Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPRM1
  • Mouse genes Oprm1
  • Rat genes Oprm1
  • Zfish genes oprm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oprm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004979	beta-endorphin receptor activity	OPRM1	IMP		Human	PMID:9689128
Molecular Function	GO:0031005	filamin binding	Oprm1	IMP		Rat	PMID:19172190|RGD:7207406
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprm1	IDA		Zfish	PMID:28284867
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprm1	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprm1	IDA		Mouse	PMID:8738226
Molecular Function	GO:0004930	G protein-coupled receptor activity	Oprm1	IDA		Rat	PMID:15525342|RGD:2316635
Molecular Function	GO:0004930	G protein-coupled receptor activity	Oprm1	IMP		Rat	PMID:9224819|RGD:8656004
Molecular Function	GO:0001965	G-protein alpha-subunit binding	OPRM1	IDA		Human	PMID:20214800
Molecular Function	GO:0031681	G-protein beta-subunit binding	Oprm1	IPI	RGD:2716	Rat	PMID:19682558|RGD:5509825
Molecular Function	GO:0038047	morphine receptor activity	Oprm1	IDA		Rat	PMID:11779147|RGD:70522
Molecular Function	GO:0038047	morphine receptor activity	Oprm1	IDA		Rat	PMID:19172190|RGD:7207406
Molecular Function	GO:0038047	morphine receptor activity	Oprm1	IMP		Rat	PMID:9224819|RGD:8656004
Molecular Function	GO:0038047	morphine receptor activity	oprm1	IDA		Zfish	PMID:28284867
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:P21333	Human	PMID:14573758
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q96S59	Human	PMID:19788913
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q5T9L3	Human	PMID:20214800
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:P01210:PRO_0000008243	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:O43255	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:P35212	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q15942	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q5T9L3	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q8IUQ4	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q8TEW6	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q92905	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q96S59	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q9P0L0	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q9Y679	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:P35212	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q5T9L3	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q9H3P2	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	OPRM1	IPI	UniProtKB:Q9P0L0	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:P63092-2	Mouse	MGI:MGI:5508716|PMID:22177524
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:P04899	Mouse	MGI:MGI:6093065|PMID:18599439
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:P21729	Mouse	MGI:MGI:5295318|PMID:22000021
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:P70498	Rat	PMID:12519790|RGD:8553861
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	RGD:68438	Rat	PMID:15748148|RGD:9835006
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	RGD:2716	Rat	PMID:16967511|RGD:1601381
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:P07825	Rat	PMID:17005904|RGD:8554727
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:Q812E9	Rat	PMID:17548356|RGD:8554757
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	UniProtKB:Q6P689	Rat	PMID:20214800|RGD:7488961
Molecular Function	GO:0005515	protein binding	Oprm1	IPI	RGD:69426	Rat	PMID:21041644|RGD:9831449
Molecular Function	GO:0019904	protein domain specific binding	Oprm1	IPI	RGD:735139	Rat	PMID:20214800|RGD:7488961
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Oprm1	IMP		Rat	PMID:1846076|RGD:8656003
Cellular Component	GO:0005737	cytoplasm	Oprm1	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0030425	dendrite	Oprm1	IDA		Rat	PMID:17194545|RGD:2316621
Cellular Component	GO:0032839	dendrite cytoplasm	Oprm1	IDA		Rat	PMID:16194531|RGD:2316627
Cellular Component	GO:0032590	dendrite membrane	Oprm1	IDA		Rat	PMID:16194531|RGD:2316627
Cellular Component	GO:0005925	focal adhesion	Oprm1	IDA		Rat	PMID:17157995|RGD:1625132
Cellular Component	GO:0098982	GABA-ergic synapse	Oprm1	IDA		Mouse	PMID:31818459
Cellular Component	GO:0098982	GABA-ergic synapse	Oprm1	IMP		Mouse	PMID:31818459
Cellular Component	GO:0098982	GABA-ergic synapse	Oprm1	EXP		Mouse	PMID:31818459
Cellular Component	GO:0016020	membrane	Oprm1	IDA		Mouse	PMID:8738226
Cellular Component	GO:0016020	membrane	Oprm1	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0016020	membrane	Oprm1	IDA		Rat	PMID:17157995|RGD:1625132
Cellular Component	GO:0045121	membrane raft	Oprm1	IDA		Rat	PMID:17157995|RGD:1625132
Cellular Component	GO:0043204	perikaryon	Oprm1	IDA		Rat	PMID:17194545|RGD:2316621
Cellular Component	GO:0005886	plasma membrane	oprm1	IDA		Zfish	PMID:28284867
Cellular Component	GO:0045211	postsynaptic membrane	Oprm1	IDA		Rat	PMID:11312309|RGD:13702315
Cellular Component	GO:0042734	presynaptic membrane	Oprm1	IDA		Rat	PMID:11312309|RGD:13702315
Cellular Component	GO:0042383	sarcolemma	Oprm1	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0097444	spine apparatus	Oprm1	IDA		Rat	PMID:11312309|RGD:13702315
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	Oprm1	IEP		Rat	PMID:19298846|RGD:2316601
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Oprm1	IDA		Mouse	PMID:8738226
Biological Process	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Oprm1	IDA		Rat	PMID:8051154|RGD:8656009
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Oprm1	IDA		Mouse	PMID:8738226
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Oprm1	IDA		Rat	PMID:11779147|RGD:70522
Biological Process	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	Oprm1	IDA		Rat	PMID:17157995|RGD:1625132
Biological Process	GO:0048149	behavioral response to ethanol	OPRM1	IMP		Human	PMID:21039637
Biological Process	GO:0042755	eating behavior	Oprm1	IMP		Rat	PMID:15949635|RGD:9831409
Biological Process	GO:0044849	estrous cycle	Oprm1	IEP		Rat	PMID:21041644|RGD:9831449
Biological Process	GO:0060079	excitatory postsynaptic potential	Oprm1	IDA		Rat	PMID:18065149|RGD:2316604
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	Oprm1	IDA		Rat	PMID:19172190|RGD:7207406
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	oprm1	IDA		Zfish	PMID:28284867|ZFIN:ZDB-PUB-170313-3
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Oprm1	IDA		Rat	PMID:11779147|RGD:70522
Biological Process	GO:0007626	locomotory behavior	Oprm1	IMP	MGI:MGI:2159000	Mouse	PMID:10835636
Biological Process	GO:0007626	locomotory behavior	Oprm1	IGI	MGI:MGI:94925	Mouse	PMID:12574430
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Oprm1	IDA		Rat	PMID:15748148|RGD:9835006
Biological Process	GO:0061358	negative regulation of Wnt protein secretion	OPRM1	IMP		Human	PMID:20214800
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Oprm1	IDA		Rat	PMID:9572309|RGD:8553369
Biological Process	GO:0032100	positive regulation of appetite	Oprm1	IMP		Rat	PMID:18805404|RGD:2316603
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Oprm1	IDA		Rat	PMID:17384143|RGD:8656005
Biological Process	GO:0050769	positive regulation of neurogenesis	Oprm1	IMP		Mouse	MGI:MGI:5306306|PMID:16682964
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Oprm1	IMP		Mouse	PMID:31818459
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Oprm1	IDA		Mouse	PMID:31818459
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Oprm1	EXP		Mouse	PMID:31818459
Biological Process	GO:0080135	regulation of cellular response to stress	OPRM1	IMP		Human	PMID:21039637
Biological Process	GO:2000310	regulation of NMDA receptor activity	Oprm1	IMP		Rat	PMID:17976846|RGD:8656012
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprm1	IDA		Rat	PMID:10908631|RGD:9831416
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprm1	IDA		Rat	PMID:12710986|RGD:2316589
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprm1	IMP		Rat	PMID:16565164|RGD:9835003
Biological Process	GO:0042220	response to cocaine	Oprm1	IEP		Rat	PMID:17425581|RGD:2316610
Biological Process	GO:0045471	response to ethanol	Oprm1	IDA		Rat	PMID:17156932|RGD:8693615
Biological Process	GO:0032094	response to food	Oprm1	IEP		Rat	PMID:19301417|RGD:2316600
Biological Process	GO:0070848	response to growth factor	Oprm1	IEP		Rat	PMID:17142830|RGD:2316623
Biological Process	GO:0032496	response to lipopolysaccharide	Oprm1	IEP		Rat	PMID:17553897|RGD:2316609
Biological Process	GO:0043278	response to morphine	Oprm1	IEP		Rat	PMID:16194531|RGD:2316627
Biological Process	GO:0043278	response to morphine	Oprm1	IEP		Rat	PMID:16753266|RGD:9831397
Biological Process	GO:0009314	response to radiation	Oprm1	IEP		Rat	PMID:22337865|RGD:9831403
Biological Process	GO:0019233	sensory perception of pain	Oprm1	IMP		Mouse	MGI:MGI:85984|PMID:9037090
Biological Process	GO:0042060	wound healing	Oprm1	IEP		Rat	PMID:17605252|RGD:2316608

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern