Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCD4
  • Mouse genes Plcd4
  • Rat genes Plcd4
  • Zfish genes plcd4a,plcd4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	plcd4a	IDA		Zfish	PMID:28463110
Molecular Function	GO:0051020	GTPase binding	plcd4a	IPI	ZFIN:ZDB-GENE-060526-180	Zfish	PMID:28463110
Molecular Function	GO:0030695	GTPase regulator activity	plcd4a	IDA		Zfish	PMID:28463110
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcd4	IDA		Rat	PMID:8550568|RGD:633664
Molecular Function	GO:0005515	protein binding	PLCD4	IPI	UniProtKB:P50221	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLCD4	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	plcd4a	IPI	ZFIN:ZDB-GENE-060526-180	Zfish	PMID:28463110
Cellular Component	GO:0005829	cytosol	PLCD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PLCD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005622	intracellular anatomical structure	Plcd4	IDA		Mouse	PMID:2033248
Cellular Component	GO:0005886	plasma membrane	PLCD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	plcd4a	IDA		Zfish	PMID:28463110
Biological Process	GO:0007340	acrosome reaction	Plcd4	IMP	MGI:MGI:2155167	Mouse	PMID:11340203
Biological Process	GO:1904088	positive regulation of epiboly involved in gastrulation with mouth forming second	plcd4a	IGI	ZFIN:ZDB-GENE-060526-180	Zfish	PMID:28463110
Biological Process	GO:1901232	regulation of convergent extension involved in axis elongation	plcd4a	IGI	ZFIN:ZDB-GENE-060526-180	Zfish	PMID:28463110
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	plcd4a	IGI	ZFIN:ZDB-GENE-060526-180	Zfish	PMID:28463110

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern