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Ptpn1 Gene Detail
Summary
  • Symbol
    Ptpn1
  • Name
    protein tyrosine phosphatase, non-receptor type 1
  • Synonyms
    PTP1B, PTP-1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97805
    NCBI Gene: 19246
  • Gene Overview
    MyGene.info: PTPN1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167932057-167979385 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.99 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97805
protein coding gene Chr2:167932009-167979385 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026919
protein coding gene Chr2:173724873-173775604 (+)
A/J MGP_AJ_G0026886
protein coding gene Chr2:166556748-166604483 (+)
AKR/J MGP_AKRJ_G0026857
protein coding gene Chr2:171520660-171567871 (+)
BALB/cJ MGP_BALBcJ_G0026895
protein coding gene Chr2:166910206-166957180 (+)
C3H/HeJ MGP_C3HHeJ_G0026637
protein coding gene Chr2:171894849-171945174 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027342
protein coding gene Chr2:178790376-178837502 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024713
protein coding gene Chr2:159857669-159905458 (+)
CAST/EiJ MGP_CASTEiJ_G0026095
protein coding gene Chr2:172363852-172411038 (+)
CBA/J MGP_CBAJ_G0026614
protein coding gene Chr2:185370315-185419463 (+)
DBA/2J MGP_DBA2J_G0026752
protein coding gene Chr2:165657490-165704458 (+)
FVB/NJ MGP_FVBNJ_G0026718
protein coding gene Chr2:164211224-164258981 (+)
LP/J MGP_LPJ_G0026853
protein coding gene Chr2:173734685-173783486 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026737
protein coding gene Chr2:188696076-188743768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027399
protein coding gene Chr2:171456077-171503381 (+)
PWK/PhJ MGP_PWKPhJ_G0025832
protein coding gene Chr2:165344104-165392289 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025633
protein coding gene Chr2:170405143-170455073 (+)
WSB/EiJ MGP_WSBEiJ_G0026168
protein coding gene Chr2:172367548-172416050 (+)



Homology
more
  • Human Ortholog
    PTPN1, protein tyrosine phosphatase, non-receptor type 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN1, protein tyrosine phosphatase, non-receptor type 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTP1B
  • Links
    NCBI Gene ID: 5770
    neXtProt AC: NX_P18031
    UniProt: P18031

  • Chr Location
    20q13.13; chr20:50510321-50584762 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PTPN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    22 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027540 Ensembl Gene Model | MGI Sequence Detail 47329 C57BL/6J ±  kb
    transcript ENSMUST00000029053 Ensembl | MGI Sequence Detail 4213 Not Applicable  
    polypeptide ENSMUSP00000029053 Ensembl | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 1
      cDNA 129
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13674
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 89
    • Earliest
      J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
    • Latest
      J:264690 Besnier M, et al., Protein tyrosine phosphatase 1B inactivation limits aging-associated heart failure in mice. Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1279-H1288

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory