Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPN2
  • Mouse genes Ptpn2
  • Rat genes Ptpn2
  • Zfish genes ptpn2a,ptpn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	PTPN2	IPI	UniProtKB:P56199	Human	PMID:15592458
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Ptpn2	IDA		Rat	PMID:8534367|RGD:729799
Molecular Function	GO:0005515	protein binding	PTPN2	IPI	UniProtKB:P10912	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	PTPN2	IPI	UniProtKB:Q12933	Human	PMID:15696169
Molecular Function	GO:0005515	protein binding	PTPN2	IPI	UniProtKB:Q2GHU2	Human	PMID:19273555
Molecular Function	GO:0005515	protein binding	PTPN2	IPI	UniProtKB:P06239	Human	PMID:22080863
Molecular Function	GO:0005515	protein binding	Ptpn2	IPI	UniProtKB:P09581	Mouse	MGI:MGI:3629372|PMID:16705167
Molecular Function	GO:0005515	protein binding	Ptpn2	IPI	PR:Q3ZN08	Mouse	PMID:26026268
Molecular Function	GO:0019901	protein kinase binding	PTPN2	IPI	UniProtKB:P23458	Human	PMID:11909529
Molecular Function	GO:0019901	protein kinase binding	PTPN2	IPI	UniProtKB:P52333	Human	PMID:11909529
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN2	IMP		Human	PMID:11909529
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN2	EXP		Human	PMID:12138178
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN2	IDA		Human	PMID:12612081
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN2	IMP		Human	PMID:14966296
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn2	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn2	IDA		Mouse	PMID:15632081
Molecular Function	GO:0030971	receptor tyrosine kinase binding	PTPN2	IPI	UniProtKB:P08581	Human	PMID:18819921
Molecular Function	GO:0097677	STAT family protein binding	Ptpn2	IPI	PR:P42227	Mouse	PMID:26026268
Molecular Function	GO:0019905	syntaxin binding	PTPN2	IPI	UniProtKB:P56962	Human	PMID:23006999
Cellular Component	GO:0005829	cytosol	PTPN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PTPN2	IDA		Human	PMID:10940933
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	PTPN2	IDA		Human	PMID:23006999
Cellular Component	GO:0031904	endosome lumen	Ptpn2	IDA		Mouse	PMID:12612081
Cellular Component	GO:0005654	nucleoplasm	PTPN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Ptpn2	IDA		Mouse	MGI:MGI:5619464|PMID:21216966
Cellular Component	GO:0005634	nucleus	Ptpn2	IDA		Mouse	PMID:26026268
Cellular Component	GO:0005886	plasma membrane	PTPN2	IDA		Human	PMID:15592458
Biological Process	GO:0030183	B cell differentiation	Ptpn2	IMP		Mouse	MGI:MGI:1096020|PMID:9271584
Biological Process	GO:0030218	erythrocyte differentiation	Ptpn2	IMP		Mouse	MGI:MGI:1096020|PMID:9271584
Biological Process	GO:0042593	glucose homeostasis	Ptpn2	IMP		Mouse	MGI:MGI:4941441|PMID:20484139
Biological Process	GO:0038020	insulin receptor recycling	Ptpn2	IDA		Mouse	PMID:15632081
Biological Process	GO:0008286	insulin receptor signaling pathway	Ptpn2	IMP		Mouse	PMID:15632081
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPN2	IMP		Human	PMID:15592458
Biological Process	GO:0050922	negative regulation of chemotaxis	Ptpn2	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	PTPN2	IMP		Human	PMID:15592458
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Ptpn2	IMP		Mouse	MGI:MGI:3530208|PMID:15696169
Biological Process	GO:0050728	negative regulation of inflammatory response	Ptpn2	IMP		Mouse	MGI:MGI:3044093|PMID:14726372
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:4941441|PMID:20484139
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5488890|PMID:12612081
Biological Process	GO:1902206	negative regulation of interleukin-2-mediated signaling pathway	PTPN2	IMP		Human	PMID:11909529
Biological Process	GO:1902206	negative regulation of interleukin-2-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:3691503|PMID:11909529
Biological Process	GO:1902215	negative regulation of interleukin-4-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5493214|PMID:17210636
Biological Process	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:4941441|PMID:20484139
Biological Process	GO:0010888	negative regulation of lipid storage	Ptpn2	IMP		Mouse	MGI:MGI:4941441|PMID:20484139
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:3629372|PMID:16705167
Biological Process	GO:0045650	negative regulation of macrophage differentiation	Ptpn2	IMP		Mouse	MGI:MGI:3629372|PMID:16705167
Biological Process	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Biological Process	GO:1902233	negative regulation of positive thymic T cell selection	Ptpn2	IMP		Mouse	MGI:MGI:5320871|PMID:22080863
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	Ptpn2	IMP		Mouse	MGI:MGI:5619464|PMID:21216966
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5320871|PMID:22080863
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ptpn2	IPI	PR:Q3ZN08	Mouse	PMID:26026268
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:3530208|PMID:15696169
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	PTPN2	IMP		Human	PMID:11909529
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:3691503|PMID:11909529
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5493216|PMID:12138178
Biological Process	GO:0060336	negative regulation of type II interferon-mediated signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5493216|PMID:12138178
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	PTPN2	IMP		Human	PMID:12138178
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Ptpn2	IMP		Mouse	MGI:MGI:5493214|PMID:17210636
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPN2	IMP		Human	PMID:11909529
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPN2	IMP		Human	PMID:14966296
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Ptpn2	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Ptpn2	IMP		Mouse	MGI:MGI:5619464|PMID:21216966
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Ptpn2	IMP		Mouse	MGI:MGI:4941441|PMID:20484139
Biological Process	GO:1903899	positive regulation of PERK-mediated unfolded protein response	Ptpn2	IMP		Mouse	MGI:MGI:5619464|PMID:21216966
Biological Process	GO:0006470	protein dephosphorylation	Ptpn2	IMP		Mouse	PMID:15632081
Biological Process	GO:0006470	protein dephosphorylation	Ptpn2	IGI	MGI:MGI:1914488	Mouse	PMID:26026268
Biological Process	GO:0006470	protein dephosphorylation	Ptpn2	IDA		Mouse	PMID:26026268
Biological Process	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	PTPN2	IMP		Human	PMID:18819921
Biological Process	GO:0030217	T cell differentiation	Ptpn2	IMP		Mouse	MGI:MGI:1096020|PMID:9271584

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern