Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rap1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RAP1A
- Mouse genes Rap1a
- Rat genes Rap1a
- Zfish genes rap1aa,rap1ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rap1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	Rap1a	IDA		Rat	PMID:20339002\|RGD:10003134
Molecular Function	GO:0003924	GTPase activity	Rap1a	IDA		Mouse	PMID:12473665
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rap1a	IMP		Rat	PMID:17724123\|RGD:8554481
Molecular Function	GO:0004708	MAP kinase kinase activity	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2,ZFIN:ZDB-MRPHLNO-151208-5	Zfish	PMID:26280580
Molecular Function	GO:0004708	MAP kinase kinase activity	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q9Y4G8	Human	PMID:10608844
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q9P212	Human	PMID:11022048
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q9Y4G8	Human	PMID:11359771
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q5EBH1	Human	PMID:12845325
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q8WWW0-2	Human	PMID:12845325
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q8WWW0-2	Human	PMID:15569673
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:Q5EBH1	Human	PMID:16698549
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:O00522	Human	PMID:17916086
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:P04049	Human	PMID:7791872
Molecular Function	GO:0005515	protein binding	RAP1A	IPI	UniProtKB:P04049	Human	PMID:8756332
Molecular Function	GO:0005515	protein binding	Rap1a	IPI	UniProtKB:Q9D9D3	Mouse	MGI:MGI:6827196\|PMID:30360518
Molecular Function	GO:0005515	protein binding	Rap1a	IPI	PR:P63321	Mouse	PMID:14712229
Molecular Function	GO:0005515	protein binding	Rap1a	IPI	PR:Q8R5A3	Mouse	PMID:17403904
Molecular Function	GO:0005515	protein binding	Rap1a	IPI	PR:Q5EBH1	Mouse	PMID:18596699
Molecular Function	GO:0005515	protein binding	Rap1a	IPI	RGD:1351009	Rat	PMID:16436672\|RGD:10003147
Molecular Function	GO:0044877	protein-containing complex binding	RAP1A	IDA		Human	PMID:23209302
Molecular Function	GO:0031267	small GTPase binding	Rap1a	IPI	RefSeq:NP_997129	Mouse	PMID:15894621
Cellular Component	GO:0030054	cell junction	Rap1a	IDA		Mouse	MGI:MGI:4359570\|PMID:19635461
Cellular Component	GO:0005737	cytoplasm	RAP1A	IDA		Human	PMID:11359771
Cellular Component	GO:0005737	cytoplasm	RAP1A	IDA		Human	PMID:23209302
Cellular Component	GO:0005737	cytoplasm	Rap1a	IDA		Mouse	PMID:22732430
Cellular Component	GO:0005737	cytoplasm	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Cellular Component	GO:0005769	early endosome	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Cellular Component	GO:0005769	early endosome	Rap1a	IDA		Rat	PMID:17822405\|RGD:10040965
Cellular Component	GO:0070062	extracellular exosome	RAP1A	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	RAP1A	IDA		Human	PMID:12202034
Cellular Component	GO:0098978	glutamatergic synapse	RAP1A	IMP		Human	PMID:12202034
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	Rap1a	IDA		Mouse	PMID:15894621
Cellular Component	GO:0005770	late endosome	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Cellular Component	GO:0043209	myelin sheath	Rap1a	HDA		Mouse	MGI:MGI:3834050\|PMID:17634366
Cellular Component	GO:0043005	neuron projection	Rap1a	IDA		Mouse	PMID:22732430
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RAP1A	IDA		Human	PMID:11359771
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rap1a	IDA		Rat	PMID:17822405\|RGD:10040965
Cellular Component	GO:0045335	phagocytic vesicle	Rap1a	IDA		Rat	PMID:18832707\|RGD:9835043
Cellular Component	GO:0005886	plasma membrane	Rap1a	IDA		Mouse	PMID:17403904
Cellular Component	GO:0097225	sperm midpiece	Rap1a	IDA		Mouse	MGI:MGI:6827196\|PMID:30360518
Biological Process	GO:0060536	cartilage morphogenesis	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0071320	cellular response to cAMP	RAP1A	IDA		Human	PMID:21840392
Biological Process	GO:0071320	cellular response to cAMP	Rap1a	IEP		Rat	PMID:20339002\|RGD:10003134
Biological Process	GO:0071333	cellular response to glucose stimulus	Rap1a	IEP		Rat	PMID:12196513\|RGD:10041023
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Rap1a	IEP		Rat	PMID:17822405\|RGD:10040965
Biological Process	GO:0071407	cellular response to organic cyclic compound	Rap1a	IDA		Rat	PMID:10908723\|RGD:10003157
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Rap1a	IDA		Rat	PMID:10908723\|RGD:10003157
Biological Process	GO:0003428	chondrocyte intercalation involved in growth plate cartilage morphogenesis	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2,ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1aa	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:26280580
Biological Process	GO:0060027	convergent extension involved in gastrulation	rap1ab	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:30018450
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	rap1ab	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:30018450
Biological Process	GO:0061028	establishment of endothelial barrier	RAP1A	IMP		Human	PMID:21840392
Biological Process	GO:0007507	heart development	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23226434
Biological Process	GO:0097421	liver regeneration	Rap1a	IEP		Rat	PMID:9015365\|RGD:10003155
Biological Process	GO:0000165	MAPK cascade	rap1aa	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-151208-5,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580\|ZFIN:ZDB-PUB-150819-11
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Rap1a	IMP		Rat	PMID:22012077\|RGD:9850086
Biological Process	GO:2000301	negative regulation of synaptic vesicle exocytosis	Rap1a	IGI	MGI:MGI:894315	Mouse	PMID:23616533
Biological Process	GO:0038180	nerve growth factor signaling pathway	Rap1a	IDA		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rap1a	IGI	MGI:MGI:894315	Mouse	PMID:23616533
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rap1a	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Rap1a	IMP		Rat	PMID:18832707\|RGD:9835043
Biological Process	GO:0046326	positive regulation of glucose import	Rap1a	IMP		Rat	PMID:17450172\|RGD:10040970
Biological Process	GO:0043547	positive regulation of GTPase activity	Rap1a	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0010976	positive regulation of neuron projection development	Rap1a	IDA		Mouse	PMID:22732430
Biological Process	GO:0010976	positive regulation of neuron projection development	Rap1a	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0010976	positive regulation of neuron projection development	Rap1a	IMP		Rat	PMID:20190816\|RGD:9835044
Biological Process	GO:0045860	positive regulation of protein kinase activity	Rap1a	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:2001214	positive regulation of vasculogenesis	Rap1a	IMP		Mouse	MGI:MGI:4359570\|PMID:19635461
Biological Process	GO:0072659	protein localization to plasma membrane	RAP1A	IDA		Human	PMID:17916086
Biological Process	GO:0032486	Rap protein signal transduction	RAP1A	IMP		Human	PMID:21840392
Biological Process	GO:1901888	regulation of cell junction assembly	RAP1A	IMP		Human	PMID:21840392
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	RAP1A	IDA		Human	PMID:12202034
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	RAP1A	IMP		Human	PMID:12202034
Biological Process	GO:0097327	response to antineoplastic agent	Rap1a	IDA		Rat	PMID:17822405\|RGD:10040965
Biological Process	GO:0009743	response to carbohydrate	Rap1a	IEP		Rat	PMID:9149109\|RGD:633760
Biological Process	GO:0007264	small GTPase mediated signal transduction	Rap1a	IDA		Mouse	PMID:12473665
Biological Process	GO:0016079	synaptic vesicle exocytosis	Rap1a	IGI	MGI:MGI:894315	Mouse	PMID:23616533

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.