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Reln
Gene Detail
 Symbol
Name
ID
Reln
reelin
MGI:103022
Feature Type protein coding gene
Genetic Map
Chromosome 5
9.98 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr5:21884454-22344702 bp, - strand
From VEGA annotation of GRCm38

  460249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Reln

Human
homologs
Human Homolog RELN, reelin
NCBI Gene ID 5649
neXtProt AC  NX_P78509
Human Synonyms  LIS2, PRO1598, RL
Human Chr (Location)  7q22; chr7:103471784-103989516 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RELN
Alleles
and
phenotypes
All alleles(17) : Targeted(4) Transgenic(1) Spontaneous(7) Chemically induced(5)
 
Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (78 annotations)
Process associative learning, axon guidance, ...
Component axon, cytoplasm, ...
Function hydrolase activity, lipoprotein particle receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (298 records)
Data Summary: Results (273)    Tissues (204)    Images (84)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 243
Northern blot 7
RT-PCR 12
cDNA source data(115)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(161) Genomic(24) cDNA(121) Primer pair(11) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030584 (Evidence)
Ensembl Gene ModelENSMUSG00000042453 (Evidence)
Entrez Gene19699 (Evidence)
UniGene425236
DFCITC1578722, TC1595889, TC1596615, TC1672277
DoTSDT.486700, DT.55165850, DT.91310973, DT.91311417, DT.91356456, DT.91370906, DT.91395221
NIA Mouse Gene IndexU025970
EC3.4.21.-
PDB2DDU, 3A7Q, 2E26
Consensus CDS ProjectCCDS39023.1
International Mouse Knockout Project StatusReln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030584 VEGA Gene Model | MGI Sequence Detail 460249 C57BL/6J ±  kb
transcript OTTMUST00000075740 VEGA | MGI Sequence Detail 11699 Not Applicable 
polypeptide OTTMUSP00000039767 VEGA | MGI Sequence Detail 3461 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(8) UniProt(7)
Polymorphisms All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(4036 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4038)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002861 Reeler domain
InterPro IPR011040 Sialidases
Protein Ontology PR:000013879 reelin
References (Earliest) J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50:192-201
(Latest) J:206162 Chu HC, et al., Erythroid differentiation is augmented in Reelin-deficient K562 cells and homozygous reeler mice. FEBS Lett. 2014 Jan 3;588(1):58-64
All references(588)
Other
accession IDs
MGD-MRK-13895, MGD-MRK-23859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory