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Mecom
Gene Detail
Symbol

Name
ID
Mecom
MDS1 and EVI1 complex locus
MGI:95457
Synonyms
D630039M04Rik, Evi1, Evi-1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
12.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr3:29951296-30548008 bp, - strand
From VEGA annotation of GRCm38

  596713 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21086  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MECOM
Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Mecom

Human
homologs
MECOM, MDS1 and EVI1 complex locus
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2122
neXtProt AC: NX_Q03112, NX_Q13465

Human Synonyms: AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3

Human Chr (Location): 3q26.2; chr3:169083499-169663786 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.
 
Human Diseases Modeled in Mice Using Mecom (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Mecom interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (324)    Tissues (200)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 310
Northern blot 3
RT-PCR 11
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MECOM    NEW 
Molecular
reagents
All nucleic(33) Genomic(7) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000038143 (Evidence)
Ensembl Gene Model ENSMUSG00000027684 (Evidence)
Entrez Gene 14013 (Evidence)
DFCI TC1584289, TC1587590, TC1590789, TC1596919, TC1651101, TC1680747
DoTS DT.101369632, DT.101369633, DT.103571061, DT.87038324, DT.94213381, DT.94275571, DT.97357747
NIA Mouse Gene Index U023905
Consensus CDS Project CCDS17281.2
International Mouse Phenotyping Consortium Status Mecom
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038143 VEGA Gene Model | MGI Sequence Detail 596713 C57BL/6J ±  kb
transcript OTTMUST00000098236 VEGA | MGI Sequence Detail 5066 Not Applicable 
polypeptide OTTMUSP00000055159 VEGA | MGI Sequence Detail 1051 Not Applicable 

For the selected sequences
All sequences(133) RefSeq(30) UniProt(16)
Polymorphisms
RFLP(9) : SNPs within 2kb(4093 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026710 MDS1-EVI1 complex locus protein MDS1
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000035849 MDS1 and EVI1 complex locus protein
References
(Earliest) J:6439 Chattopadhyay SK, et al., Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8
(Latest) J:216528 Sato T, et al., Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Oncogene. 2014 Oct 16;33(42):5028-38
All references(104)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory