Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAPPA
  • Mouse genes Pappa
  • Rat genes Pappa
  • Zfish genes pappaa,pappab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pappa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Pappa	IDA		Mouse	PMID:11985604
Molecular Function	GO:0004222	metalloendopeptidase activity	PAPPA	EXP		Human	PMID:11513734
Molecular Function	GO:0008237	metallopeptidase activity	PAPPA	IDA		Human	PMID:10077652
Molecular Function	GO:0008233	peptidase activity	pappab	IDA		Zfish	PMID:23430244
Molecular Function	GO:0005515	protein binding	PAPPA	IPI	UniProtKB:P13727	Human	PMID:12421832
Molecular Function	GO:0005515	protein binding	PAPPA	IPI	UniProtKB:P13727	Human	PMID:7685339
Cellular Component	GO:0005576	extracellular region	PAPPA	IDA		Human	PMID:10077652
Cellular Component	GO:0005615	extracellular space	Pappa	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Pappa	IDA		Rat	PMID:15754336|RGD:1642332
Biological Process	GO:0043009	chordate embryonic development	pappab	IMP	ZFIN:ZDB-MRPHLNO-130502-1	Zfish	PMID:23430244
Biological Process	GO:0043009	chordate embryonic development	pappab	IMP	ZFIN:ZDB-MRPHLNO-130502-2	Zfish	PMID:23430244
Biological Process	GO:0007565	female pregnancy	Pappa	IEP		Rat	PMID:2423447|RGD:10412725
Biological Process	GO:0046959	habituation	pappaa	IMP	ZFIN:ZDB-GENO-150624-8	Zfish	PMID:25754827
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	pappaa	IMP	ZFIN:ZDB-GENO-190322-4	Zfish	PMID:29739870
Biological Process	GO:0030163	protein catabolic process	Pappa	IMP		Rat	PMID:15754336|RGD:1642332
Biological Process	GO:0071548	response to dexamethasone	Pappa	IMP		Rat	PMID:15754336|RGD:1642332
Biological Process	GO:0032354	response to follicle-stimulating hormone	Pappa	IEP		Rat	PMID:15087430|RGD:1642334

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern