Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIDD1
  • Mouse genes Pidd1
  • Rat genes Pidd1
  • Zfish genes pidd1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pidd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	PIDD1	IDA		Human	PMID:17159900
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:P78560	Human	PMID:15073321
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:P78560	Human	PMID:16652156
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:P78560	Human	PMID:17159900
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:Q99750	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	PIDD1	IPI	UniProtKB:P78560	Human	PMID:27773430
Molecular Function	GO:0005515	protein binding	Pidd1	IPI	PR:Q61160	Mouse	PMID:16183742
Cellular Component	GO:0005737	cytoplasm	PIDD1	IDA		Human	PMID:17159900
Cellular Component	GO:0005737	cytoplasm	PIDD1	IMP		Human	PMID:21726810
Cellular Component	GO:0005737	cytoplasm	Pidd1	IDA		Mouse	PMID:16183742
Cellular Component	GO:0005829	cytosol	PIDD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:1905369	endopeptidase complex	PIDD1	IPI		Human	PMID:15073321
Cellular Component	GO:0005794	Golgi apparatus	PIDD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PIDD1	IDA		Human	PMID:17159900
Cellular Component	GO:0005634	nucleus	PIDD1	IMP		Human	PMID:21726810
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PIDD1	IDA		Human	PMID:17159900
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Pidd1	IGI	MGI:MGI:1336168	Mouse	PMID:16183742
Biological Process	GO:0006915	apoptotic process	PIDD1	IMP		Human	PMID:17159900
Biological Process	GO:0097190	apoptotic signaling pathway	Pidd1	IGI	MGI:MGI:1336168	Mouse	PMID:16183742
Biological Process	GO:0097190	apoptotic signaling pathway	Pidd1	IGI	MGI:MGI:97295	Mouse	PMID:16183742
Biological Process	GO:0097190	apoptotic signaling pathway	Pidd1	IGI	MGI:MGI:1306796	Mouse	PMID:16183742
Biological Process	GO:0006974	DNA damage response	PIDD1	IDA		Human	PMID:21726810
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	PIDD1	IMP		Human	PMID:21726810
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Pidd1	IGI	MGI:MGI:1261423	Mouse	PMID:16183742
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Pidd1	IGI	MGI:MGI:109324	Mouse	PMID:16183742
Biological Process	GO:0043066	negative regulation of apoptotic process	PIDD1	IMP		Human	PMID:21726810
Biological Process	GO:0016540	protein autoprocessing	PIDD1	IDA		Human	PMID:17159900
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	PIDD1	IMP		Human	PMID:17159900

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern