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Ptpn2
Gene Detail
 Symbol
Name
ID
Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806
Synonyms Ptpt, TC-PTP
Feature Type protein coding gene
Genetic Map
Chromosome 18
40.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:67665511-67724595 bp, - strand
From VEGA annotation of GRCm38

  59085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 1/2 types
Gene Tree: Ptpn2

Human
homologs
Human Homolog PTPN2, protein tyrosine phosphatase, non-receptor type 2
NCBI Gene ID 5771
neXtProt AC  NX_P17706
Human Synonyms  PTN2, PTPT, TCELLPTP, TCPTP, TC-PTP
Human Chr (Location)  18p11.3-p11.2; chr18:12785478-12884338 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(41) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease.
 
Phenotype Images(3)
Interactions
Ptpn2 interacts with 283 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process B cell differentiation, dephosphorylation, ...
Component cytoplasm, endoplasmic reticulum, ...
Function hydrolase activity, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (38)    Tissues (21)    Images (5)
Theiler Stages: 13, 16, 19, 21, 23, 26, 28
Assay TypeResults
RNA in situ 4
Northern blot 18
Western blot 9
RT-PCR 7
cDNA source data(117)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) cDNA(118) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000029831 (Evidence)
Ensembl Gene ModelENSMUSG00000024539 (Evidence)
Entrez Gene19255 (Evidence)
UniGene260433
DFCITC1575065, TC1589090, TC1613835
DoTSDT.101389419, DT.534791, DT.55151032, DT.94261985
NIA Mouse Gene IndexU038523, U338635
EC3.1.3.48
Consensus CDS ProjectCCDS37851.1, CCDS50311.1
International Mouse Knockout Project StatusPtpn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029831 VEGA Gene Model | MGI Sequence Detail 59085 C57BL/6J ±  kb
transcript OTTMUST00000074035 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000038403 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013454 tyrosine-protein phosphatase non-receptor type 2
References (Earliest) J:1925 Mosinger B Jr, et al., Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):499-503
(Latest) J:206438 Wiede F, et al., PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun. 2014;5:3073
All references(79)
Other
accession IDs
MGD-MRK-13675, MGD-MRK-13686, MGI:2147211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory