Oprm1
Gene Detail

Symbol Name ID

Oprm1 opioid receptor, mu 1 MGI:97441

Synonyms

MOP-R, MOP receptor, mor, MOR-1, muOR, Oprm

Feature Type

protein coding gene

Genetic Map

Chromosome 10

1.85 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr10:6758506-7038198 bp, + strand From VEGA annotation of GRCm38   279693 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprm1

Human homologs

Human Homolog		OPRM1, opioid receptor, mu 1
NCBI Gene ID		4988
neXtProt AC		NX_P35372
Human Synonyms		LMOR, MOP, MOR, MOR1, M-OR-1, OPRM
Human Chr (Location)		6q24-q25; chr6:154331631-154568001 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(15) Gene trapped(1)
 

Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component	dendrite, dendrite cytoplasm, ...
Function	beta-endorphin receptor activity, filamin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (28)    Tissues (16)    Images (6)
Theiler Stages: 23, 26

Assay Type	Results
Immunohistochemistry	4
RNA in situ	24

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(8) cDNA(13)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000023338 (Evidence)
Ensembl Gene Model	ENSMUSG00000000766 (Evidence)
Entrez Gene	18390 (Evidence)
UniGene	457998
DFCI	TC1587554, TC1592950, TC1595160, TC1595161, TC1595162, TC1595429, TC1596826, TC1608510, TC1749717
DoTS	DT.101239119, DT.101263315, DT.101263322, DT.102535588, DT.102535590, DT.110597595, DT.87039820, DT.87048857, DT.91301863, DT.91338238, DT.91338239, DT.91574934, DT.97337419, DT.97353677, DT.97353678, DT.97353679, DT.97353680, DT.97398642, DT.97398643, DT.97398644, DT.97398645, DT.97398649
NIA Mouse Gene Index	U011236
PDB	4DKL
Consensus CDS Project	CCDS56687.1
International Mouse Knockout Project Status	Oprm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023338	VEGA Gene Model | MGI Sequence Detail	279693	C57BL/6J
transcript	OTTMUST00000056562	VEGA | MGI Sequence Detail	1695	Not Applicable
polypeptide	OTTMUSP00000027204	VEGA | MGI Sequence Detail	456	Not Applicable

All sequences(245) RefSeq(3) UniProt(23)

Polymorphisms

RFLP(4) : SNPs(1598 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000105	Mu opioid receptor
InterPro	IPR001418	Opioid receptor
Protein Ontology	PR:000001612	mu-type opioid receptor

References

(Earliest) J:18936 Kozak CA, et al., Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics. 1994 Jun;21(3):659-61
(Latest) J:193261 Goldsmith JR, et al., Intestinal Epithelial Cell-Derived mu-Opioid Signaling Protects against Ischemia Reperfusion Injury through PI3K Signaling. Am J Pathol. 2013 Mar;182(3):776-85
All references(222)

Other accession IDs

MGD-MRK-13041