Mecom
Gene Detail

Symbol Name ID

Mecom MDS1 and EVI1 complex locus MGI:95457

Synonyms

D630039M04Rik, Evi1, Evi-1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

12.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr3:29951299-30548008 bp, - strand From VEGA annotation of GRCm38   596710 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21086  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Mecom

Human homologs

Human Homolog		MECOM, MDS1 and EVI1 complex locus
NCBI Gene ID		2122
neXtProt AC		NX_Q03112, NX_Q13465
Human Synonyms		AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3
Human Chr (Location)		3q26.2; chr3:168801287-169381563 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(1) Chemically induced(1)
 

Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.

 
Human Diseases Modeled Using Mouse Mecom (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	apoptotic process, cell differentiation, ...
Component	histone deacetylase complex, nuclear speck, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (295)    Tissues (170)    Images (37)
Theiler Stages: 13, 15, 17, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	281
Northern blot	3
RT-PCR	11

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(7) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000038143 (Evidence)
Ensembl Gene Model	ENSMUSG00000027684 (Evidence)
Entrez Gene	14013 (Evidence)
DFCI	TC1584289, TC1587590, TC1590789, TC1596919, TC1651101, TC1680747
DoTS	DT.101369632, DT.101369633, DT.103571061, DT.87038324, DT.94213381, DT.94275571, DT.97357747
NIA Mouse Gene Index	U023905
Consensus CDS Project	CCDS17281.2
International Mouse Knockout Project Status	Mecom

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038143	VEGA Gene Model | MGI Sequence Detail	596710	C57BL/6J
transcript	OTTMUST00000098236	VEGA | MGI Sequence Detail	5066	Not Applicable
polypeptide	OTTMUSP00000055159	VEGA | MGI Sequence Detail	1051	Not Applicable

All sequences(106) RefSeq(4) UniProt(17)

Polymorphisms

RFLP(9) : SNPs(278 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026710	MDS1-EVI1 complex locus protein MDS1
InterPro	IPR001214	SET domain
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000035849	MDS1 and EVI1 complex locus protein

References

(Earliest) J:6439 Chattopadhyay SK, et al., Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8
(Latest) J:188875 Xu X, et al., EVI1 acts as an inducible negative-feedback regulator of NF-kappaB by inhibiting p65 acetylation. J Immunol. 2012 Jun 15;188(12):6371-80
All references(99)

Other accession IDs

MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042