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Ppp1r12a Gene Detail
Summary
  • Symbol
    Ppp1r12a
  • Name
    protein phosphatase 1, regulatory subunit 12A
  • Synonyms
    1200015F06Rik, 5730577I22Rik, D10Ertd625e, Mypt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309528
    NCBI Gene: 17931
  • Gene Overview
    MyGene.info: PPP1R12A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:108161831-108279833 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118003 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 56.33 cM, cytoband C
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M130, MBS, MYPT1
  • Links
    NCBI Gene ID: 4659
    neXtProt AC: NX_O14974
    UniProt: O14974

  • Chr Location
    12q21.2-q21.31; chr12:79773563-79935455 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before E7.5. Mice homozygous for a floxed allele activated in smooth muscle exhibit altered intestinal smooth muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17931 NCBI Gene Model | MGI Sequence Detail 118003 C57BL/6J ±  kb
    transcript NM_027892 RefSeq | MGI Sequence Detail 3403 C57BL/6  
    polypeptide Q9DBR7 UniProt | EBI | MGI Sequence Detail 1029 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      484 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013107 protein phosphatase 1 regulatory subunit 12A
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR031775 cGMP-dependent protein kinase, interacting domain
      IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
    Molecular
    Reagents
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    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1289205, MGI:1917922, MGI:1918986, MGI:2143509, MGI:2143782
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260332 Berger SL, et al., Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment. Neuron. 2018 Feb 7;97(3):555-570.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory