About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:phosphatidylinositol phospholipase C activity
Synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
Synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
Synonym: monophosphatidylinositol phosphodiesterase activity
Synonym: phosphatidylinositol-4,5-bisphosphate hydrolysis
Synonym: phosphoinositidase C activity
Synonym: phosphoinositide phospholipase C activity
Synonym: PI-PLC activity
Synonym: triphosphoinositide phosphodiesterase activity
GO id:GO:0004435
Definition:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-alipase activity
                                                is-aphospholipase activity
                                                        is-aphospholipase C activity
                                                                is-acalcium-dependent phospholipase C activity
                                                                is-ainositol phosphosphingolipid phospholipase activity +
                                                                is-aphosphatidylcholine phospholipase C activity
                                                                is-aphosphatidylglycerol phospholipase C activity
                                                                is-aphosphatidylinositol phospholipase C activity [GO:0004435] (17 genes, 18 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-aphosphoric ester hydrolase activity
                                                is-aphosphoric diester hydrolase activity
                                                        is-aphospholipase C activity
                                                                is-acalcium-dependent phospholipase C activity
                                                                is-ainositol phosphosphingolipid phospholipase activity +
                                                                is-aphosphatidylcholine phospholipase C activity
                                                                is-aphosphatidylglycerol phospholipase C activity
                                                                is-aphosphatidylinositol phospholipase C activity [GO:0004435] (17 genes, 18 annotations)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory