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Rap1a
Gene Detail
 Symbol
Name
ID
Rap1a
RAS-related protein-1a
MGI:97852
Synonyms Krev-1, Rap1
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:105728282-105750328 bp, - strand
From NCBI annotation of GRCm38

  22047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Rap1a

Human
homologs
Human Homolog RAP1A, RAP1A, member of RAS oncogene family
NCBI Gene ID 5906
neXtProt AC  NX_P62834
Human Synonyms  C21KG, G-22K, KREV1, KREV-1, RAP1, SMGP21
Human Chr (Location)  1p13.3; chr1:111619783-111713479 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit impaired leukocyte migration and decreased angiogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cellular response to cAMP, cellular response to nerve growth factor stimulus, ...
Component cell junction, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (13)    Tissues (11)   
Theiler Stages: 1, 3, 4, 20, 28
Assay TypeResults
In situ reporter (knock in) 1
Western blot 4
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000068798 (Evidence)
Entrez Gene109905 (Evidence)
DFCITC1575644, TC1611295, TC1645535
DoTSDT.87044389, DT.97406476
Consensus CDS ProjectCCDS17711.1
International Mouse Knockout Project StatusRap1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 109905 NCBI Gene Model | MGI Sequence Detail 22047 C57BL/6J ±  kb
transcript NM_145541 RefSeq | MGI Sequence Detail 2474 C57BL/6 
polypeptide P62835 UniProt | EBI | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(5) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013719 ras-related protein Rap-1A
Graphical View of Protein Domain Structure
References (Earliest) J:9524 Kitayama H, et al., A ras-related gene with transformation suppressor activity. Cell. 1989 Jan 13;56(1):77-84
(Latest) J:209591 Potla U, et al., Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr 1;124(4):1757-69
All references(65)
Other
accession IDs
MGD-MRK-11607, MGD-MRK-13761, MGI:2139815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory