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Oprm1
Gene Detail
 Symbol
Name
ID
Oprm1
opioid receptor, mu 1
MGI:97441
Synonyms MOP-R, MOP receptor, mor, MOR-1, muOR, Oprm
Feature Type protein coding gene
Genetic Map
Chromosome 10
1.85 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr10:6758506-7038198 bp, + strand
From VEGA annotation of GRCm38

  279693 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprm1

Human
homologs
Human Homolog OPRM1, opioid receptor, mu 1
NCBI Gene ID 4988
neXtProt AC  NX_P35372
Human Synonyms  LMOR, MOP, MOR, MOR1, M-OR-1, OPRM
Human Chr (Location)  6q24-q25; chr6:154010496-154246867 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(1) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility.
 
Human Diseases Modeled Using Mouse Oprm1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Oprm1 interacts with 148 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component cytoplasm, cytosol, ...
Function beta-endorphin receptor activity, filamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (28)    Tissues (16)    Images (6)
Theiler Stages: 23, 26
Assay TypeResults
Immunohistochemistry 4
RNA in situ 24
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(8) cDNA(12)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023338 (Evidence)
Ensembl Gene ModelENSMUSG00000000766 (Evidence)
Entrez Gene18390 (Evidence)
UniGene439715
DFCITC1587554, TC1592950, TC1595160, TC1595161, TC1595162, TC1595429, TC1596826, TC1608510, TC1749717
DoTSDT.101239119, DT.101263315, DT.101263322, DT.102535588, DT.102535590, DT.110597595, DT.87039820, DT.87048857, DT.91301863, DT.91338238, DT.91338239, DT.91574934, DT.97337419, DT.97353677, DT.97353678, DT.97353679, DT.97353680, DT.97398642, DT.97398643, DT.97398644, DT.97398645, DT.97398649
NIA Mouse Gene IndexU011236
PDB4DKL
Consensus CDS ProjectCCDS56687.1
International Mouse Knockout Project StatusOprm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023338 VEGA Gene Model | MGI Sequence Detail 279693 C57BL/6J ±  kb
transcript OTTMUST00000056562 VEGA | MGI Sequence Detail 1695 Not Applicable 
polypeptide OTTMUSP00000027204 VEGA | MGI Sequence Detail 456 Not Applicable 

For the selected sequences
All sequences(250) RefSeq(7) UniProt(23)
Polymorphisms RFLP(4) : SNPs within 2kb(2109 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2113)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000105 Mu opioid receptor
InterPro IPR001418 Opioid receptor
Protein Ontology PR:000001612 mu-type opioid receptor
References (Earliest) J:18936 Kozak CA, et al., Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics. 1994 Jun;21(3):659-61
(Latest) J:208045 Koodie L, et al., Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice. Am J Pathol. 2014 Apr;184(4):1073-84
All references(233)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory