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Phenotypes Associated with This Genotype
Genotype
MGI:6102908
Allelic
Composition		 MecomJbo/Mecom+
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MecomJbo mutation (2 available); any Mecom mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:250208 )
N
• mice exhibit normal inner ear morphology
middle ear polyps ( J:250208 )
• edematous polyps projecting into the middle ear cavity
impaired hearing ( J:250208 )
• poor performance to the click-box
increased susceptibility to otitis media ( J:250208 )
• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological
abnormal pinna reflex ( J:250208 )
• poor performance to the click-box

homeostasis/metabolism

immune system
increased susceptibility to otitis media ( J:250208 )
• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 J:250208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory