0005615	extracellular space	Reln	IDA		Mouse	PMID:12526740
Cellular Component	GO:0005615	extracellular space	Reln	IDA		Mouse	PMID:12724835
Cellular Component	GO:0005615	extracellular space	Reln	IDA		Rat	PMID:18449964\|RGD:2317777
Cellular Component	GO:0043005	neuron projection	Reln	IDA		Rat	PMID:14757522\|RGD:2317802
Cellular Component	GO:0043025	neuronal cell body	Reln	IDA		Rat	PMID:19515914\|RGD:2317767
Cellular Component	GO:0043204	perikaryon	Reln	IDA		Rat	PMID:11923015\|RGD:2317889
Cellular Component	GO:0110157	reelin complex	RELN	IDA		Human	PMID:21844191
Biological Process	GO:0008306	associative learning	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0008306	associative learning	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0007411	axon guidance	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:16324103
Biological Process	GO:0007420	brain development	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:12223565
Biological Process	GO:0007420	brain development	Reln	IMP		Rat	PMID:2709802\|RGD:1358345
Biological Process	GO:0016477	cell migration	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:17694053
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:12925587
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Reln	IEP		Rat	PMID:11983443\|RGD:2317888
Biological Process	GO:0007417	central nervous system development	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:11900467
Biological Process	GO:0021692	cerebellar Purkinje cell layer morphogenesis	reln	IMP	ZFIN:ZDB-GENO-200513-4	Zfish	PMID:31323192
Biological Process	GO:0021987	cerebral cortex development	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:21491433
Biological Process	GO:0021987	cerebral cortex development	Reln	IEP		Rat	PMID:10436054\|RGD:634730
Biological Process	GO:0021800	cerebral cortex tangential migration	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:16901480
Biological Process	GO:0016358	dendrite development	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:14715136
Biological Process	GO:0016358	dendrite development	Reln	IGI	MGI:MGI:108554	Mouse	PMID:14715136
Biological Process	GO:0021542	dentate gyrus development	Reln	IMP		Rat	PMID:15459104\|RGD:2317799
Biological Process	GO:0030900	forebrain development	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:17694053
Biological Process	GO:0010001	glial cell differentiation	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:12925587
Biological Process	GO:0021766	hippocampus development	Reln	IDA		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0021854	hypothalamus development	Reln	IEP		Rat	PMID:10436054\|RGD:634730
Biological Process	GO:1904936	interneuron migration	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:14980731
Biological Process	GO:0097477	lateral motor column neuron migration	Reln	IMP		Mouse	MGI:MGI:4849611\|PMID:20711475
Biological Process	GO:0021819	layer formation in cerebral cortex	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:20847152
Biological Process	GO:0007612	learning	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0007626	locomotory behavior	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:24539699
Biological Process	GO:0007626	locomotory behavior	Reln	IMP		Rat	PMID:12670697\|RGD:727518
Biological Process	GO:0007616	long-term memory	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0007616	long-term memory	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0060291	long-term synaptic potentiation	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0007613	memory	Reln	IEP		Rat	PMID:17359920\|RGD:2317782
Biological Process	GO:0007494	midgut development	Reln	IEP		Rat	PMID:19946030\|RGD:2317766
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Reln	IMP		Mouse	MGI:MGI:3821675\|PMID:18778775
Biological Process	GO:0097475	motor neuron migration	Reln	IMP	MGI:MGI:1856416	Mouse	PMID:15703280
Biological Process	GO:0001764	neuron migration	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:12724835
Biological Process	GO:0001764	neuron migration	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:12223565
Biological Process	GO:0001764	neuron migration	Reln	IGI	MGI:MGI:101764	Mouse	PMID:11226314
Biological Process	GO:0001764	neuron migration	Reln	IMP		Rat	PMID:12670697\|RGD:727518
Biological Process	GO:0097114	NMDA glutamate receptor clustering	Reln	IMP		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0021769	orbitofrontal cortex development	Reln	IEP		Rat	PMID:20035841\|RGD:2317761
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Reln	IDA		Mouse	PMID:12526740
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	Reln	IMP		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	Reln	IDA		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Reln	IMP		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Reln	IMP		Mouse	MGI:MGI:4442532\|PMID:20357114
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Reln	IMP		Mouse	MGI:MGI:5619457\|PMID:21814183
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Reln	IMP		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Reln	IDA		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:1902078	positive regulation of lateral motor column neuron migration	Reln	IMP		Mouse	MGI:MGI:4849611\|PMID:20711475
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0010976	positive regulation of neuron projection development	Reln	IMP		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Reln	IDA		Mouse	MGI:MGI:5306330\|PMID:10571240
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reln	IDA		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0045860	positive regulation of protein kinase activity	Reln	IGI	MGI:MGI:1340044	Mouse	PMID:12526740
Biological Process	GO:0045860	positive regulation of protein kinase activity	Reln	IDA		Mouse	PMID:12526740
Biological Process	GO:0045860	positive regulation of protein kinase activity	Reln	IGI	MGI:MGI:108554	Mouse	PMID:12526740
Biological Process	GO:0045860	positive regulation of protein kinase activity	Reln	IGI	MGI:MGI:98935	Mouse	PMID:12526740
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Reln	IDA		Mouse	MGI:MGI:6810281\|PMID:21844191
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Reln	IMP		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	Reln	IDA		Mouse	PMID:15062102
Biological Process	GO:0090129	positive regulation of synapse maturation	Reln	IMP		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0090129	positive regulation of synapse maturation	Reln	IDA		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Reln	IMP		Mouse	MGI:MGI:5619457\|PMID:21814183
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Reln	IMP		Mouse	MGI:MGI:4442532\|PMID:20357114
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Reln	IDA		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Reln	IMP		Mouse	MGI:MGI:3765383\|PMID:17229826
Biological Process	GO:0032008	positive regulation of TOR signaling	Reln	IDA		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	Reln	IMP		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0035418	protein localization to synapse	Reln	IMP		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0097120	receptor localization to synapse	Reln	IMP		Mouse	MGI:MGI:5286805\|PMID:21664258
Biological Process	GO:0038026	reelin-mediated signaling pathway	Reln	IDA		Mouse	MGI:MGI:5306330\|PMID:10571240
Biological Process	GO:0038026	reelin-mediated signaling pathway	Reln	IDA		Mouse	MGI:MGI:5426130\|PMID:21852430
Biological Process	GO:0050795	regulation of behavior	Reln	IMP		Mouse	MGI:MGI:4442532\|PMID:20357114
Biological Process	GO:0010468	regulation of gene expression	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:15255972
Biological Process	GO:2000310	regulation of NMDA receptor activity	Reln	IMP		Mouse	MGI:MGI:5619457\|PMID:21814183
Biological Process	GO:2000310	regulation of NMDA receptor activity	Reln	IMP		Mouse	MGI:MGI:4442532\|PMID:20357114
Biological Process	GO:0043200	response to amino acid	Reln	IEP		Rat	PMID:16484373\|RGD:2317797
Biological Process	GO:0048678	response to axon injury	Reln	IEP		Rat	PMID:18625290\|RGD:2317775
Biological Process	GO:0051412	response to corticosterone	Reln	IEP		Rat	PMID:19477232\|RGD:2317770
Biological Process	GO:0051602	response to electrical stimulus	Reln	IEP		Rat	PMID:19499587\|RGD:2317769
Biological Process	GO:0045471	response to ethanol	Reln	IEP		Rat	PMID:15166098\|RGD:2317800
Biological Process	GO:0070542	response to fatty acid	Reln	IEP		Rat	PMID:19447164\|RGD:2317771
Biological Process	GO:0009725	response to hormone	Reln	IEP		Rat	PMID:20018181\|RGD:2317764
Biological Process	GO:0017085	response to insecticide	Reln	IEP		Rat	PMID:16675515\|RGD:2317793
Biological Process	GO:0010226	response to lithium ion	Reln	IEP		Rat	PMID:19359144\|RGD:2317787
Biological Process	GO:0009612	response to mechanical stimulus	Reln	IEP		Rat	PMID:19357777\|RGD:2317773
Biological Process	GO:0014070	response to organic cyclic compound	Reln	IEP		Rat	PMID:17359920\|RGD:2317782
Biological Process	GO:0048265	response to pain	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:16580148
Biological Process	GO:0032570	response to progesterone	Reln	IEP		Rat	PMID:18625290\|RGD:2317775
Biological Process	GO:0009636	response to toxic substance	Reln	IEP		Rat	PMID:16733048\|RGD:2317792
Biological Process	GO:0009410	response to xenobiotic stimulus	Reln	IEP		Rat	PMID:19359144\|RGD:2317787
Biological Process	GO:0035176	social behavior	Reln	IEP		Rat	PMID:20035841\|RGD:2317761
Biological Process	GO:0021511	spinal cord patterning	Reln	IMP	MGI:MGI:1856398	Mouse	PMID:16580148
Biological Process	GO:0021511	spinal cord patterning	Reln	IEP		Rat	PMID:14648677\|RGD:2317803
Biological Process	GO:0042403	thyroid hormone metabolic process	Reln	IMP	MGI:MGI:1856398	Mouse	MGI:MGI:85368
Biological Process	GO:0021517	ventral spinal cord development	Reln	IEP		Mouse	MGI:MGI:4849611\|PMID:20711475

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.