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Reln
Gene Detail
Symbol

Name
ID
Reln
reelin
MGI:103022
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.98 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr5:21884454-22344702 bp, - strand
From VEGA annotation of GRCm38

  460249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RELN
Gene Tree: Reln

Human
homologs
RELN, reelin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5649
neXtProt AC: NX_P78509

Human Synonyms: LIS2, PRO1598, RL

Human Chr (Location): 7q22; chr7:103471784-103989516 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RELN

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(4) Chemically induced (other)(2) Spontaneous(7) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.
 
Phenotype Images(2)
Interactions
Reln interacts with 318 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process associative learning, axon guidance, ...
Component axon, cytoplasm, ...
Function hydrolase activity, lipoprotein particle receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (323 records)
Data Summary: Results (423)    Tissues (291)    Images (127)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 362
Northern blot 7
Western blot 12
RT-PCR 12
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase reln ; ZFIN reln    NEW 
Molecular
reagents
All nucleic(161) Genomic(24) cDNA(121) Primer pair(11) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030584 (Evidence)
Ensembl Gene Model ENSMUSG00000042453 (Evidence)
Entrez Gene 19699 (Evidence)
UniGene 425236
DFCI TC1578722, TC1595889, TC1672277, TC1596615
DoTS DT.55165850, DT.486700, DT.91370906, DT.91356456, DT.91311417, DT.91310973, DT.91395221
NIA Mouse Gene Index U025970
EC 3.4.21.-
PDB 3A7Q, 2DDU, 2E26
Consensus CDS Project CCDS39023.1
International Mouse Phenotyping Consortium Status Reln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030584 VEGA Gene Model | MGI Sequence Detail 460249 C57BL/6J ±  kb
transcript OTTMUST00000075740 VEGA | MGI Sequence Detail 11699 Not Applicable 
polypeptide OTTMUSP00000039767 VEGA | MGI Sequence Detail 3461 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(8) UniProt(7)
Polymorphisms
All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(4036 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4038)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002861 Reeler domain
InterPro IPR011040 Sialidases
Protein Ontology PR:000013879 reelin
References
(Earliest) J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50:192-201
(Latest) J:219839 Hirota Y, et al., Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015 Feb 15;523(3):463-78
All references(618)
Other
accession IDs
MGD-MRK-13895, MGD-MRK-23859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory