Ptpn1
Gene Detail

Symbol Name ID

Ptpn1 protein tyrosine phosphatase, non-receptor type 1 MGI:97805

Synonyms

PTP1B, PTP-1B

Feature Type

protein coding gene

Genetic Map

Chromosome 2

87.99 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:167932057-167979385 bp, + strand From VEGA annotation of GRCm38   47329 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 1/2 types
Gene Tree: Ptpn1

Human homologs

Human Homolog		PTPN1, protein tyrosine phosphatase, non-receptor type 1
NCBI Gene ID		5770
neXtProt AC		NX_P18031
Human Synonyms		PTP1B
Human Chr (Location)		20q13.1-q13.2; chr20:49126891-49201088 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTPN1

Alleles and phenotypes

All alleles(20) : Targeted(6) Gene trapped(14)
 

Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	actin cytoskeleton reorganization, dephosphorylation, ...
Component	cytoplasmic vesicle, cytosol, ...
Function	enzyme binding, ephrin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (10)    Tissues (5)   
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
Western blot	9
RT-PCR	1

cDNA source data(128)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(129) cDNA(128) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015956 (Evidence)
Ensembl Gene Model	ENSMUSG00000027540 (Evidence)
Entrez Gene	19246 (Evidence)
UniGene	277916
DFCI	TC1572840, TC1602046, TC1630391, TC1678078, TC1772302
DoTS	DT.101401137, DT.110682341, DT.536218, DT.97414531
NIA Mouse Gene Index	U002857
EC	3.1.3.48
Consensus CDS Project	CCDS17107.1
International Mouse Knockout Project Status	Ptpn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015956	VEGA Gene Model | MGI Sequence Detail	47329	C57BL/6J
transcript	OTTMUST00000037925	VEGA | MGI Sequence Detail	4213	Not Applicable
polypeptide	OTTMUSP00000017024	VEGA | MGI Sequence Detail	432	Not Applicable

All sequences(78) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR012265	Protein-tyrosine phosphatase, non-receptor type-1, -2
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013448	tyrosine-protein phosphatase non-receptor type 1

References

(Earliest) J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
(Latest) J:194636 Panzhinskiy E, et al., Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. Diabetologia. 2013 Mar;56(3):598-607
All references(110)

Other accession IDs

MGD-MRK-13674