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Rap1a Gene Detail
Summary
  • Symbol
    Rap1a
  • Name
    RAS-related protein 1a
  • Synonyms
    Krev-1, Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97852
    NCBI Gene: 109905
  • Gene Overview
    MyGene.info: RAP1A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105727267-105801336 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97852
protein coding gene Chr3:105727260-105801381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027720
protein coding gene Chr3:107102582-107184108 (-)
A/J MGP_AJ_G0027680
protein coding gene Chr3:103676738-103750113 (-)
AKR/J MGP_AKRJ_G0027645
protein coding gene Chr3:106249817-106332098 (-)
BALB/cJ MGP_BALBcJ_G0027692
protein coding gene Chr3:103459698-103536918 (-)
C3H/HeJ MGP_C3HHeJ_G0027422
protein coding gene Chr3:106588800-106668023 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028136
protein coding gene Chr3:111103566-111188766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025476
protein coding gene Chr3:99755057-99832457 (-)
CAST/EiJ MGP_CASTEiJ_G0026878
protein coding gene Chr3:105742577-105822274 (-)
CBA/J MGP_CBAJ_G0027397
protein coding gene Chr3:114844238-114927090 (-)
DBA/2J MGP_DBA2J_G0027539
protein coding gene Chr3:102916519-102994264 (-)
FVB/NJ MGP_FVBNJ_G0027507
protein coding gene Chr3:100850479-100916540 (-)
LP/J MGP_LPJ_G0027646
protein coding gene Chr3:108503528-108583677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027537
protein coding gene Chr3:120959883-121053156 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028191
protein coding gene Chr3:105803185-105882949 (-)
PWK/PhJ MGP_PWKPhJ_G0026604
protein coding gene Chr3:102696800-102775666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026425
protein coding gene Chr3:103829534-103908738 (-)
WSB/EiJ MGP_WSBEiJ_G0026958
protein coding gene Chr3:106359373-106438283 (-)



Homology
more
  • Human Ortholog
    RAP1A, RAP1A, member of RAS oncogene family
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RAP1A, RAP1A, member of RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21KG, G-22K, KREV1, KREV-1, RAP1, SMGP21
  • Links
    NCBI Gene ID: 5906
    neXtProt AC: NX_P62834
    UniProt: P62834

  • Chr Location
    1p13.2; chr1:111542223-111716695 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Rap1a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a null allele exhibit impaired leukocyte migration and decreased angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068798 Ensembl Gene Model | MGI Sequence Detail 74070 C57BL/6J ±  kb
transcript ENSMUST00000090678 Ensembl | MGI Sequence Detail 2407 Not Applicable  
polypeptide ENSMUSP00000088174 Ensembl | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 12
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11607, MGD-MRK-13761, MGI:2139815
References
more
  • Summaries
    All 102
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 14
    Phenotypes 31
  • Earliest
    J:9524 Kitayama H, et al., A ras-related gene with transformation suppressor activity. Cell. 1989 Jan 13;56(1):77-84
  • Latest
    J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory