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Reln Gene Detail
Summary
  • Symbol
    Reln
  • Name
    reelin
  • Feature Type
    protein coding gene
  • IDs
    MGI:103022
    NCBI Gene: 19699
  • Gene Overview
    MyGene.info: RELN
Location & Maps
more
  • Sequence Map
    Chr5:21884454-22344702 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      460249 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.98 cM, cytoband A3-B1
  • Mapping Data
    29 experiments
Homology
more
  • Human Ortholog
    RELN, reelin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RELN, reelin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ETL7, LIS2, PRO1598, RL
  • Links
    NCBI Gene ID: 5649
    neXtProt AC: NX_P78509

  • Chr Location
    7q22; chr7:103471784-103989516 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3699
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RELN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Reln mouse models; 3 with human RELN associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 2 models
       Epilepsy, Familial Temporal Lobe, 1; ETL1   OMIM: 600512
Epilepsy, Familial Temporal Lobe, 7; ETL7   OMIM: 616436
Lissencephaly 2; LIS2   OMIM: 257320
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 14 alleles in 21 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    273 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    4
  • Radiation induced
    1
  • Spontaneous
    8
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    4 involving Reln
  • Incidental Mutations
Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030584 VEGA Gene Model | MGI Sequence Detail 460249 C57BL/6J ±  kb
transcript OTTMUST00000075740 VEGA | MGI Sequence Detail 11699 Not Applicable  
polypeptide OTTMUSP00000039767 VEGA | MGI Sequence Detail 3461 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3933 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    Genomic 24
    cDNA 125
    Primer pair 13
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13895, MGD-MRK-23859
References
more
  • Summaries
    All 639
    Developmental Gene Expression 336
    Diseases 3
    Gene Ontology 34
    Phenotypes 273
  • Earliest
    J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50:192-201
  • Latest
    J:230724 Cionni M, et al., Novel genetic tools facilitate the study of cortical neuron migration. Mamm Genome. 2016 Feb;27(1-2):8-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory