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Oprm1 Gene Detail
Summary
  • Symbol
    Oprm1
  • Name
    opioid receptor, mu 1
  • Synonyms
    MOP-R, MOP receptor, mor, MOR-1, muOR, Oprm
  • Feature Type
    protein coding gene
  • IDs
    MGI:97441
    NCBI Gene: 18390
Location & Maps
more
  • Sequence Map
    Chr10:6758506-7038198 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      279693 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OPRM1, opioid receptor, mu 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OPRM1, opioid receptor, mu 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LMOR, MOP, MOR, MOR1, M-OR-1, OPRM
  • Links
    NCBI Gene ID: 4988
    neXtProt AC: NX_P35372

  • Chr Location
    6q24-q25; chr6:154010496-154246867 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Oprm1 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 16 alleles in 21 genetic backgrounds
    6 phenotypes from multigenic genotypes
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    1
  • Targeted
    18
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023338 VEGA Gene Model | MGI Sequence Detail 279693 C57BL/6J ±  kb
transcript OTTMUST00000056562 VEGA | MGI Sequence Detail 1695 Not Applicable  
polypeptide OTTMUSP00000027204 VEGA | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2109 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 8
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-13041
References
more
  • Summaries
    All 235
    Developmental Gene Expression 25
    Diseases 2
    Gene Ontology 12
    Phenotypes 138
  • Earliest
    J:18936 Kozak CA, et al., Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics. 1994 Jun;21(3):659-61
  • Latest
    J:226849 Ruiz M, et al., Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Hum Mol Genet. 2015 Dec 20;24(25):7159-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory