Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MECOM
  • Mouse genes Mecom
  • Rat genes Mecom
  • Zfish genes mecom
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mecom

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Mecom	IDA		Mouse	MGI:MGI:4418648|PMID:2106070
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mecom	IMP		Mouse	MGI:MGI:3581997|PMID:15889140
Molecular Function	GO:0003700	DNA-binding transcription factor activity	MECOM	IDA		Human	PMID:19767769
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mecom	IDA		Mouse	MGI:MGI:4418594|PMID:19767769
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mecom	IDA		Mouse	MGI:MGI:3581997|PMID:15889140
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Mecom	IDA		Mouse	MGI:MGI:6274969|PMID:22939622
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:P45983	Human	PMID:10856240
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:P49186	Human	PMID:10856240
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:P56546	Human	PMID:11328817
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q13363	Human	PMID:11568182
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q92793	Human	PMID:11568182
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q92831	Human	PMID:11568182
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:P56546	Human	PMID:17635584
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q9UBK9	Human	PMID:17635584
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q96EB6	Human	PMID:21555002
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:P01100	Human	PMID:22308434
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q5R372-2	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	MECOM	IPI	UniProtKB:Q09028	Human	PMID:30462309
Molecular Function	GO:0005515	protein binding	Mecom	IPI	UniProtKB:O54864	Mouse	MGI:MGI:3804770|PMID:18619962
Molecular Function	GO:0005515	protein binding	Mecom	IPI	UniProtKB:P01101	Mouse	MGI:MGI:5316169|PMID:22308434
Molecular Function	GO:0005515	protein binding	Mecom	IPI	UniProtKB:Q9Z2D8-1	Mouse	MGI:MGI:3805072|PMID:18500823
Molecular Function	GO:0005515	protein binding	Mecom	IPI	UniProtKB:Q9Z2D8	Mouse	MGI:MGI:3805072|PMID:18500823
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mecom	IDA		Mouse	PMID:15889140
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Mecom	IMP		Mouse	MGI:MGI:5825440|PMID:8557637
Cellular Component	GO:0016607	nuclear speck	MECOM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	MECOM	IDA		Human	PMID:11568182
Cellular Component	GO:0005634	nucleus	MECOM	IDA		Human	PMID:15897867
Cellular Component	GO:0005634	nucleus	Mecom	IDA		Mouse	MGI:MGI:3804770|PMID:18619962
Cellular Component	GO:0005634	nucleus	Mecom	IDA		Mouse	MGI:MGI:4418648|PMID:2106070
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	mecom	IMP	ZFIN:ZDB-MRPHLNO-130225-2	Zfish	PMID:23109401
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	mecom	IGI	ZFIN:ZDB-MRPHLNO-130225-2,ZFIN:ZDB-MRPHLNO-130225-4	Zfish	PMID:23109401
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	mecom	IGI	ZFIN:ZDB-MRPHLNO-050221-1,ZFIN:ZDB-MRPHLNO-130225-2	Zfish	PMID:23109401
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	mecom	IGI	ZFIN:ZDB-MRPHLNO-050221-1,ZFIN:ZDB-MRPHLNO-130225-2	Zfish	PMID:23109401
Biological Process	GO:0098508	endothelial to hematopoietic transition	mecom	IMP	ZFIN:ZDB-MRPHLNO-161213-1,ZFIN:ZDB-MRPHLNO-161213-2	Zfish	PMID:27638855
Biological Process	GO:0030900	forebrain development	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Mecom	IMP		Mouse	MGI:MGI:3581997|PMID:15889140
Biological Process	GO:0070828	heterochromatin organization	Mecom	IMP		Mouse	MGI:MGI:6274969|PMID:22939622
Biological Process	GO:0001701	in utero embryonic development	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0006954	inflammatory response	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0098727	maintenance of cell number	Mecom	IGI	MGI:MGI:1917923	Mouse	PMID:24703692
Biological Process	GO:1903251	multi-ciliated epithelial cell differentiation	mecom	IMP	ZFIN:ZDB-MRPHLNO-150410-1,ZFIN:ZDB-MRPHLNO-150424-1	Zfish	PMID:24309209
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	MECOM	IDA		Human	PMID:10856240
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	MECOM	IDA		Human	PMID:11568182
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Mecom	IDA		Mouse	MGI:MGI:3804770|PMID:18619962
Biological Process	GO:0046329	negative regulation of JNK cascade	MECOM	IMP		Human	PMID:10856240
Biological Process	GO:0043069	negative regulation of programmed cell death	MECOM	IMP		Human	PMID:10856240
Biological Process	GO:0001780	neutrophil homeostasis	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0060039	pericardium development	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Mecom	IMP		Mouse	PMID:24703692
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MECOM	IDA		Human	PMID:11568182
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MECOM	IDA		Human	PMID:19767769
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mecom	IMP		Mouse	MGI:MGI:3581997|PMID:15889140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mecom	IDA		Mouse	PMID:15889140
Biological Process	GO:0009791	post-embryonic development	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0035777	pronephric distal tubule development	mecom	IGI	ZFIN:ZDB-GENE-990726-27	Zfish	PMID:30575756
Biological Process	GO:0035777	pronephric distal tubule development	mecom	IMP	ZFIN:ZDB-MRPHLNO-190523-1,ZFIN:ZDB-MRPHLNO-190523-2	Zfish	PMID:30575756
Biological Process	GO:0035777	pronephric distal tubule development	mecom	IGI	ZFIN:ZDB-GENE-050208-123	Zfish	PMID:30575756
Biological Process	GO:0035777	pronephric distal tubule development	mecom	IMP	ZFIN:ZDB-MRPHLNO-150410-1,ZFIN:ZDB-MRPHLNO-150424-1	Zfish	PMID:24309209
Biological Process	GO:0035776	pronephric proximal tubule development	mecom	IMP	ZFIN:ZDB-MRPHLNO-150410-1,ZFIN:ZDB-MRPHLNO-150424-1	Zfish	PMID:24309209
Biological Process	GO:0048793	pronephros development	mecom	IMP	ZFIN:ZDB-MRPHLNO-150410-1,ZFIN:ZDB-MRPHLNO-150424-1	Zfish	PMID:24309209
Biological Process	GO:0072196	proximal/distal pattern formation involved in pronephric nephron development	mecom	IMP	ZFIN:ZDB-MRPHLNO-150410-1,ZFIN:ZDB-MRPHLNO-150424-1	Zfish	PMID:24309209
Biological Process	GO:0051726	regulation of cell cycle	MECOM	IDA		Human	PMID:11568182
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	Mecom	IMP	MGI:MGI:1857461	Mouse	PMID:15889140
Biological Process	GO:0008593	regulation of Notch signaling pathway	mecom	IMP	ZFIN:ZDB-MRPHLNO-161213-1,ZFIN:ZDB-MRPHLNO-161213-2	Zfish	PMID:27638855
Biological Process	GO:0009617	response to bacterium	Mecom	IMP	MGI:MGI:2158381	Mouse	PMID:17029558
Biological Process	GO:0072197	ureter morphogenesis	Mecom	IGI	MGI:MGI:99783	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Mecom	IGI	MGI:MGI:95663	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Mecom	IGI	MGI:MGI:97486	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Mecom	IGI	MGI:MGI:95388	Mouse	PMID:21731775

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern