Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlrp3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NLRP3
- Mouse genes Nlrp3
- Rat genes Nlrp3
- Zfish genes nlrc10,nlrc11,nlrc6,nlrc7,nlrc8,nlrc9,nlrp3,si:cabz01069012.2,si:ch211-114l13.1,si:ch211-114l13.13,si:ch211-133h13.1,si:ch211-149a19.3,si:ch211-15j1.1,si:ch211-15j1.3,si:ch211-15j1.4,si:ch211-15j1.5,si:ch211-171l17.4,si:ch211-181d7.1,si:ch211-187g4.1,si:ch211-191a16.2,si:ch211-191a16.5,si:ch211-194e1.7,si:ch211-194e1.9,si:ch211-196h16.5,si:ch211-196h24.1,si:ch211-197e7.1,si:ch211-201o1.1,si:ch211-203c5.3,si:ch211-205a14.1,si:ch211-207e19.2,si:ch211-213a13.9,si:ch211-214b16.3,si:ch211-226o13.1,si:ch211-227e10.6,si:ch211-227p7.5,si:ch211-22k7.9,si:ch211-232d10.1,si:ch211-233m11.1,si:ch211-236p5.2,si:ch211-236p5.3,si:ch211-237a4.2,si:ch211-238e22.8,si:ch211-250k18.7,si:ch211-255g12.8,si:ch211-271g18.1,si:ch211-278p9.1,si:ch211-76m11.3,si:ch211-76m11.5,si:ch211-76m11.8,si:ch73-168d20.1,si:ch73-233m11.2,si:ch73-236c18.2,si:ch73-236c18.5,si:ch73-236c18.7,si:ch73-24k9.2,si:ch73-50f9.4,si:dkey-11n14.1,si:dkey-121n8.7,si:dkey-124l13.1,si:dkey-151g22.1,si:dkey-165e24.1,si:dkey-165o8.1,si:dkey-178j11.5,si:dkey-193i10.4,si:dkey-222h21.1,si:dkey-222h21.10,si:dkey-222h21.11,si:dkey-222h21.2,si:dkey-222h21.3,si:dkey-222h21.7,si:dkey-222h21.8,si:dkey-222h21.9,si:dkey-233e3.2,si:dkey-23k10.2,si:dkey-264f17.2,si:dkey-26m3.3,si:dkey-27n6.1,si:dkey-29j8.1,si:dkey-51d8.1,si:dkey-61p9.9,si:dkey-71l4.4,si:dkeyp-100h4.1,si:dkeyp-35e5.5,si:dkeyp-4c4.1,si:dkeyp-4f2.1,si:rp71-7l19.2,si:zfos-364h11.1,zgc:110171,zgc:173709,zgc:174180,zgc:194906,zmp:0000001020
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	NLRP3	IDA		Human	PMID:35114687
Molecular Function	GO:0043531	ADP binding	NLRP3	IDA		Human	PMID:35254907
Molecular Function	GO:0005524	ATP binding	NLRP3	IDA		Human	PMID:17483456
Molecular Function	GO:0005524	ATP binding	NLRP3	IDA		Human	PMID:36442502
Molecular Function	GO:0016887	ATP hydrolysis activity	NLRP3	IDA		Human	PMID:17483456
Molecular Function	GO:0016887	ATP hydrolysis activity	NLRP3	IDA		Human	PMID:31086327
Molecular Function	GO:0016887	ATP hydrolysis activity	NLRP3	IDA		Human	PMID:31086329
Molecular Function	GO:0016887	ATP hydrolysis activity	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	NLRP3	IDA		Human	PMID:31189953
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Molecular Function	GO:0042802	identical protein binding	NLRP3	IPI	UniProtKB:Q96P20	Human	PMID:23582325
Molecular Function	GO:0042802	identical protein binding	NLRP3	IPI	UniProtKB:Q96P20	Human	PMID:24630722
Molecular Function	GO:0060090	molecular adaptor activity	NLRP3	IDA		Human	PMID:1189953
Molecular Function	GO:0140693	molecular condensate scaffold activity	NLRP3	IDA		Human	PMID:35114687
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding	NLRP3	IDA		Human	PMID:34554188
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	NLRP3	IDA		Human	PMID:30487600
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	Nlrp3	IDA		Mouse	MGI:MGI:6260219\|PMID:30487600
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:11786556
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:15020601
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:15030775
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9Y2G2	Human	PMID:15030775
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:19158675
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9HC29	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q96PP8	Human	PMID:22461501
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:P19525	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q7Z434	Human	PMID:23582325
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:P32121	Human	PMID:23809162
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9H6R0	Human	PMID:23871209
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:W6CW81	Human	PMID:24531343
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:24630722
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:O15553	Human	PMID:26347139
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q8TDX7	Human	PMID:26814970
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ES74	Human	PMID:26814970
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:28229991
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q80H93	Human	PMID:31231549
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:31421660
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:P0DTC9	Human	PMID:34341353
Molecular Function	GO:0005515	protein binding	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:34341353
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q9EPB4	Mouse	MGI:MGI:5466621\|PMID:23143333
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q9ES74	Mouse	MGI:MGI:5698271\|PMID:26642356
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q03963\|UniProtKB:Q9EPB4	Mouse	MGI:MGI:5432942\|PMID:22801494
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q03963	Mouse	MGI:MGI:5432942\|PMID:22801494
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q9ES74	Mouse	MGI:MGI:5751332\|PMID:26814970
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q8CFB4	Mouse	MGI:MGI:5319585\|PMID:22461501
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q62167	Mouse	MGI:MGI:6368386\|PMID:31511697
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q9EPB4	Mouse	MGI:MGI:5915552\|PMID:25605870
Molecular Function	GO:0005515	protein binding	Nlrp3	IPI	UniProtKB:Q64287	Mouse	MGI:MGI:5689221\|PMID:26098997
Molecular Function	GO:0043565	sequence-specific DNA binding	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Molecular Function	GO:0035591	signaling adaptor activity	NLRP3	IDA		Human	PMID:27432880
Molecular Function	GO:0035591	signaling adaptor activity	NLRP3	IDA		Human	PMID:35114687
Molecular Function	GO:0035591	signaling adaptor activity	NLRP3	IDA		Human	PMID:35254907
Molecular Function	GO:0035591	signaling adaptor activity	NLRP3	IDA		Human	PMID:35559676
Molecular Function	GO:0035591	signaling adaptor activity	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Molecular Function	GO:0035591	signaling adaptor activity	Nlrp3	IDA		Mouse	PMID:26173909
Molecular Function	GO:0140299	small molecule sensor activity	NLRP3	IDA		Human	PMID:16407889
Molecular Function	GO:0140299	small molecule sensor activity	NLRP3	IDA		Human	PMID:18403674
Molecular Function	GO:0140299	small molecule sensor activity	NLRP3	IDA		Human	PMID:18604214
Molecular Function	GO:0140299	small molecule sensor activity	Nlrp3	IDA		Mouse	MGI:MGI:7388221\|PMID:18403674
Cellular Component	GO:0061702	canonical inflammasome complex	Nlrp3	IDA		Mouse	PMID:30248149
Cellular Component	GO:0005737	cytoplasm	NLRP3	IDA		Human	PMID:34512673
Cellular Component	GO:0005737	cytoplasm	NLRP3	IDA		Human	PMID:17164409
Cellular Component	GO:0005737	cytoplasm	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Cellular Component	GO:0005829	cytosol	NLRP3	IDA		Human	PMID:11786556
Cellular Component	GO:0000139	Golgi membrane	NLRP3	IDA		Human	PMID:23229815
Cellular Component	GO:0031021	interphase microtubule organizing center	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Cellular Component	GO:0016020	membrane	NLRP3	IDA		Human	PMID:30487600
Cellular Component	GO:0016020	membrane	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Cellular Component	GO:0016020	membrane	Nlrp3	IDA		Mouse	MGI:MGI:6260219\|PMID:30487600
Cellular Component	GO:0016020	membrane	Nlrp3	IDA		Mouse	PMID:26173909
Cellular Component	GO:0005815	microtubule organizing center	NLRP3	IDA		Human	PMID:28656979
Cellular Component	GO:0005815	microtubule organizing center	Nlrp3	IDA		Mouse	MGI:MGI:5921465\|PMID:28656979
Cellular Component	GO:0005739	mitochondrion	NLRP3	IDA		Human	PMID:23582325
Cellular Component	GO:0005739	mitochondrion	Nlrp3	IDA		Mouse	MGI:MGI:5492224\|PMID:23582325
Cellular Component	GO:0072559	NLRP3 inflammasome complex	NLRP3	IPI		Human	PMID:29255148
Cellular Component	GO:0072559	NLRP3 inflammasome complex	NLRP3	IDA		Human	PMID:15030775
Cellular Component	GO:0072559	NLRP3 inflammasome complex	NLRP3	IDA		Human	PMID:36442502
Cellular Component	GO:0072559	NLRP3 inflammasome complex	Nlrp3	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Cellular Component	GO:0072559	NLRP3 inflammasome complex	nlrp3	IDA		Zfish	PMID:31852739
Cellular Component	GO:0005634	nucleus	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Nlrp3	IMP	MGI:MGI:3686871	Mouse	PMID:17008311
Biological Process	GO:0002526	acute inflammatory response	Nlrp3	IDA		Mouse	PMID:30248149
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NLRP3	IMP		Human	PMID:12483741
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NLRP3	IDA		Human	PMID:28847925
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nlrp3	IDA		Mouse	MGI:MGI:6095076\|PMID:28847925
Biological Process	GO:0071224	cellular response to peptidoglycan	Nlrp3	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0098586	cellular response to virus	NLRP3	IDA		Human	PMID:33231615
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nlrp3	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0051607	defense response to virus	Nlrp3	IMP	MGI:MGI:3686871	Mouse	PMID:17008311
Biological Process	GO:0009595	detection of biotic stimulus	NLRP3	IDA		Human	PMID:18604214
Biological Process	GO:0009595	detection of biotic stimulus	Nlrp3	IDA		Mouse	MGI:MGI:7388221\|PMID:18403674
Biological Process	GO:0006954	inflammatory response	NLRP3	IMP		Human	PMID:12093792
Biological Process	GO:0006954	inflammatory response	NLRP3	IDA		Human	PMID:16407889
Biological Process	GO:0006954	inflammatory response	NLRP3	IDA		Human	PMID:17483456
Biological Process	GO:0006954	inflammatory response	NLRP3	IDA		Human	PMID:18403674
Biological Process	GO:0006954	inflammatory response	NLRP3	IDA		Human	PMID:18604214
Biological Process	GO:0006954	inflammatory response	NLRP3	IMP		Human	PMID:28847925
Biological Process	GO:0006954	inflammatory response	Nlrp3	IDA		Mouse	MGI:MGI:6095076\|PMID:28847925
Biological Process	GO:0032611	interleukin-1 beta production	Nlrp3	IDA		Mouse	PMID:30248149
Biological Process	GO:0032611	interleukin-1 beta production	Nlrp3	IGI	MGI:MGI:107700	Mouse	PMID:22002608
Biological Process	GO:0032611	interleukin-1 beta production	Nlrp3	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0032611	interleukin-1 beta production	Nlrp3	IMP	MGI:MGI:5465108	Mouse	PMID:22753929
Biological Process	GO:0032612	interleukin-1 production	Nlrp3	IMP	MGI:MGI:3686871	Mouse	PMID:17008311
Biological Process	GO:0032621	interleukin-18 production	Nlrp3	IMP	MGI:MGI:3686871	Mouse	PMID:17008311
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Nlrp3	IEP		Rat	PMID:27939985\|RGD:15036816
Biological Process	GO:0010934	macrophage cytokine production	Nlrp3	IDA		Mouse	PMID:30248149
Biological Process	GO:0010934	macrophage cytokine production	Nlrp3	IMP	MGI:MGI:5465108	Mouse	PMID:22753929
Biological Process	GO:0002674	negative regulation of acute inflammatory response	NLRP3	IMP		Human	PMID:11687797
Biological Process	GO:0050728	negative regulation of inflammatory response	NLRP3	IMP		Human	PMID:12483741
Biological Process	GO:0050728	negative regulation of inflammatory response	NLRP3	IMP		Human	PMID:16531551
Biological Process	GO:0050728	negative regulation of inflammatory response	NLRP3	IMP		Human	PMID:17178985
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	NLRP3	IMP		Human	PMID:12483741
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	NLRP3	IDA		Human	PMID:14662828
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	NLRP3	IDA		Human	PMID:14662828
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:17483456
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:23582325
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:25686105
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:27043286
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:27432880
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:28465465
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:28656979
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:28943315
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:30487600
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:31189953
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:33231615
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:34554188
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:34615873
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:35114687
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:35254907
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:35559676
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	NLRP3	IDA		Human	PMID:36442502
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:5492224\|PMID:23582325
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:5913002\|PMID:28716882
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:6106673\|PMID:28943315
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:5921465\|PMID:28656979
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:6260219\|PMID:30487600
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:5792478\|PMID:27043286
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:6859739\|PMID:28465465
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	MGI:MGI:6787653\|PMID:34615873
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IDA		Mouse	PMID:26173909
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	Nlrp3	IMP	MGI:MGI:5465108	Mouse	PMID:22753929
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	nlrp3	IDA		Zfish	PMID:31852739
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	NLRP3	IDA		Human	PMID:15030775
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Nlrp3	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:25686105
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:31086327
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:31086329
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:31189953
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:35114687
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:35254907
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP3	IDA		Human	PMID:35559676
Biological Process	GO:0050729	positive regulation of inflammatory response	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:15030775
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:16407889
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:17483456
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:18403674
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:18604214
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:23582325
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:25686105
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IMP		Human	PMID:28847925
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:30487600
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:31086327
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:31086329
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP3	IDA		Human	PMID:31189953
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IDA		Mouse	MGI:MGI:6095076\|PMID:28847925
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IDA		Mouse	MGI:MGI:6112461\|PMID:29255148
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IDA		Mouse	MGI:MGI:5492224\|PMID:23582325
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IDA		Mouse	MGI:MGI:6260219\|PMID:30487600
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IGI	MGI:MGI:2686159	Mouse	PMID:23997220
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IGI	MGI:MGI:107700	Mouse	PMID:22002608
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp3	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0032754	positive regulation of interleukin-5 production	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NLRP3	IDA		Human	PMID:19158675
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NLRP3	IPI	UniProtKB:Q9ULZ3	Human	PMID:15817483
Biological Process	GO:0140639	positive regulation of pyroptosis	nlrp3	IDA		Zfish	PMID:31852739
Biological Process	GO:2000321	positive regulation of T-helper 17 cell differentiation	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nlrp3	IDA		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0002830	positive regulation of type 2 immune response	Nlrp3	IMP		Mouse	MGI:MGI:5689221\|PMID:26098997
Biological Process	GO:0051260	protein homooligomerization	NLRP3	IDA		Human	PMID:35114687
Biological Process	GO:0051260	protein homooligomerization	NLRP3	IDA		Human	PMID:35254907
Biological Process	GO:0051260	protein homooligomerization	NLRP3	IDA		Human	PMID:35559676
Biological Process	GO:0051260	protein homooligomerization	NLRP3	IDA		Human	PMID:36442502
Biological Process	GO:0051260	protein homooligomerization	Nlrp3	IDA		Mouse	MGI:MGI:6844859\|PMID:34861190
Biological Process	GO:0051604	protein maturation	NLRP3	IDA		Human	PMID:31189953
Biological Process	GO:0070269	pyroptosis	nlrp3	IDA		Zfish	PMID:31852739
Biological Process	GO:0050727	regulation of inflammatory response	Nlrp3	IMP	MGI:MGI:3686871	Mouse	PMID:22297845
Biological Process	GO:0045471	response to ethanol	Nlrp3	IEP		Rat	PMID:27939985\|RGD:15036816
Biological Process	GO:0014070	response to organic cyclic compound	Nlrp3	IEP		Rat	PMID:27939985\|RGD:15036816

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.