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Term Detail
GO term:guanyl-nucleotide exchange factor activity
Synonym: GDP-dissociation stimulator activity
Synonym: GDS
Synonym: GEF
Synonym: GNRP
Synonym: guanyl-nucleotide release factor activity
Synonym: guanyl-nucleotide releasing factor
GO id:GO:0005085
Alternate id: GO:0019839, GO:0008433, GO:0016219
Definition:Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
CommentsNote that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-amolecular function regulator
                        is-achannel regulator activity +
                        is-adecoy death receptor activity
                        is-aenzyme regulator activity +
                        is-aguanyl-nucleotide exchange factor activity [GO:0005085] (188 genes, 353 annotations)
                                is-aARF guanyl-nucleotide exchange factor activity
                                is-acyclic nucleotide-dependent guanyl-nucleotide exchange factor activity
                                is-aRas guanyl-nucleotide exchange factor activity +
                                is-aSar guanyl-nucleotide exchange factor activity
                        is-areceptor regulator activity +

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory