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Mecom
Gene Detail
 Symbol
Name
ID
Mecom
MDS1 and EVI1 complex locus
MGI:95457
Synonyms D630039M04Rik, Evi1, Evi-1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1
Feature Type protein coding gene
Genetic Map
Chromosome 3
12.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr3:29951299-30548008 bp, - strand
From VEGA annotation of GRCm38

  596710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21086  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Mecom

Human
homologs
Human Homolog MECOM, MDS1 and EVI1 complex locus
NCBI Gene ID 2122
neXtProt AC  NX_Q03112, NX_Q13465
Human Synonyms  AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3
Human Chr (Location)  3q26.2; chr3:169083499-169663775 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.
 
Human Diseases Modeled Using Mouse Mecom (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Mecom interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, ...
Component histone deacetylase complex, nuclear speck, ...
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (324)    Tissues (200)    Images (38)
Theiler Stages: 13, 15, 17, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 310
Northern blot 3
RT-PCR 11
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(7) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000038143 (Evidence)
Ensembl Gene ModelENSMUSG00000027684 (Evidence)
Entrez Gene14013 (Evidence)
DFCITC1584289, TC1587590, TC1590789, TC1596919, TC1651101, TC1680747
DoTSDT.101369632, DT.101369633, DT.103571061, DT.87038324, DT.94213381, DT.94275571, DT.97357747
NIA Mouse Gene IndexU023905
Consensus CDS ProjectCCDS17281.2
International Mouse Knockout Project StatusMecom
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038143 VEGA Gene Model | MGI Sequence Detail 596710 C57BL/6J ±  kb
transcript OTTMUST00000098236 VEGA | MGI Sequence Detail 5066 Not Applicable 
polypeptide OTTMUSP00000055159 VEGA | MGI Sequence Detail 1051 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(26) UniProt(16)
Polymorphisms RFLP(9) : SNPs within 2kb(4093 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026710 MDS1-EVI1 complex locus protein MDS1
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000035849 MDS1 and EVI1 complex locus protein
References (Earliest) J:6439 Chattopadhyay SK, et al., Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8
(Latest) J:207915 Juneja SC, et al., Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone. 2014 Mar;60:148-61
All references(102)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory