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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptpn1
protein tyrosine phosphatase, non-receptor type 1
MGI:97805
35 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptpn1Gt(OST378842)Lex/Ptpn1Gt(OST378842)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		decreased percent body fat/body weight J:185494
Ptpn1tm1.1Kry/Ptpn1tm1.1Kry
Tg(Col1a1-cre)1Kry/0
involves: 129 * C57BL/6J * FVB 		normal homeostasis/metabolism phenotype J:183709
Ptpn1tm1Bbk/Ptpn1+
involves: 129S4/SvJae * C57BL/6J 		abnormal postnatal growth/weight/body size J:63236
decreased body weight J:63236
decreased circulating insulin level J:63236
decreased circulating leptin level J:63236
Ptpn1tm1Bbk/Ptpn1tm1Bbk
involves: 129/Sv * C57BL/6 		abnormal pancreatic beta cell morphology J:87249
Ptpn1tm1Bbk/Ptpn1tm1Bbk
involves: 129S4/SvJae * C57BL/6J 		abnormal body composition J:63236
abnormal energy expenditure J:63236
abnormal fat cell morphology J:63236
abnormal fat pad morphology J:63236
abnormal food intake J:63236
abnormal postnatal growth/weight/body size J:63236
decreased body weight J:63236
decreased circulating glucose level J:63236
decreased circulating insulin level J:63236
decreased circulating leptin level J:63236
decreased epididymal fat pad weight J:63236
decreased inguinal fat pad weight J:63236
decreased interscapular fat pad weight J:63236
decreased percent body fat/body weight J:63236
decreased percent water in carcass J:63236
decreased susceptibility to diet-induced obesity J:63236
decreased white adipose tissue amount J:63236
normal endocrine/exocrine gland phenotype J:63236
improved glucose tolerance J:63236
increased basal metabolism J:63236
increased core body temperature J:63236
increased insulin sensitivity J:63236
Ptpn1tm1Bpk/Ptpn1+
involves: 129S4/SvJae * BALB/c 		decreased circulating glucose level J:53437
decreased susceptibility to diet-induced obesity J:53437
Ptpn1tm1Bpk/Ptpn1tm1Bpk
involves: 129S4/SvJae * BALB/c 		decreased circulating glucose level J:53437
decreased circulating insulin level J:53437
decreased susceptibility to diet-induced obesity J:53437
decreased triglyceride level J:53437
improved glucose tolerance J:53437
increased insulin sensitivity J:53437
Ptpn1tm2Bbk/Ptpn1+
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased body weight J:111969
decreased circulating glucose level J:111969
decreased circulating insulin level J:111969
Ptpn1tm2Bbk/Ptpn1tm2Bbk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA/2 		normal growth/size/body region phenotype J:111969
Ptpn1tm2Bbk/Ptpn1tm2Bbk
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal fat pad morphology J:111969
abnormal food intake J:111969
abnormal homeostasis J:179621
abnormal hormone level J:111969
abnormal motor capabilities/coordination/movement J:111969
decreased body weight J:111969
decreased bone mineral density J:111969
decreased circulating glucose level J:111969
decreased circulating insulin level J:111969
decreased circulating leptin level J:179621
decreased food intake J:111969
decreased respiratory quotient J:111969
decreased susceptibility to diet-induced obesity J:179621
decreased triglyceride level J:111969
improved glucose tolerance J:111969
increased circulating adiponectin level J:111969
increased circulating leptin level J:111969
increased insulin sensitivity J:111969, J:179621
increased oxygen consumption J:111969
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory