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Pappa
Gene Detail
Symbol

Name
ID
Pappa
pregnancy-associated plasma protein A
MGI:97479
Synonyms
8430414N03Rik, IGFBP-4ase, PAG1, PAPP-A
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:65124174-65357509 bp, + strand
From VEGA annotation of GRCm38

  233336 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Pappa

Human
homologs
Human Homolog PAPPA, pregnancy-associated plasma protein A, pappalysin 1
NCBI Gene ID 5069
neXtProt AC  NX_Q13219
Human Synonyms  ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Human Chr (Location)  9q33.2; chr9:116153792-116402321 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are smaller than normal with delayed ossification, but are otherwise normal and fertile.
 
Interactions
Pappa interacts with 533 markers (Mir1a-2, Mir1b, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell differentiation, proteolysis, ...
Component extracellular region, extracellular space, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (83)    Tissues (66)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
RT-PCR 50
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(6) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000000318 (Evidence)
Ensembl Gene ModelENSMUSG00000028370 (Evidence)
Entrez Gene18491 (Evidence)
UniGene317854
DFCITC1597051, TC1598292, TC1652207
DoTSDT.101356544, DT.55130145
NIA Mouse Gene IndexU040623
EC3.4.24.79
Consensus CDS ProjectCCDS18267.1
International Mouse Knockout Project StatusPappa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000318 VEGA Gene Model | MGI Sequence Detail 233336 C57BL/6J ±  kb
transcript OTTMUST00000005757 VEGA | MGI Sequence Detail 11027 Not Applicable 
polypeptide OTTMUSP00000002730 VEGA | MGI Sequence Detail 1624 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(1419 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR006558 LamG-like jellyroll fold
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR011936 Myxococcus cysteine-rich repeat
InterPro IPR000800 Notch domain
InterPro IPR008754 Peptidase M43, pregnancy-associated plasma-A
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000012270 pappalysin-1
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:210171 Bale LK, et al., Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology. 2014 Apr;155(4):1184-7
All references(59)
Other
accession IDs
MGD-MRK-13135, MGI:1918737

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory