Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPN1
  • Mouse genes Ptpn1
  • Rat genes Ptpn1
  • Zfish genes ptpn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PTPN1	HDA		Human	PMID:25468996
Molecular Function	GO:0019899	enzyme binding	PTPN1	IPI	UniProtKB:P32929	Human	PMID:22169477
Molecular Function	GO:0046875	ephrin receptor binding	PTPN1	IPI	UniProtKB:P29320	Human	PMID:21135139
Molecular Function	GO:0005158	insulin receptor binding	Ptpn1	IMP		Rat	PMID:12850498|RGD:1580595
Molecular Function	GO:0005158	insulin receptor binding	Ptpn1	IDA		Rat	PMID:7711057|RGD:2293185
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P35570	Human	PMID:10660596
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P62993	Human	PMID:10660596
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P56945	Human	PMID:10889023
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:11007774
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P15116	Human	PMID:11106648
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:11163213
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:11506178
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:11579209
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:O60674	Human	PMID:11694501
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:O60674	Human	PMID:11970898
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P40763	Human	PMID:11970898
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P62994	Human	PMID:12023880
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q61140	Human	PMID:12023880
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q63768	Human	PMID:12023880
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9WUD9	Human	PMID:12023880
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q03135	Human	PMID:12176037
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P04629	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P42229	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q16288	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P05622	Human	PMID:12614164
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P09619	Human	PMID:12614164
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:12634852
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:O43561	Human	PMID:12857726
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:12857726
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P10912	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P19235	Human	PMID:14527337
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:14722096
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:15588987
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:O60674	Human	PMID:15821101
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P40763	Human	PMID:15821101
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:15866871
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P56945	Human	PMID:15866871
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9H1D0	Human	PMID:15894168
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08069	Human	PMID:15976035
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P05106	Human	PMID:16115959
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:16115959
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213-1	Human	PMID:16271887
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q03135	Human	PMID:16388599
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08581	Human	PMID:16537444
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:16537444
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:16582879
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q61140	Human	PMID:16644720
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:16926280
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08069	Human	PMID:16926280
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:17092689
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:17092689
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P10686	Human	PMID:17128263
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:17159996
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P63166	Human	PMID:17159996
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9H1D0	Human	PMID:17197020
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08922	Human	PMID:17416557
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:17481567
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:17974954
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q14247	Human	PMID:18387954
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P05622	Human	PMID:18515860
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08581	Human	PMID:18579758
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:19029027
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P09619	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P07384	Human	PMID:19712109
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:O60674	Human	PMID:21806020
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P05556	Human	PMID:21806020
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:21806020
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08581	Human	PMID:22789536
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P10599	Human	PMID:24976139
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:25796184
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9WUD9	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P57054	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q96HV5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q9NPL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08069	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q16288	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:8702689
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P62994	Human	PMID:8940134
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q63767	Human	PMID:8940134
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q63768	Human	PMID:8940134
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P06213	Human	PMID:8999839
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P08069	Human	PMID:8999839
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:9050838
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P00533	Human	PMID:9355745
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P09619	Human	PMID:9355745
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P07384	Human	PMID:9407132
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P56945	Human	PMID:9407132
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P34152	Human	PMID:9418872
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P56945	Human	PMID:9418872
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q61140	Human	PMID:9418872
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:Q8VI36	Human	PMID:9418872
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P11274-1	Human	PMID:9566916
Molecular Function	GO:0005515	protein binding	PTPN1	IPI	UniProtKB:P12931	Human	PMID:9600099
Molecular Function	GO:0005515	protein binding	Ptpn1	IPI	UniProtKB:P00533	Rat	PMID:7685104|RGD:8554565
Molecular Function	GO:0005515	protein binding	Ptpn1	IPI	UniProtKB:P00533	Rat	PMID:7693694|RGD:8554805
Molecular Function	GO:0005515	protein binding	Ptpn1	IPI	UniProtKB:P00533	Rat	PMID:8621392|RGD:8554555
Molecular Function	GO:0005515	protein binding	Ptpn1	IPI	UniProtKB:Q63767	Rat	PMID:8940134|RGD:1625244
Molecular Function	GO:0019901	protein kinase binding	PTPN1	IPI	UniProtKB:Q9NZJ5	Human	PMID:22169477
Molecular Function	GO:0051721	protein phosphatase 2A binding	Ptpn1	IPI	RGD:3380	Rat	PMID:17897622|RGD:8693394
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN1	IDA		Human	PMID:18074158
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN1	IDA		Human	PMID:21707536
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN1	IDA		Human	PMID:22169477
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn1	IDA		Mouse	PMID:15632081
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn1	IMP	MGI:MGI:2384135	Mouse	PMID:17068137
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn1	IMP		Rat	PMID:17563729|RGD:2289367
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn1	IDA		Rat	PMID:7711057|RGD:2293185
Molecular Function	GO:0030971	receptor tyrosine kinase binding	PTPN1	IPI	UniProtKB:P08581	Human	PMID:18819921
Molecular Function	GO:0003723	RNA binding	PTPN1	HDA		Human	PMID:22658674
Molecular Function	GO:0008270	zinc ion binding	PTPN1	IDA		Human	PMID:18074158
Cellular Component	GO:0005737	cytoplasm	Ptpn1	IDA		Mouse	MGI:MGI:5619464|PMID:21216966
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	PTPN1	IDA		Human	PMID:1739967
Cellular Component	GO:0031410	cytoplasmic vesicle	Ptpn1	IDA		Rat	PMID:17563729|RGD:2289367
Cellular Component	GO:0005829	cytosol	Ptpn1	IDA		Rat	PMID:7711057|RGD:2293185
Cellular Component	GO:0005769	early endosome	PTPN1	IDA		Human	PMID:21135139
Cellular Component	GO:0005769	early endosome	Ptpn1	IDA		Mouse	MGI:MGI:5490930|PMID:23639442
Cellular Component	GO:0005783	endoplasmic reticulum	PTPN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031904	endosome lumen	Ptpn1	IDA		Mouse	PMID:23639442
Cellular Component	GO:0030061	mitochondrial crista	Ptpn1	IDA		Rat	PMID:18583343|RGD:15023487
Cellular Component	GO:0005759	mitochondrial matrix	Ptpn1	IDA		Rat	PMID:18583343|RGD:15023487
Cellular Component	GO:0005886	plasma membrane	PTPN1	IDA		Human	PMID:21135139
Cellular Component	GO:0032991	protein-containing complex	PTPN1	IDA		Human	PMID:28246125
Cellular Component	GO:0097443	sorting endosome	Ptpn1	IDA		Mouse	MGI:MGI:5490930|PMID:23639442
Biological Process	GO:0031532	actin cytoskeleton reorganization	PTPN1	IMP		Human	PMID:21135139
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	PTPN1	IDA		Human	PMID:22169477
Biological Process	GO:0038020	insulin receptor recycling	Ptpn1	IMP	MGI:MGI:2384135	Mouse	PMID:17068137
Biological Process	GO:0008286	insulin receptor signaling pathway	Ptpn1	IMP		Mouse	PMID:15632081
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	Ptpn1	IMP		Mouse	MGI:MGI:5616322|PMID:15465829
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Ptpn1	IMP		Mouse	MGI:MGI:5619464|PMID:21216966
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Ptpn1	IGI	UniProtKB:P97333	Mouse	MGI:MGI:5490930|PMID:23639442
Biological Process	GO:0043407	negative regulation of MAP kinase activity	PTPN1	IMP		Human	PMID:22045810
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	PTPN1	IDA		Human	PMID:21216966
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	Ptpn1	IMP		Mouse	MGI:MGI:5619464|PMID:21216966
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Ptpn1	IGI	UniProtKB:P97333	Mouse	MGI:MGI:5490930|PMID:23639442
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPN1	IMP		Human	PMID:14966296
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPN1	IDA		Human	PMID:21135139
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Ptpn1	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Ptpn1	IGI	UniProtKB:P97333	Mouse	MGI:MGI:5490930|PMID:23639442
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	PTPN1	IMP		Human	PMID:14966296
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	Ptpn1	IMP		Mouse	MGI:MGI:3029644|PMID:14966296
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Ptpn1	IMP		Mouse	MGI:MGI:5616322|PMID:15465829
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	PTPN1	IDA		Human	PMID:21216966
Biological Process	GO:2000646	positive regulation of receptor catabolic process	PTPN1	IMP		Human	PMID:22045810
Biological Process	GO:0006470	protein dephosphorylation	PTPN1	IMP		Human	PMID:22045810
Biological Process	GO:0006470	protein dephosphorylation	Ptpn1	IMP		Mouse	PMID:15632081
Biological Process	GO:0006470	protein dephosphorylation	Ptpn1	IMP		Rat	PMID:17563729|RGD:2289367
Biological Process	GO:0006470	protein dephosphorylation	Ptpn1	IDA		Rat	PMID:7711057|RGD:2293185
Biological Process	GO:0030100	regulation of endocytosis	PTPN1	IDA		Human	PMID:21135139
Biological Process	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	PTPN1	IMP		Human	PMID:18819921
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Ptpn1	IMP		Rat	PMID:12941932|RGD:1625241
Biological Process	GO:0033157	regulation of intracellular protein transport	PTPN1	IMP		Human	PMID:22045810
Biological Process	GO:0009966	regulation of signal transduction	PTPN1	IMP		Human	PMID:21135139
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Ptpn1	IMP		Mouse	MGI:MGI:5616322|PMID:15465829

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern