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Ptpn2
Gene Detail
Symbol

Name
ID
Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806
Synonyms
Ptpt, TC-PTP
Feature Type
protein coding gene
Genetic Map
Chromosome 18
40.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:67665511-67724595 bp, - strand
From VEGA annotation of GRCm38

  59085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPN2
Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 1/2 types
Gene Tree: Ptpn2

Human
homologs
PTPN2, protein tyrosine phosphatase, non-receptor type 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5771
neXtProt AC: NX_P17706

Human Synonyms: PTN2, PTPT, TCELLPTP, TCPTP, TC-PTP

Human Chr (Location): 18p11.3-p11.2; chr18:12785478-12884335 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(41) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease.
 
Phenotype Images(3)
Interactions
Ptpn2 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process B cell differentiation, dephosphorylation, ...
Component cytoplasm, endoplasmic reticulum, ...
Function hydrolase activity, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (38)    Tissues (22)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
Northern blot 18
Western blot 9
RT-PCR 7
cDNA source data(117)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ptpn2 ; ZFIN ptpn2a, ptpn2b    NEW 
Molecular
reagents
All nucleic(119) cDNA(118) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000029831 (Evidence)
Ensembl Gene Model ENSMUSG00000024539 (Evidence)
Entrez Gene 19255 (Evidence)
UniGene 260433
DFCI TC1575065, TC1589090, TC1613835
DoTS DT.101389419, DT.534791, DT.55151032, DT.94261985
NIA Mouse Gene Index U038523, U338635
EC 3.1.3.48
Consensus CDS Project CCDS37851.1, CCDS50311.1
International Mouse Phenotyping Consortium Status Ptpn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029831 VEGA Gene Model | MGI Sequence Detail 59085 C57BL/6J ±  kb
transcript OTTMUST00000074035 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000038403 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
InterPro IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
InterPro IPR000242 PTP type protein phosphatase
InterPro IPR000387 Tyrosine specific protein phosphatases domain
Protein Ontology PR:000013454 tyrosine-protein phosphatase non-receptor type 2
References
(Earliest) J:1925 Mosinger B Jr, et al., Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):499-503
(Latest) J:219581 Dodd GT, et al., Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15;160(1-2):88-104
All references(81)
Other
accession IDs
MGD-MRK-13675, MGD-MRK-13686, MGI:2147211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory