Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PARP9
  • Mouse genes Parp9
  • Rat genes Parp9
  • Zfish genes parp9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Parp9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072570	ADP-D-ribose binding	PARP9	IMP		Human	PMID:26479788
Molecular Function	GO:0019899	enzyme binding	PARP9	IPI	UniProtKB:Q460N5	Human	PMID:27796300
Molecular Function	GO:0004857	enzyme inhibitor activity	PARP9	IDA		Human	PMID:27796300
Molecular Function	GO:0042393	histone binding	PARP9	IPI	UniProtKB:Q93079	Human	PMID:26479788
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP9	IDA		Human	PMID:23230272
Molecular Function	GO:0140802	NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	PARP9	IDA		Human	PMID:28525742
Molecular Function	GO:0005515	protein binding	PARP9	IPI	UniProtKB:Q8TDB6	Human	PMID:16809771
Molecular Function	GO:0005515	protein binding	PARP9	IPI	UniProtKB:P09874	Human	PMID:23230272
Molecular Function	GO:0005515	protein binding	PARP9	IPI	UniProtKB:Q8TDB6	Human	PMID:23230272
Molecular Function	GO:0005515	protein binding	PARP9	IPI	UniProtKB:P42224,UniProtKB:Q8TDB6	Human	PMID:26479788
Molecular Function	GO:0005515	protein binding	PARP9	IPI	UniProtKB:P42224,UniProtKB:Q8TDB6,UniProtKB:Q93079	Human	PMID:26479788
Molecular Function	GO:0097677	STAT family protein binding	PARP9	IPI	UniProtKB:P42224	Human	PMID:26479788
Molecular Function	GO:0003714	transcription corepressor activity	PARP9	IMP		Human	PMID:16061477
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	PARP9	IPI	UniProtKB:Q8TDB6	Human	PMID:28525742
Cellular Component	GO:0005737	cytoplasm	PARP9	IDA		Human	PMID:16809771
Cellular Component	GO:0005737	cytoplasm	PARP9	IDA		Human	PMID:23230272
Cellular Component	GO:0005737	cytoplasm	PARP9	IDA		Human	PMID:26479788
Cellular Component	GO:0005737	cytoplasm	PARP9	IDA		Human	PMID:27796300
Cellular Component	GO:0005829	cytosol	PARP9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	PARP9	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	PARP9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PARP9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PARP9	IDA		Human	PMID:26479788
Cellular Component	GO:0005634	nucleus	PARP9	IDA		Human	PMID:16809771
Cellular Component	GO:0005634	nucleus	PARP9	IDA		Human	PMID:23230272
Cellular Component	GO:0032991	protein-containing complex	PARP9	IDA		Human	PMID:26479788
Cellular Component	GO:0090734	site of DNA damage	PARP9	IDA		Human	PMID:28525742
Biological Process	GO:0000077	DNA damage checkpoint signaling	PARP9	IMP		Human	PMID:28525742
Biological Process	GO:0006302	double-strand break repair	PARP9	IMP		Human	PMID:23230272
Biological Process	GO:0043086	negative regulation of catalytic activity	PARP9	IDA		Human	PMID:27796300
Biological Process	GO:0010629	negative regulation of gene expression	PARP9	IMP		Human	PMID:27796300
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PARP9	IMP		Human	PMID:16061477
Biological Process	GO:0035563	positive regulation of chromatin binding	PARP9	IGI	UniProtKB:Q8TDB6	Human	PMID:26479788
Biological Process	GO:0002230	positive regulation of defense response to virus by host	PARP9	IGI	UniProtKB:P42224,UniProtKB:Q8TDB6	Human	PMID:26479788
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PARP9	IGI	UniProtKB:P42224,UniProtKB:Q8TDB6	Human	PMID:26479788
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	PARP9	IGI	UniProtKB:Q8TDB6	Human	PMID:26479788
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	PARP9	IMP		Human	PMID:27796300
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	Parp9	IMP		Mouse	MGI:MGI:5905929|PMID:27796300
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PARP9	IMP		Human	PMID:27796300
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	PARP9	IMP		Human	PMID:26479788
Biological Process	GO:0060330	regulation of response to type II interferon	PARP9	IDA		Human	PMID:16809771

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern