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Plcd4 Gene Detail
Summary
  • Symbol
    Plcd4
  • Name
    phospholipase C, delta 4
  • Synonyms
    4921507K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107469
    NCBI Gene: 18802
  • Gene Overview
    MyGene.info: PLCD4
Location & Maps
more
  • Sequence Map
    Chr1:74542888-74567794 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24907 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C3-C5
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PLCD4, phospholipase C delta 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLCD4, phospholipase C delta 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 84812
    neXtProt AC: NX_Q9BRC7

  • Chr Location
    2q35; chr2:218607765-218637186 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Plcd4
  • Incidental Mutations
Males homozygous for a targeted null mutation are subfertile or sterile. Sperm from mutant males fail to initiate the acrosome reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021578 VEGA Gene Model | MGI Sequence Detail 24907 C57BL/6J ±  kb
transcript OTTMUST00000051213 VEGA | MGI Sequence Detail 2977 Not Applicable  
polypeptide OTTMUSP00000024049 VEGA | MGI Sequence Detail 807 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012834 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
  • EC
  • InterPro Domains
    IPR028387 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    IPR000008 C2 domain
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR011993 PH domain-like
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-35941, MGI:1922966
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
  • Latest
    J:142458 Yamashita M, et al., Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells. 2008 Oct;13(10):1001-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory