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Gene Ontology Browser
Term Detail
GO term:NLRP3 inflammasome complex
Synonym: NALP3 inflammasome complex
GO id:GO:0072559
Definition:A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
Number of paths to term: 17

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-acytosol
                                                                        part-ofcytosolic part
                                                                                is-ainflammasome complex
                                                                                        is-aAIM2 inflammasome complex
                                                                                        is-aIPAF inflammasome complex
                                                                                        is-aNLRP1 inflammasome complex
                                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-acytosolic part
                                                                        is-ainflammasome complex
                                                                                is-aAIM2 inflammasome complex
                                                                                is-aIPAF inflammasome complex
                                                                                is-aNLRP1 inflammasome complex
                                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-ainflammasome complex
                                                                                is-aAIM2 inflammasome complex
                                                                                is-aIPAF inflammasome complex
                                                                                is-aNLRP1 inflammasome complex
                                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-acytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-ainflammasome complex
                                                                                is-aAIM2 inflammasome complex
                                                                                is-aIPAF inflammasome complex
                                                                                is-aNLRP1 inflammasome complex
                                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-acytosolic part
                                                        is-ainflammasome complex
                                                                is-aAIM2 inflammasome complex
                                                                is-aIPAF inflammasome complex
                                                                is-aNLRP1 inflammasome complex
                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-ainflammasome complex
                                                                                is-aAIM2 inflammasome complex
                                                                                is-aIPAF inflammasome complex
                                                                                is-aNLRP1 inflammasome complex
                                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-acytosolic part
                                                        is-ainflammasome complex
                                                                is-aAIM2 inflammasome complex
                                                                is-aIPAF inflammasome complex
                                                                is-aNLRP1 inflammasome complex
                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-ainflammasome complex
                                                                        is-aAIM2 inflammasome complex
                                                                        is-aIPAF inflammasome complex
                                                                        is-aNLRP1 inflammasome complex
                                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-acytosolic part
                                                        is-ainflammasome complex
                                                                is-aAIM2 inflammasome complex
                                                                is-aIPAF inflammasome complex
                                                                is-aNLRP1 inflammasome complex
                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-acytosol
                                                part-ofcytosolic part
                                                        is-ainflammasome complex
                                                                is-aAIM2 inflammasome complex
                                                                is-aIPAF inflammasome complex
                                                                is-aNLRP1 inflammasome complex
                                                                is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-acytosolic part
                                                is-ainflammasome complex
                                                        is-aAIM2 inflammasome complex
                                                        is-aIPAF inflammasome complex
                                                        is-aNLRP1 inflammasome complex
                                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


obsolete Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-ainflammasome complex
                                        is-aAIM2 inflammasome complex
                                        is-aIPAF inflammasome complex
                                        is-aNLRP1 inflammasome complex
                                        is-aNLRP3 inflammasome complex [GO:0072559] (4 genes, 5 annotations)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory