Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3K9 methyltransferase activity. Involved in hematopoietic stem cell proliferation; heterochromatin organization; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of brown fat cell differentiation; and ureter morphogenesis. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; respiratory system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus).