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Ptpn1
Gene Detail
 Symbol
Name
ID
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
MGI:97805
Synonyms PTP1B, PTP-1B
Feature Type protein coding gene
Genetic Map
Chromosome 2
87.99 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:167932057-167979385 bp, + strand
From VEGA annotation of GRCm38

  47329 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 1/2 types
Gene Tree: Ptpn1

Human
homologs
Human Homolog PTPN1, protein tyrosine phosphatase, non-receptor type 1
NCBI Gene ID 5770
neXtProt AC  NX_P18031
Human Synonyms  PTP1B
Human Chr (Location)  20q13.1-q13.2; chr20:50510321-50584762 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.
 
Interactions
Ptpn1 interacts with 239 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process actin cytoskeleton reorganization, dephosphorylation, ...
Component cytoplasmic vesicle, cytosol, ...
Function enzyme binding, ephrin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (10)    Tissues (6)   
Theiler Stages: 21, 23, 26, 27, 28
Assay TypeResults
Western blot 9
RT-PCR 1
cDNA source data(129)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(130) cDNA(129) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015956 (Evidence)
Ensembl Gene ModelENSMUSG00000027540 (Evidence)
Entrez Gene19246 (Evidence)
UniGene277916
DFCITC1572840, TC1602046, TC1630391, TC1678078, TC1772302
DoTSDT.101401137, DT.110682341, DT.536218, DT.97414531
NIA Mouse Gene IndexU002857
EC3.1.3.48
Consensus CDS ProjectCCDS17107.1
International Mouse Knockout Project StatusPtpn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015956 VEGA Gene Model | MGI Sequence Detail 47329 C57BL/6J ±  kb
transcript OTTMUST00000037925 VEGA | MGI Sequence Detail 4213 Not Applicable 
polypeptide OTTMUSP00000017024 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013448 tyrosine-protein phosphatase non-receptor type 1
References (Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:210736 Medgyesi D, et al., The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity. J Exp Med. 2014 Mar 10;211(3):427-40
All references(126)
Other
accession IDs
MGD-MRK-13674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory