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Plcd4
Gene Detail
Symbol

Name
ID
Plcd4
phospholipase C, delta 4
MGI:107469
Synonyms
4921507K24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM, cytoband C3-C5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:74542888-74567794 bp, + strand
From VEGA annotation of GRCm38

  24907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88782  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
Gene Tree: Plcd4

Human
homologs
Human Homolog PLCD4, phospholipase C, delta 4
NCBI Gene ID 84812
neXtProt AC  NX_Q9BRC7
Human Chr (Location)  2q35; chr2:218607765-218637186 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Males homozygous for a targeted null mutation are subfertile or sterile. Sperm from mutant males fail to initiate the acrosome reaction.
 
Interactions
Plcd4 interacts with 326 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process acrosome reaction, intracellular signal transduction, ...
Component cell, cytoplasm, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021578 (Evidence)
Ensembl Gene ModelENSMUSG00000026173 (Evidence)
Entrez Gene18802 (Evidence)
UniGene290731
DFCITC1621276, TC1600475, TC1595020, TC1582748
NIA Mouse Gene IndexU154915
EC3.1.4.11
Consensus CDS ProjectCCDS35616.1, CCDS35617.1
International Mouse Knockout Project StatusPlcd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021578 VEGA Gene Model | MGI Sequence Detail 24907 C57BL/6J ±  kb
transcript OTTMUST00000051213 VEGA | MGI Sequence Detail 2977 Not Applicable 
polypeptide OTTMUSP00000024049 VEGA | MGI Sequence Detail 807 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(22) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012834 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
References
(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:142458 Yamashita M, et al., Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells. 2008 Oct;13(10):1001-13
All references(35)
Other
accession IDs
MGD-MRK-35941, MGI:1922966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory