Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables G protein-coupled opioid receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and transmission of nerve impulse. Acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and locomotory behavior. Located in membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including central nervous system; early conceptus; peripheral nervous system; retina inner nuclear layer; and uterus. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug psychosis; nicotine dependence; and opiate dependence (multiple). Orthologous to human OPRM1 (opioid receptor mu 1).