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Symbol Name ID |
Ptpn1
protein tyrosine phosphatase, non-receptor type 1 MGI:97805 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Type II diabetes mellitus |
Insulin resistance |
| Disease(s) Associated with PTPN1 | ||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased susceptibility to diet-induced obesity |
abnormal homeostasis |
decreased circulating glucose level |
decreased circulating insulin level |
decreased circulating leptin level |
increased circulating leptin level |
increased core body temperature |
abnormal energy expenditure |
increased oxygen consumption |
decreased respiratory quotient |
improved glucose tolerance |
increased insulin sensitivity |
abnormal hormone level |
increased circulating adiponectin level |
decreased triglyceride level |
increased basal metabolism |
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| Availability | Mouse Genotype | |||||||||||||||||
| Ptpn1tm1Bbk/Ptpn1tm1Bbk | ||||||||||||||||||
| Ptpn1tm1Bpk/Ptpn1tm1Bpk | ||||||||||||||||||
| Ptpn1tm1Bbk/Ptpn1+ | ||||||||||||||||||
| Ptpn1tm1Bpk/Ptpn1+ | ||||||||||||||||||
| Ptpn1tm1.1Kry/Ptpn1tm1.1Kry Tg(Col1a1-cre)1Kry/0 (conditional) |
* | |||||||||||||||||
| Ptpn1tm2Bbk/Ptpn1tm2Bbk Tg(Nes-cre)1Kln/0 (conditional) |
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| Ptpn1tm2Bbk/Ptpn1+ Tg(Nes-cre)1Kln/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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