Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPP1R12A
  • Mouse genes Ppp1r12a
  • Rat genes Ppp1r12a
  • Zfish genes ppp1r12a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppp1r12a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	PPP1R12A	IDA		Human	PMID:20354225
Molecular Function	GO:0004857	enzyme inhibitor activity	PPP1R12A	IDA		Human	PMID:19245366
Molecular Function	GO:0019208	phosphatase regulator activity	PPP1R12A	IMP		Human	PMID:18477460
Molecular Function	GO:0019208	phosphatase regulator activity	PPP1R12A	IDA		Human	PMID:20354225
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppp1r12a	IDA		Rat	PMID:8543033|RGD:633336
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:P62140	Human	PMID:11067852
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:O43293	Human	PMID:15292222
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:P55160	Human	PMID:16417406
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:O18734	Human	PMID:18073109
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:P01100	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:P01100	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	PPP1R12A	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	UniProtKB:Q99LM3	Mouse	MGI:MGI:4844228|PMID:20634291
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	UniProtKB:P0C605-1	Mouse	MGI:MGI:3789432|PMID:18448676
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	UniProtKB:Q6WCQ1	Rat	PMID:15545284|RGD:8554280
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	UniProtKB:P35240	Rat	PMID:16885985|RGD:8553252
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	UniProtKB:O43293-2	Rat	PMID:17126281|RGD:10047229
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	RGD:3376|RGD:69065	Rat	PMID:20130087|RGD:9835415
Molecular Function	GO:0005515	protein binding	Ppp1r12a	IPI	RGD:69065	Rat	PMID:23219599|RGD:9835413
Molecular Function	GO:0046982	protein heterodimerization activity	ppp1r12a	IPI	ZFIN:ZDB-GENE-030131-6529	Zfish	PMID:24040418
Molecular Function	GO:0046982	protein heterodimerization activity	ppp1r12a	IPI	ZFIN:ZDB-GENE-030616-609	Zfish	PMID:24040418
Molecular Function	GO:0019901	protein kinase binding	PPP1R12A	IPI	UniProtKB:P06493	Human	PMID:18477460
Molecular Function	GO:0019901	protein kinase binding	PPP1R12A	IPI	UniProtKB:P53350	Human	PMID:18477460
Cellular Component	GO:0031672	A band	Ppp1r12a	IDA		Mouse	MGI:MGI:5688849|PMID:11067852
Cellular Component	GO:0015629	actin cytoskeleton	PPP1R12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	PPP1R12A	IDA		Human	PMID:18477460
Cellular Component	GO:0043292	contractile fiber	PPP1R12A	IDA		Human	PMID:20634291
Cellular Component	GO:0005737	cytoplasm	ppp1r12a	IDA		Zfish	PMID:29960069
Cellular Component	GO:0005829	cytosol	PPP1R12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	PPP1R12A	HDA		Human	PMID:21423176
Cellular Component	GO:0000776	kinetochore	PPP1R12A	IDA		Human	PMID:18477460
Cellular Component	GO:0005730	nucleolus	PPP1R12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PPP1R12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072357	PTW/PP1 phosphatase complex	PPP1R12A	IDA		Human	PMID:20354225
Cellular Component	GO:0030018	Z disc	Ppp1r12a	IDA		Mouse	MGI:MGI:5688849|PMID:11067852
Biological Process	GO:0051017	actin filament bundle assembly	ppp1r12a	IMP	ZFIN:ZDB-GENO-090128-3	Zfish	PMID:18776143
Biological Process	GO:0070650	actin filament bundle distribution	ppp1r12a	IMP	ZFIN:ZDB-MRPHLNO-100525-6	Zfish	PMID:25446029
Biological Process	GO:0007409	axonogenesis	ppp1r12a	IMP	ZFIN:ZDB-GENO-170420-3	Zfish	PMID:27855159
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ppp1r12a	IDA		Mouse	PMID:18524939
Biological Process	GO:0007098	centrosome cycle	PPP1R12A	IMP		Human	PMID:18477460
Biological Process	GO:0060028	convergent extension involved in axis elongation	ppp1r12a	IGI	ZFIN:ZDB-MRPHLNO-101006-1,ZFIN:ZDB-MRPHLNO-140102-1,ZFIN:ZDB-MRPHLNO-140102-2	Zfish	PMID:24040418
Biological Process	GO:0031017	exocrine pancreas development	ppp1r12a	IMP	ZFIN:ZDB-GENO-210324-1	Zfish	PMID:31705616
Biological Process	GO:0001889	liver development	ppp1r12a	IMP	ZFIN:ZDB-GENO-090128-2	Zfish	PMID:18776143
Biological Process	GO:0001889	liver development	ppp1r12a	IMP	ZFIN:ZDB-MRPHLNO-090127-2	Zfish	PMID:18776143
Biological Process	GO:0001889	liver development	ppp1r12a	IMP	ZFIN:ZDB-GENO-090128-1	Zfish	PMID:18776143
Biological Process	GO:0001889	liver development	ppp1r12a	IMP	ZFIN:ZDB-GENO-090130-1	Zfish	PMID:18776143
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	ppp1r12a	IMP	ZFIN:ZDB-MRPHLNO-100525-6	Zfish	PMID:25446029
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	ppp1r12a	IMP	ZFIN:ZDB-MRPHLNO-100525-6	Zfish	PMID:28148652
Biological Process	GO:0000278	mitotic cell cycle	PPP1R12A	IMP		Human	PMID:18477460
Biological Process	GO:0008045	motor neuron axon guidance	ppp1r12a	IMP	ZFIN:ZDB-GENO-170420-3	Zfish	PMID:27855159
Biological Process	GO:0043086	negative regulation of catalytic activity	PPP1R12A	IDA		Human	PMID:19245366
Biological Process	GO:0035508	positive regulation of myosin-light-chain-phosphatase activity	PPP1R12A	IMP		Human	PMID:25816133
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPP1R12A	IDA		Human	PMID:19245366
Biological Process	GO:0006470	protein dephosphorylation	PPP1R12A	IMP		Human	PMID:18477460
Biological Process	GO:0006470	protein dephosphorylation	Ppp1r12a	IMP		Mouse	PMID:17369396
Biological Process	GO:0030510	regulation of BMP signaling pathway	ppp1r12a	IMP	ZFIN:ZDB-GENO-210324-1	Zfish	PMID:31705616
Biological Process	GO:0030155	regulation of cell adhesion	PPP1R12A	IDA		Human	PMID:20354225
Biological Process	GO:0008360	regulation of cell shape	ppp1r12a	IMP	ZFIN:ZDB-MRPHLNO-100525-6	Zfish	PMID:25446029
Biological Process	GO:0035507	regulation of myosin-light-chain-phosphatase activity	PPP1R12A	IDA		Human	PMID:20354225
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	Ppp1r12a	IMP		Mouse	PMID:17369396

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern