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Mecom Gene Detail
Summary
  • Symbol
    Mecom
  • Name
    MDS1 and EVI1 complex locus
  • Synonyms
    D630039M04Rik, Evi1, Evi-1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95457
    NCBI Gene: 14013
  • Gene Overview
    MyGene.info: MECOM
Location & Maps
more
  • Sequence Map
    Chr3:29951296-30548008 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      596713 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 12.66 cM
  • Mapping Data
    35 experiments
Homology
more
  • Human Ortholog
    MECOM, MDS1 and EVI1 complex locus
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MECOM, MDS1 and EVI1 complex locus
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2
  • Links
    NCBI Gene ID: 2122
    neXtProt AC: NX_Q03112, NX_Q13465

  • Chr Location
    3q26.2; chr3:169083499-169663786 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mecom mouse models; 1 with human MECOM associations

Human Disease Mouse Models
       Otitis Media, Susceptibility to   OMIM: 166760 View 1 model
       Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2; RUSAT2   OMIM: 616738
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 8 alleles in 13 genetic backgrounds
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Mecom
  • Incidental Mutations
Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038143 VEGA Gene Model | MGI Sequence Detail 596713 C57BL/6J ±  kb
transcript OTTMUST00000098236 VEGA | MGI Sequence Detail 5066 Not Applicable  
polypeptide OTTMUSP00000055159 VEGA | MGI Sequence Detail 1051 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4072 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    Genomic 7
    cDNA 21
    Primer pair 3
    Other 6

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042
References
more
  • Summaries
    All 106
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:6439 Chattopadhyay SK, et al., Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8
  • Latest
    J:229157 Hood D, et al., A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse. Dis Model Mech. 2016 Jan 1;9(1):69-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory