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Rap1a
Gene Detail
Symbol

Name
ID
Rap1a
RAS-related protein-1a
MGI:97852
Synonyms
Krev-1, Rap1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:105727267-105801330 bp, - strand
From Ensembl annotation of GRCm38

  74064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: RAP1A
Protein SuperFamily: ras protein
Gene Tree: Rap1a

Human
homologs
RAP1A, RAP1A, member of RAS oncogene family
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5906
neXtProt AC: NX_P62834

Human Synonyms: C21KG, G-22K, KREV1, KREV-1, RAP1, SMGP21

Human Chr (Location): 1p13.3; chr1:111619783-111716695 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit impaired leukocyte migration and decreased angiogenesis.
 
Interactions
Rap1a interacts with 303 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cellular response to cAMP, cellular response to drug, ...
Component cell junction, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (10)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 1
Western blot 4
RT-PCR 5
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rap1a ; ZFIN rap1aa, rap1ab    NEW 
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000068798 (Evidence)
Entrez Gene 109905 (Evidence)
DFCI TC1575644, TC1611295, TC1645535
DoTS DT.87044389, DT.97406476
NIA Mouse Gene Index U024473, U041409, U059708
Consensus CDS Project CCDS17711.1
International Mouse Phenotyping Consortium Status Rap1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068798 Ensembl Gene Model | MGI Sequence Detail 74064 C57BL/6J ±  kb
transcript ENSMUST00000090678 Ensembl | MGI Sequence Detail 2401 Not Applicable 
polypeptide ENSMUSP00000088174 Ensembl | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013719 ras-related protein Rap-1A
References
(Earliest) J:9524 Kitayama H, et al., A ras-related gene with transformation suppressor activity. Cell. 1989 Jan 13;56(1):77-84
(Latest) J:209591 Potla U, et al., Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr 1;124(4):1757-69
All references(71)
Other
accession IDs
MGD-MRK-11607, MGD-MRK-13761, MGI:2139815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory