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Ptpn1
Gene Detail
Symbol

Name
ID
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
MGI:97805
Synonyms
PTP1B, PTP-1B
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.99 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:167932057-167979385 bp, + strand
From VEGA annotation of GRCm38

  47329 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPN1
Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 1/2 types
Gene Tree: Ptpn1

Human
homologs
PTPN1, protein tyrosine phosphatase, non-receptor type 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5770
neXtProt AC: NX_P18031

Human Synonyms: PTP1B

Human Chr (Location): 20q13.1-q13.2; chr20:50510321-50584762 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTPN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.
 
Interactions
Ptpn1 interacts with 239 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (10)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 9
RT-PCR 1
cDNA source data(129)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptpn1 ; ZFIN ptpn1    NEW 
Molecular
reagents
All nucleic(130) cDNA(129) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015956 (Evidence)
Ensembl Gene Model ENSMUSG00000027540 (Evidence)
Entrez Gene 19246 (Evidence)
UniGene 277916
DFCI TC1572840, TC1602046, TC1630391, TC1678078, TC1772302
DoTS DT.101401137, DT.110682341, DT.536218, DT.97414531
NIA Mouse Gene Index U002857
EC 3.1.3.48
Consensus CDS Project CCDS17107.1
International Mouse Phenotyping Consortium Status Ptpn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015956 VEGA Gene Model | MGI Sequence Detail 47329 C57BL/6J ±  kb
transcript OTTMUST00000037925 VEGA | MGI Sequence Detail 4213 Not Applicable 
polypeptide OTTMUSP00000017024 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013448 tyrosine-protein phosphatase non-receptor type 1
References
(Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:219581 Dodd GT, et al., Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15;160(1-2):88-104
All references(139)
Other
accession IDs
MGD-MRK-13674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory