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Gene Ontology Browser
Term Detail
GO term:negative regulation of insulin receptor signaling pathway
Synonym: down regulation of insulin receptor signaling pathway
Synonym: down-regulation of insulin receptor signaling pathway
Synonym: downregulation of insulin receptor signaling pathway
Synonym: inhibition of insulin receptor signaling pathway
Synonym: negative regulation of insulin receptor signalling pathway
GO id:GO:0046627
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Number of paths to term: 317

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cell communication
                                                        is-anegative regulation of signal transduction
                                                                is-aextracellular negative regulation of signal transduction +
                                                                is-ametarhodopsin inactivation
                                                                is-anegative adaptation of signaling pathway +
                                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                                is-anegative regulation of apoptotic signaling pathway +
                                                                is-anegative regulation of auxin mediated signaling pathway
                                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                                is-anegative regulation of CD40 signaling pathway
                                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                                is-anegative regulation of ephrin receptor signaling pathway
                                                                is-anegative regulation of ERBB signaling pathway +
                                                                is-anegative regulation of Fas signaling pathway
                                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                                is-anegative regulation of glucose mediated signaling pathway
                                                                is-anegative regulation of glutamate receptor signaling pathway
                                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                                is-anegative regulation of integrin-mediated signaling pathway
                                                                is-anegative regulation of intracellular signal transduction +
                                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                                is-anegative regulation of nerve growth factor receptor activity
                                                                is-anegative regulation of netrin-activated signaling pathway
                                                                is-anegative regulation of neuronal signal transduction
                                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                                is-anegative regulation of Notch signaling pathway +
                                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                                is-anegative regulation of phosphorelay signal transduction system +
                                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                                is-anegative regulation of red or far-red light signaling pathway
                                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                                is-anegative regulation of Roundabout signaling pathway +
                                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                                is-anegative regulation of sevenless signaling pathway
                                                                is-anegative regulation of signal transduction by receptor internalization +
                                                                is-anegative regulation of signal transduction in absence of ligand +
                                                                is-anegative regulation of signal transduction in response to host +
                                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                                is-anegative regulation of SREBP signaling pathway +
                                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                                is-anegative regulation of Toll signaling pathway
                                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                                is-anegative regulation of Wnt signaling pathway +
                                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of response to stimulus
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of response to stimulus
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of signaling
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cell communication
                                                        is-anegative regulation of signal transduction
                                                                is-aextracellular negative regulation of signal transduction +
                                                                is-ametarhodopsin inactivation
                                                                is-anegative adaptation of signaling pathway +
                                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                                is-anegative regulation of apoptotic signaling pathway +
                                                                is-anegative regulation of auxin mediated signaling pathway
                                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                                is-anegative regulation of CD40 signaling pathway
                                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                                is-anegative regulation of ephrin receptor signaling pathway
                                                                is-anegative regulation of ERBB signaling pathway +
                                                                is-anegative regulation of Fas signaling pathway
                                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                                is-anegative regulation of glucose mediated signaling pathway
                                                                is-anegative regulation of glutamate receptor signaling pathway
                                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                                is-anegative regulation of integrin-mediated signaling pathway
                                                                is-anegative regulation of intracellular signal transduction +
                                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                                is-anegative regulation of nerve growth factor receptor activity
                                                                is-anegative regulation of netrin-activated signaling pathway
                                                                is-anegative regulation of neuronal signal transduction
                                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                                is-anegative regulation of Notch signaling pathway +
                                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                                is-anegative regulation of phosphorelay signal transduction system +
                                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                                is-anegative regulation of red or far-red light signaling pathway
                                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                                is-anegative regulation of Roundabout signaling pathway +
                                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                                is-anegative regulation of sevenless signaling pathway
                                                                is-anegative regulation of signal transduction by receptor internalization +
                                                                is-anegative regulation of signal transduction in absence of ligand +
                                                                is-anegative regulation of signal transduction in response to host +
                                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                                is-anegative regulation of SREBP signaling pathway +
                                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                                is-anegative regulation of Toll signaling pathway
                                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                                is-anegative regulation of Wnt signaling pathway +
                                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell communication
                                                is-anegative regulation of cell communication
                                                        is-anegative regulation of signal transduction
                                                                is-aextracellular negative regulation of signal transduction +
                                                                is-ametarhodopsin inactivation
                                                                is-anegative adaptation of signaling pathway +
                                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                                is-anegative regulation of apoptotic signaling pathway +
                                                                is-anegative regulation of auxin mediated signaling pathway
                                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                                is-anegative regulation of CD40 signaling pathway
                                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                                is-anegative regulation of ephrin receptor signaling pathway
                                                                is-anegative regulation of ERBB signaling pathway +
                                                                is-anegative regulation of Fas signaling pathway
                                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                                is-anegative regulation of glucose mediated signaling pathway
                                                                is-anegative regulation of glutamate receptor signaling pathway
                                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                                is-anegative regulation of integrin-mediated signaling pathway
                                                                is-anegative regulation of intracellular signal transduction +
                                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                                is-anegative regulation of nerve growth factor receptor activity
                                                                is-anegative regulation of netrin-activated signaling pathway
                                                                is-anegative regulation of neuronal signal transduction
                                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                                is-anegative regulation of Notch signaling pathway +
                                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                                is-anegative regulation of phosphorelay signal transduction system +
                                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                                is-anegative regulation of red or far-red light signaling pathway
                                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                                is-anegative regulation of Roundabout signaling pathway +
                                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                                is-anegative regulation of sevenless signaling pathway
                                                                is-anegative regulation of signal transduction by receptor internalization +
                                                                is-anegative regulation of signal transduction in absence of ligand +
                                                                is-anegative regulation of signal transduction in response to host +
                                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                                is-anegative regulation of SREBP signaling pathway +
                                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                                is-anegative regulation of Toll signaling pathway
                                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                                is-anegative regulation of Wnt signaling pathway +
                                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell communication
                                                is-aregulation of signal transduction
                                                        is-anegative regulation of signal transduction
                                                                is-aextracellular negative regulation of signal transduction +
                                                                is-ametarhodopsin inactivation
                                                                is-anegative adaptation of signaling pathway +
                                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                                is-anegative regulation of apoptotic signaling pathway +
                                                                is-anegative regulation of auxin mediated signaling pathway
                                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                                is-anegative regulation of CD40 signaling pathway
                                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                                is-anegative regulation of ephrin receptor signaling pathway
                                                                is-anegative regulation of ERBB signaling pathway +
                                                                is-anegative regulation of Fas signaling pathway
                                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                                is-anegative regulation of glucose mediated signaling pathway
                                                                is-anegative regulation of glutamate receptor signaling pathway
                                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                                is-anegative regulation of integrin-mediated signaling pathway
                                                                is-anegative regulation of intracellular signal transduction +
                                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                                is-anegative regulation of nerve growth factor receptor activity
                                                                is-anegative regulation of netrin-activated signaling pathway
                                                                is-anegative regulation of neuronal signal transduction
                                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                                is-anegative regulation of Notch signaling pathway +
                                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                                is-anegative regulation of phosphorelay signal transduction system +
                                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                                is-anegative regulation of red or far-red light signaling pathway
                                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                                is-anegative regulation of Roundabout signaling pathway +
                                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                                is-anegative regulation of sevenless signaling pathway
                                                                is-anegative regulation of signal transduction by receptor internalization +
                                                                is-anegative regulation of signal transduction in absence of ligand +
                                                                is-anegative regulation of signal transduction in response to host +
                                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                                is-anegative regulation of SREBP signaling pathway +
                                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                                is-anegative regulation of Toll signaling pathway
                                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                                is-anegative regulation of Wnt signaling pathway +
                                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell communication
                                                is-aregulation of signal transduction
                                                        is-aregulation of insulin receptor signaling pathway
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cellular response to insulin stimulus
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cellular response to insulin stimulus
                                                is-aregulation of insulin receptor signaling pathway
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        is-ainsulin receptor signaling pathway
                                                                                is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                                is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                                is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                                negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                                regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        is-ainsulin receptor signaling pathway
                                                                                regulatesregulation of insulin receptor signaling pathway
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                negatively-regulatesnegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                regulatesregulation of signal transduction
                                                        is-anegative regulation of signal transduction
                                                                is-aextracellular negative regulation of signal transduction +
                                                                is-ametarhodopsin inactivation
                                                                is-anegative adaptation of signaling pathway +
                                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                                is-anegative regulation of apoptotic signaling pathway +
                                                                is-anegative regulation of auxin mediated signaling pathway
                                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                                is-anegative regulation of CD40 signaling pathway
                                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                                is-anegative regulation of ephrin receptor signaling pathway
                                                                is-anegative regulation of ERBB signaling pathway +
                                                                is-anegative regulation of Fas signaling pathway
                                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                                is-anegative regulation of glucose mediated signaling pathway
                                                                is-anegative regulation of glutamate receptor signaling pathway
                                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                                is-anegative regulation of integrin-mediated signaling pathway
                                                                is-anegative regulation of intracellular signal transduction +
                                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                                is-anegative regulation of nerve growth factor receptor activity
                                                                is-anegative regulation of netrin-activated signaling pathway
                                                                is-anegative regulation of neuronal signal transduction
                                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                                is-anegative regulation of Notch signaling pathway +
                                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                                is-anegative regulation of phosphorelay signal transduction system +
                                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                                is-anegative regulation of red or far-red light signaling pathway
                                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                                is-anegative regulation of Roundabout signaling pathway +
                                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                                is-anegative regulation of sevenless signaling pathway
                                                                is-anegative regulation of signal transduction by receptor internalization +
                                                                is-anegative regulation of signal transduction in absence of ligand +
                                                                is-anegative regulation of signal transduction in response to host +
                                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                                is-anegative regulation of SREBP signaling pathway +
                                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                                is-anegative regulation of Toll signaling pathway
                                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                                is-anegative regulation of Wnt signaling pathway +
                                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                regulatesregulation of signal transduction
                                                        is-aregulation of insulin receptor signaling pathway
                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-anegative regulation of response to stimulus
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-anegative regulation of response to stimulus
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of cellular response to insulin stimulus
                                                is-anegative regulation of cellular response to insulin stimulus
                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of cellular response to insulin stimulus
                                                is-aregulation of insulin receptor signaling pathway
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of signal transduction
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of signal transduction
                                                is-aregulation of insulin receptor signaling pathway
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of signaling
                                        is-anegative regulation of signaling
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of signaling
                                        is-aregulation of signal transduction
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of signaling
                                        is-aregulation of signal transduction
                                                is-aregulation of insulin receptor signaling pathway
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to nitrogen compound
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                is-ainsulin receptor signaling pathway
                                                                                        is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                                        is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                                        is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                                        negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                                        regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to nitrogen compound
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                is-ainsulin receptor signaling pathway
                                                                                        regulatesregulation of insulin receptor signaling pathway
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to nitrogen compound
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                negatively-regulatesnegative regulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to nitrogen compound
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                regulatesregulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of cellular response to insulin stimulus
                                                                                                is-anegative regulation of glucose import in response to insulin stimulus
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to nitrogen compound
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                regulatesregulation of cellular response to insulin stimulus
                                                                                        is-aregulation of insulin receptor signaling pathway
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        is-ainsulin receptor signaling pathway
                                                                                is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                                is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                                is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                                negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                                regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        is-ainsulin receptor signaling pathway
                                                                                regulatesregulation of insulin receptor signaling pathway
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        negatively-regulatesnegative regulation of cellular response to insulin stimulus
                                                                                is-anegative regulation of glucose import in response to insulin stimulus
                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        regulatesregulation of cellular response to insulin stimulus
                                                                                is-anegative regulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to hormone stimulus
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        regulatesregulation of cellular response to insulin stimulus
                                                                                is-aregulation of insulin receptor signaling pathway
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                is-ainsulin receptor signaling pathway
                                                                                        is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                                        is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                                        is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                                        negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                                        regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                is-ainsulin receptor signaling pathway
                                                                                        regulatesregulation of insulin receptor signaling pathway
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                negatively-regulatesnegative regulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                regulatesregulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of cellular response to insulin stimulus
                                                                                                is-anegative regulation of glucose import in response to insulin stimulus
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to organonitrogen compound
                                                        is-acellular response to peptide
                                                                is-acellular response to peptide hormone stimulus
                                                                        is-acellular response to insulin stimulus
                                                                                regulatesregulation of cellular response to insulin stimulus
                                                                                        is-aregulation of insulin receptor signaling pathway
                                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen-containing compound
                                                is-acellular response to peptide
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        is-ainsulin receptor signaling pathway
                                                                                is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                                is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                                is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                                negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                                regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen-containing compound
                                                is-acellular response to peptide
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        is-ainsulin receptor signaling pathway
                                                                                regulatesregulation of insulin receptor signaling pathway
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen-containing compound
                                                is-acellular response to peptide
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        negatively-regulatesnegative regulation of cellular response to insulin stimulus
                                                                                is-anegative regulation of glucose import in response to insulin stimulus
                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen-containing compound
                                                is-acellular response to peptide
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        regulatesregulation of cellular response to insulin stimulus
                                                                                is-anegative regulation of cellular response to insulin stimulus
                                                                                        is-anegative regulation of glucose import in response to insulin stimulus
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen-containing compound
                                                is-acellular response to peptide
                                                        is-acellular response to peptide hormone stimulus
                                                                is-acellular response to insulin stimulus
                                                                        regulatesregulation of cellular response to insulin stimulus
                                                                                is-aregulation of insulin receptor signaling pathway
                                                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-ainsulin receptor signaling pathway
                                                                        is-ainsulin receptor signaling pathway involved in dauer larval development
                                                                        is-ainsulin receptor signaling pathway involved in determination of adult lifespan +
                                                                        is-ainsulin receptor signaling pathway via phosphatidylinositol 3-kinase
                                                                        negatively-regulatesnegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                        positively-regulatespositive regulation of insulin receptor signaling pathway +
                                                                        regulatesregulation of insulin receptor signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-ainsulin receptor signaling pathway
                                                                        regulatesregulation of insulin receptor signaling pathway
                                                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                                                is-apositive regulation of insulin receptor signaling pathway +
                                                                                is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        negatively-regulatesnegative regulation of signal transduction
                                                is-aextracellular negative regulation of signal transduction +
                                                is-ametarhodopsin inactivation
                                                is-anegative adaptation of signaling pathway +
                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                is-anegative regulation of apoptotic signaling pathway +
                                                is-anegative regulation of auxin mediated signaling pathway
                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                is-anegative regulation of CD40 signaling pathway
                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                is-anegative regulation of ephrin receptor signaling pathway
                                                is-anegative regulation of ERBB signaling pathway +
                                                is-anegative regulation of Fas signaling pathway
                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                is-anegative regulation of glucose mediated signaling pathway
                                                is-anegative regulation of glutamate receptor signaling pathway
                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                is-anegative regulation of integrin-mediated signaling pathway
                                                is-anegative regulation of intracellular signal transduction +
                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                is-anegative regulation of nerve growth factor receptor activity
                                                is-anegative regulation of netrin-activated signaling pathway
                                                is-anegative regulation of neuronal signal transduction
                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                is-anegative regulation of Notch signaling pathway +
                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                is-anegative regulation of phosphorelay signal transduction system +
                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                is-anegative regulation of red or far-red light signaling pathway
                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                is-anegative regulation of Roundabout signaling pathway +
                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                is-anegative regulation of sevenless signaling pathway
                                                is-anegative regulation of signal transduction by receptor internalization +
                                                is-anegative regulation of signal transduction in absence of ligand +
                                                is-anegative regulation of signal transduction in response to host +
                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                is-anegative regulation of smoothened signaling pathway +
                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                is-anegative regulation of SREBP signaling pathway +
                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                is-anegative regulation of Toll signaling pathway
                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                is-anegative regulation of Wnt signaling pathway +
                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-aregulation of insulin receptor signaling pathway
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-apositive regulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway involved in determination of adult lifespan +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        negatively-regulatesnegative regulation of cellular process
                                is-anegative regulation of cell communication
                                        is-anegative regulation of signal transduction
                                                is-aextracellular negative regulation of signal transduction +
                                                is-ametarhodopsin inactivation
                                                is-anegative adaptation of signaling pathway +
                                                is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                is-anegative regulation of abscisic acid-activated signaling pathway
                                                is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                is-anegative regulation of apoptotic signaling pathway +
                                                is-anegative regulation of auxin mediated signaling pathway
                                                is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-anegative regulation of brassinosteroid mediated signaling pathway
                                                is-anegative regulation of CD40 signaling pathway
                                                is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                is-anegative regulation of cytokine-mediated signaling pathway +
                                                is-anegative regulation of cytokinin-activated signaling pathway
                                                is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                is-anegative regulation of ephrin receptor signaling pathway
                                                is-anegative regulation of ERBB signaling pathway +
                                                is-anegative regulation of Fas signaling pathway
                                                is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                is-anegative regulation of gibberellic acid mediated signaling pathway
                                                is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                is-anegative regulation of glucocorticoid mediated signaling pathway
                                                is-anegative regulation of glucose mediated signaling pathway
                                                is-anegative regulation of glutamate receptor signaling pathway
                                                is-anegative regulation of growth hormone receptor signaling pathway
                                                is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                is-anegative regulation of integrin-mediated signaling pathway
                                                is-anegative regulation of intracellular signal transduction +
                                                is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                is-anegative regulation of nerve growth factor receptor activity
                                                is-anegative regulation of netrin-activated signaling pathway
                                                is-anegative regulation of neuronal signal transduction
                                                is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                is-anegative regulation of Notch signaling pathway +
                                                is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                is-anegative regulation of phosphorelay signal transduction system +
                                                is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                is-anegative regulation of red or far-red light signaling pathway
                                                is-anegative regulation of retinoic acid receptor signaling pathway
                                                is-anegative regulation of Roundabout signaling pathway +
                                                is-anegative regulation of semaphorin-plexin signaling pathway
                                                is-anegative regulation of sevenless signaling pathway
                                                is-anegative regulation of signal transduction by receptor internalization +
                                                is-anegative regulation of signal transduction in absence of ligand +
                                                is-anegative regulation of signal transduction in response to host +
                                                is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                is-anegative regulation of smoothened signaling pathway +
                                                is-anegative regulation of sphingolipid mediated signaling pathway
                                                is-anegative regulation of SREBP signaling pathway +
                                                is-anegative regulation of thyroid hormone mediated signaling pathway
                                                is-anegative regulation of Toll signaling pathway
                                                is-anegative regulation of toll-like receptor signaling pathway +
                                                is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                is-anegative regulation of vitamin D receptor signaling pathway
                                                is-anegative regulation of Wnt signaling pathway +
                                                is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        negatively-regulatesnegative regulation of cellular process
                                is-anegative regulation of cellular response to insulin stimulus
                                        is-anegative regulation of glucose import in response to insulin stimulus
                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-anegative regulation of cellular process
                                        is-anegative regulation of cell communication
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-anegative regulation of cellular process
                                        is-anegative regulation of cellular response to insulin stimulus
                                                is-anegative regulation of glucose import in response to insulin stimulus
                                                is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                        is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                        is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-aregulation of cell communication
                                        is-anegative regulation of cell communication
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
                                                        is-anegative regulation of glucose mediated signaling pathway
                                                        is-anegative regulation of glutamate receptor signaling pathway
                                                        is-anegative regulation of growth hormone receptor signaling pathway
                                                        is-anegative regulation of hepatocyte growth factor receptor signaling pathway
                                                        is-anegative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                        is-anegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                                        is-anegative regulation of insulin receptor signaling pathway [GO:0046627] (34 genes, 36 annotations)
                                                                is-anegative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                is-anegative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
                                                        is-anegative regulation of insulin-like growth factor receptor signaling pathway
                                                        is-anegative regulation of integrin-mediated signaling pathway
                                                        is-anegative regulation of intracellular signal transduction +
                                                        is-anegative regulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-anegative regulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-anegative regulation of nerve growth factor receptor activity
                                                        is-anegative regulation of netrin-activated signaling pathway
                                                        is-anegative regulation of neuronal signal transduction
                                                        is-anegative regulation of neurotrophin TRK receptor signaling pathway
                                                        is-anegative regulation of Notch signaling pathway +
                                                        is-anegative regulation of peptidoglycan recognition protein signaling pathway
                                                        is-anegative regulation of peroxisome proliferator activated receptor signaling pathway
                                                        is-anegative regulation of phosphorelay signal transduction system +
                                                        is-anegative regulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-anegative regulation of red or far-red light signaling pathway
                                                        is-anegative regulation of retinoic acid receptor signaling pathway
                                                        is-anegative regulation of Roundabout signaling pathway +
                                                        is-anegative regulation of semaphorin-plexin signaling pathway
                                                        is-anegative regulation of sevenless signaling pathway
                                                        is-anegative regulation of signal transduction by receptor internalization +
                                                        is-anegative regulation of signal transduction in absence of ligand +
                                                        is-anegative regulation of signal transduction in response to host +
                                                        is-anegative regulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-anegative regulation of sphingolipid mediated signaling pathway
                                                        is-anegative regulation of SREBP signaling pathway +
                                                        is-anegative regulation of thyroid hormone mediated signaling pathway
                                                        is-anegative regulation of Toll signaling pathway
                                                        is-anegative regulation of toll-like receptor signaling pathway +
                                                        is-anegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-anegative regulation of vascular endothelial growth factor receptor signaling pathway
                                                        is-anegative regulation of vascular endothelial growth factor signaling pathway
                                                        is-anegative regulation of vitamin D receptor signaling pathway
                                                        is-anegative regulation of Wnt signaling pathway +
                                                        is-atermination of signal transduction +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-aregulation of cell communication
                                        is-aregulation of signal transduction
                                                is-anegative regulation of signal transduction
                                                        is-aextracellular negative regulation of signal transduction +
                                                        is-ametarhodopsin inactivation
                                                        is-anegative adaptation of signaling pathway +
                                                        is-anegative regulation by symbiont of host cAMP-mediated signal transduction +
                                                        is-anegative regulation by symbiont of host salicylic acid-mediated defense response +
                                                        is-anegative regulation of abscisic acid-activated signaling pathway
                                                        is-anegative regulation of anti-Mullerian hormone signaling pathway
                                                        is-anegative regulation of antigen receptor-mediated signaling pathway +
                                                        is-anegative regulation of apoptotic signaling pathway +
                                                        is-anegative regulation of auxin mediated signaling pathway
                                                        is-anegative regulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-anegative regulation of brassinosteroid mediated signaling pathway
                                                        is-anegative regulation of CD40 signaling pathway
                                                        is-anegative regulation of corticotropin-releasing hormone receptor activity
                                                        is-anegative regulation of cytokine-mediated signaling pathway +
                                                        is-anegative regulation of cytokinin-activated signaling pathway
                                                        is-anegative regulation of endoplasmic reticulum unfolded protein response
                                                        is-anegative regulation of ephrin receptor signaling pathway
                                                        is-anegative regulation of ERBB signaling pathway +
                                                        is-anegative regulation of Fas signaling pathway
                                                        is-anegative regulation of fibroblast growth factor receptor signaling pathway +
                                                        is-anegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-anegative regulation of gibberellic acid mediated signaling pathway
                                                        is-anegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                        is-anegative regulation of glucocorticoid mediated signaling pathway
       &nb