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Plcd4 Gene Detail
Summary
  • Symbol
    Plcd4
  • Name
    phospholipase C, delta 4
  • Synonyms
    4921507K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107469
    NCBI Gene: 18802
  • Gene Overview
    MyGene.info: PLCD4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:74542888-74567794 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24907 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C3-C5
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PLCD4, phospholipase C delta 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLCD4, phospholipase C delta 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 84812
    neXtProt AC: NX_Q9BRC7
    UniProt: Q9BRC7

  • Chr Location
    2q35; chr2:218606873-218637186 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation are subfertile or sterile. Sperm from mutant males fail to initiate the acrosome reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021578 VEGA Gene Model | MGI Sequence Detail 24907 C57BL/6J ±  kb
    transcript OTTMUST00000051213 VEGA | MGI Sequence Detail 2977 Not Applicable  
    polypeptide OTTMUSP00000024049 VEGA | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      157 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR028387 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR011993 PH-like domain superfamily
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
      IPR001849 Pleckstrin homology domain
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35941, MGI:1922966
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:142458 Yamashita M, et al., Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells. 2008 Oct;13(10):1001-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory