Reln
Gene Detail

Symbol Name ID

Reln reelin MGI:103022

Feature Type

protein coding gene

Genetic Map

Chromosome 5

9.98 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

Chr5:21884454-22344702 bp, - strand From VEGA annotation of GRCm38   460249 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Reln

Human homologs

Human Homolog		RELN, reelin
NCBI Gene ID		5649
neXtProt AC		NX_P78509
Human Synonyms		LIS2, PRO1598, RL
Human Chr (Location)		7q22; chr7:103112231-103629963 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RELN

Alleles and phenotypes

All alleles(16) : Targeted(4) Transgenic(1) Spontaneous(7) Chemically induced(4)
 

Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (76 annotations)

Process	associative learning, axon guidance, ...
Component	axon, cytoplasm, ...
Function	hydrolase activity, lipoprotein particle receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (282 records)
Data Summary: Results (267)    Tissues (201)    Images (78)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	11
RNA in situ	237
Northern blot	7
RT-PCR	12

cDNA source data(114)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(160) Genomic(24) cDNA(120) Primer pair(11) Other(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030584 (Evidence)
Ensembl Gene Model	ENSMUSG00000042453 (Evidence)
Entrez Gene	19699 (Evidence)
UniGene	425236
DFCI	TC1578722, TC1595889, TC1596615, TC1672277
DoTS	DT.486700, DT.55165850, DT.91310973, DT.91311417, DT.91356456, DT.91370906, DT.91395221
NIA Mouse Gene Index	U025970
EC	3.4.21.-
PDB	2DDU, 3A7Q, 2E26
Consensus CDS Project	CCDS39023.1
International Mouse Knockout Project Status	Reln

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030584	VEGA Gene Model | MGI Sequence Detail	460249	C57BL/6J
transcript	OTTMUST00000075740	VEGA | MGI Sequence Detail	11699	Not Applicable
polypeptide	OTTMUSP00000039767	VEGA | MGI Sequence Detail	3461	Not Applicable

All sequences(72) RefSeq(2) UniProt(7)

Polymorphisms

All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs(3545 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR011040	Neuraminidase
InterPro	IPR002861	Reeler domain
Protein Ontology	PR:000013879	reelin

References

(Earliest) J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50:192-201
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(563)

Other accession IDs

MGD-MRK-13895, MGD-MRK-23859