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Ptpn2 Gene Detail
Summary
  • Symbol
    Ptpn2
  • Name
    protein tyrosine phosphatase, non-receptor type 2
  • Synonyms
    Ptpt, TC-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97806
    NCBI Gene: 19255
  • Gene Overview
    MyGene.info: PTPN2
Location & Maps
more
  • Sequence Map
    Chr18:67665511-67724595 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 40.06 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTPN2, protein tyrosine phosphatase, non-receptor type 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPN2, protein tyrosine phosphatase, non-receptor type 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PTN2, PTPT, TCELLPTP, TCPTP, TC-PTP
  • Links
    NCBI Gene ID: 5771
    neXtProt AC: NX_P17706

  • Chr Location
    18p11.3-p11.2; chr18:12785478-12884335 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    96 phenotypes from 5 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    41
  • Targeted
    6
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029831 VEGA Gene Model | MGI Sequence Detail 59085 C57BL/6J ±  kb
transcript OTTMUST00000074035 VEGA | MGI Sequence Detail 2667 Not Applicable  
polypeptide OTTMUSP00000038403 VEGA | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    410 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013454 tyrosine-protein phosphatase non-receptor type 2
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 119
    cDNA 118
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-13675, MGD-MRK-13686, MGI:2147211
References
more
  • Summaries
    All 80
    Developmental Gene Expression 4
    Gene Ontology 19
    Phenotypes 30
  • Earliest
    J:1925 Mosinger B Jr, et al., Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):499-503
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory