Parp9 MGI Mouse Gene Detail - MGI:1933117 - poly (ADP-ribose) polymerase family, member 9

Symbol

Parp9
Name

poly (ADP-ribose) polymerase family, member 9
Synonyms

MGC:7868

Feature Type

protein coding gene
IDs

MGI:1933117
NCBI Gene: 80285
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:35758840-35792975 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM
Mapping Data

2 experiments

SNPs within 2kb

199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933117	protein coding gene	Chr16:35758840-35792991 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022774	protein coding gene	Chr16:34291705-34330077 (+)
A/J	MGP_AJ_G0022739	protein coding gene	Chr16:32629257-32663270 (+)
AKR/J	MGP_AKRJ_G0022712	protein coding gene	Chr16:33772173-33808025 (+)
BALB/cJ	MGP_BALBcJ_G0022741	protein coding gene	Chr16:32751791-32785033 (+)
C3H/HeJ	MGP_C3HHeJ_G0022506	protein coding gene	Chr16:33899647-33935447 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023190	protein coding gene	Chr16:35027353-35074295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020708	protein coding gene	Chr16:32984145-33020014 (+)
CAST/EiJ	MGP_CASTEiJ_G0022034	protein coding gene	Chr16:34127328-34162262 (+)
CBA/J	MGP_CBAJ_G0022476	protein coding gene	Chr16:36450265-36492409 (+)
DBA/2J	MGP_DBA2J_G0022609	protein coding gene	Chr16:32452779-32487812 (+)
FVB/NJ	MGP_FVBNJ_G0022584	protein coding gene	Chr16:32449596-32482767 (+)
LP/J	MGP_LPJ_G0022676	protein coding gene	Chr16:34021777-34059484 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022603	protein coding gene	Chr16:35722544-35759518 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023202	protein coding gene	Chr16:33827840-33866921 (+)
PWK/PhJ	MGP_PWKPhJ_G0021775	protein coding gene	Chr16:32864232-32905249 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021606	protein coding gene	Chr16:33646750-33682779 (+)
WSB/EiJ	MGP_WSBEiJ_G0022078	protein coding gene	Chr16:33755973-33794920 (+)

Human Ortholog

PARP9, poly(ADP-ribose) polymerase family member 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP9, poly(ADP-ribose) polymerase family member 9
Synonyms

ARTD9, BAL, BAL1, MGC:7868
Links

HGNC:24118

NCBI Gene ID: 83666

neXtProt AC: NX_Q8IXQ6

UniProt: Q8IXQ6
Chr Location

3q21.1; chr3:122527910-122564676 (-) GRCh38.p7

Alliance of Genome Resources

Parp9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARP9
Gene Tree

Parp9

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Gene trapped

47
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

93 strains or lines available

Mice homozygous for a null allele exhibit higher viral titers in the liver, lungs, spleen, and brains, and decreased type I IFN production in response to infection with RNA virus.

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All GO Annotations

46
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

93
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp9

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Parp9 interacts with 92 markers (Mir22, Mir34a, Mir96, ...) View All

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All Sequences

52
RefSeq

10
UniProt

4
CCDS

CCDS37326.1

Ensembl

ENSMUSG00000022906 (Evidence)
NCBI Gene

80285

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022906	Ensembl Gene Model \| MGI Sequence Detail	34136	C57BL/6J	± kb
transcript	ENSMUST00000114878	Ensembl \| MGI Sequence Detail	3548	Not Applicable
polypeptide	ENSMUSP00000110528	Ensembl \| MGI Sequence Detail	830	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012301 protein mono-ADP-ribosyltransferase PARP9

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR002589 Macro domain

IPR043472 Macro domain-like

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

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MGI:2146631

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:306337 Xing J, et al., Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Nat Commun. 2021 May 11;12(1):2681

TSS for Parp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138232	Chr16:35758840-35758859 (+)	10 bp
Tssr138233	Chr16:35758882-35758896 (+)	49 bp
Tssr138234	Chr16:35759342-35759442 (+)	552 bp
Tssr138235	Chr16:35760231-35760242 (+)	1,397 bp
Tssr138236	Chr16:35768676-35768690 (+)	9,843 bp
Tssr138237	Chr16:35777393-35777433 (+)	18,573 bp
Tssr138238	Chr16:35792555-35792589 (+)	33,732 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/07/2021 MGI 6.17