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Reln Gene Detail
Summary
  • Symbol
    Reln
  • Name
    reelin
  • Feature Type
    protein coding gene
  • IDs
    MGI:103022
    NCBI Gene: 19699
  • Gene Overview
    MyGene.info: RELN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21884454-22344702 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.98 cM, cytoband A3-B1
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3933 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103022
protein coding gene Chr5:21884454-22344705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029326
protein coding gene Chr5:19470485-19937042 (-)
A/J MGP_AJ_G0029291
protein coding gene Chr5:18827726-19294099 (-)
AKR/J MGP_AKRJ_G0029242
protein coding gene Chr5:19550896-20023364 (-)
BALB/cJ MGP_BALBcJ_G0029303
protein coding gene Chr5:19264102-19722346 (-)
C3H/HeJ MGP_C3HHeJ_G0029022
protein coding gene Chr5:19623634-20097891 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029756
protein coding gene Chr5:20879604-21365242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026995
protein coding gene Chr5:16884756-17323564 (-)
CAST/EiJ MGP_CASTEiJ_G0028434
protein coding gene Chr5:18959829-19433537 (-)
CBA/J MGP_CBAJ_G0028989
protein coding gene Chr5:21123931-21632446 (-)
DBA/2J MGP_DBA2J_G0029141
protein coding gene Chr5:19113072-19573000 (-)
FVB/NJ MGP_FVBNJ_G0029099
protein coding gene Chr5:18516531-18972019 (-)
LP/J MGP_LPJ_G0029225
protein coding gene Chr5:19878398-20337809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029127
protein coding gene Chr5:22383401-22870716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029789
protein coding gene Chr5:19204126-19649447 (-)
PWK/PhJ MGP_PWKPhJ_G0028157
protein coding gene Chr5:18170825-18622228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027990
protein coding gene Chr5:18575683-19054603 (-)
WSB/EiJ MGP_WSBEiJ_G0028514
protein coding gene Chr5:19271342-19732417 (-)



Homology
more
  • Human Ortholog
    RELN, reelin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RELN, reelin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETL7, LIS2, PRO1598, RL
  • Links
    NCBI Gene ID: 5649
    neXtProt AC: NX_P78509
    UniProt: P78509

  • Chr Location
    7q22.1; chr7:103471784-103989516 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3699
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RELN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Reln mouse models; 3 with human RELN associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 14 alleles in 21 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    297 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042453 Ensembl Gene Model | MGI Sequence Detail 460249 C57BL/6J ±  kb
    transcript ENSMUST00000161356 Ensembl | MGI Sequence Detail 11699 Not Applicable  
    polypeptide ENSMUSP00000124052 Ensembl | MGI Sequence Detail 3461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 164
      Genomic 24
      cDNA 126
      Primer pair 13
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13895, MGD-MRK-23859
    References
    more
    • Summaries
      All 721
      Developmental Gene Expression 369
      Diseases 3
      Gene Ontology 37
      Phenotypes 297
    • Earliest
      J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50:192-201
    • Latest
      J:264763 Lanjakornsiripan D, et al., Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers. Nat Commun. 2018 Apr 24;9(1):1623

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory