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Plcd4 Gene Detail
Summary
  • Symbol
    Plcd4
  • Name
    phospholipase C, delta 4
  • Synonyms
    4921507K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107469
    NCBI Gene: 18802
  • Gene Overview
    MyGene.info: PLCD4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74541791-74565977 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C3-C5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107469
protein coding gene Chr1:74541791-74567794 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016154
protein coding gene Chr1:75151156-75176568 (+)
A/J MGP_AJ_G0016137
protein coding gene Chr1:72518079-72545287 (+)
AKR/J MGP_AKRJ_G0016094
protein coding gene Chr1:74532282-74557251 (+)
BALB/cJ MGP_BALBcJ_G0016092
protein coding gene Chr1:72585239-72611858 (+)
C3H/HeJ MGP_C3HHeJ_G0015923
protein coding gene Chr1:74869553-74895093 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016545
protein coding gene Chr1:78070479-78096063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014266
protein coding gene Chr1:68099559-68125821 (+)
CAST/EiJ MGP_CASTEiJ_G0015507
protein coding gene Chr1:74195971-74220443 (+)
CBA/J MGP_CBAJ_G0015896
protein coding gene Chr1:80606289-80630921 (+)
DBA/2J MGP_DBA2J_G0015997
protein coding gene Chr1:71851474-71876230 (+)
FVB/NJ MGP_FVBNJ_G0016000
protein coding gene Chr1:71032944-71058165 (+)
LP/J MGP_LPJ_G0016069
protein coding gene Chr1:76257181-76282585 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016020
protein coding gene Chr1:84009843-84035437 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016592
protein coding gene Chr1:74598903-74624220 (+)
PWK/PhJ MGP_PWKPhJ_G0015294
protein coding gene Chr1:71306280-71332061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015072
protein coding gene Chr1:73974857-73999565 (+)
WSB/EiJ MGP_WSBEiJ_G0015569
protein coding gene Chr1:74404728-74431616 (+)



Homology
more
  • Human Ortholog
    PLCD4, phospholipase C delta 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLCD4, phospholipase C delta 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84812
    neXtProt AC: NX_Q9BRC7
    UniProt: Q9BRC7

  • Chr Location
    2q35; chr2:218606873-218637186 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation are subfertile or sterile. Sperm from mutant males fail to initiate the acrosome reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18802 NCBI Gene Model | MGI Sequence Detail 24187 C57BL/6J ±  kb
    transcript NM_148937 RefSeq | MGI Sequence Detail 2981 Not Specified  
    polypeptide Q8K3R3 UniProt | EBI | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR028387 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR011993 PH-like domain superfamily
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
      IPR001849 Pleckstrin homology domain
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35941, MGI:1922966
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory