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Ppp1r12a Gene Detail
Summary
  • Symbol
    Ppp1r12a
  • Name
    protein phosphatase 1, regulatory (inhibitor) subunit 12A
  • Synonyms
    1200015F06Rik, 5730577I22Rik, D10Ertd625e, Mypt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309528
    NCBI Gene: 17931
  • Gene Overview
    MyGene.info: PPP1R12A
Location & Maps
more
  • Sequence Map
    Chr10:108162400-108277575 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115176 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 56.33 cM, cytoband C
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PPP1R12A, protein phosphatase 1 regulatory subunit 12A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M130, MBS, MYPT1
  • Links
    NCBI Gene ID: 4659
    neXtProt AC: NX_O14974

  • Chr Location
    12q15-q21; chr12:79773563-79935455 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    17
  • Targeted
    4
  • Genomic Mutations
    1 involving Ppp1r12a
  • Incidental Mutations
Homozygous null mice die before E7.5. Mice homozygous for a floxed allele activated in smooth muscle exhibit altered intestinal smooth muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019907 Ensembl Gene Model | MGI Sequence Detail 115176 C57BL/6J ±  kb
transcript ENSMUST00000070663 Ensembl | MGI Sequence Detail 3403 Not Applicable  
polypeptide ENSMUSP00000069257 Ensembl | MGI Sequence Detail 1004 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    484 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013107 protein phosphatase 1 regulatory subunit 12A
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR031775 cGMP-dependent protein kinase, interacting domain
    IPR017401 Protein phosphatase 1 regulatory subunit 12A/B, chordates
Molecular
Reagents
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  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 11
Other
Accession IDs
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MGI:1289205, MGI:1917922, MGI:1918986, MGI:2143509, MGI:2143782
References
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  • Summaries
    All 58
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:50092 Tate P, et al., Capturing novel mouse genes encoding chromosomal and other nuclear proteins. J Cell Sci. 1998 Sep;111(Pt 17):2575-85
  • Latest
    J:228507 Ajima R, et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory