Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LHX1
  • Mouse genes Lhx1
  • Rat genes Lhx1
  • Zfish genes lhx1a,lhx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lhx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Lhx1	IDA		Mouse	PMID:26494787
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Lhx1	IMP		Mouse	MGI:MGI:4849611|PMID:20711475
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Lhx1	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Lhx1	IGI	UniProtKB:P61375	Mouse	MGI:MGI:3695495|PMID:17166926
Molecular Function	GO:0005515	protein binding	LHX1	IPI	UniProtKB:Q53TS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX1	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX1	IPI	UniProtKB:Q86U70-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX1	IPI	UniProtKB:Q9BWG6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Lhx1	IPI	UniProtKB:P70662	Mouse	MGI:MGI:3700452|PMID:9468533
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	LHX1	IDA		Human	PMID:28473536
Cellular Component	GO:0005622	intracellular anatomical structure	Lhx1	IDA		Mouse	PMID:10482234
Cellular Component	GO:0005634	nucleus	Lhx1	IDA		Mouse	MGI:MGI:3772525|PMID:18094249
Cellular Component	GO:0005634	nucleus	Lhx1	IDA		Mouse	MGI:MGI:3614366|PMID:8793615
Cellular Component	GO:0005634	nucleus	Lhx1	IDA		Mouse	MGI:MGI:1353814|PMID:10741426
Cellular Component	GO:0005634	nucleus	Lhx1	IDA		Mouse	PMID:18076286
Cellular Component	GO:0005634	nucleus	Lhx1	IDA		Rat	PMID:8793615|RGD:8553652
Cellular Component	GO:0032991	protein-containing complex	Lhx1	IDA		Mouse	MGI:MGI:3578570|PMID:15857913
Cellular Component	GO:0005667	transcription regulator complex	Lhx1	IDA		Mouse	PMID:26494787
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Lhx1	IMP	MGI:MGI:2385716,MGI:MGI:2675121	Mouse	PMID:15930111
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Lhx1	IGI	MGI:MGI:1347476	Mouse	PMID:10498685
Biological Process	GO:0009653	anatomical structure morphogenesis	Lhx1	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0009653	anatomical structure morphogenesis	Lhx1	IMP	MGI:MGI:2385716,MGI:MGI:2675121	Mouse	PMID:15930111
Biological Process	GO:0009653	anatomical structure morphogenesis	Lhx1	IMP		Mouse	PMID:10328927
Biological Process	GO:0009948	anterior/posterior axis specification	Lhx1	IGI	MGI:MGI:2443342	Mouse	PMID:10529425
Biological Process	GO:0009952	anterior/posterior pattern specification	Lhx1	IGI	MGI:MGI:1347476	Mouse	PMID:10498685
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0030154	cell differentiation	Lhx1	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0007267	cell-cell signaling	Lhx1	IGI	MGI:MGI:107792	Mouse	PMID:17664423
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Lhx1	IGI	MGI:MGI:107792	Mouse	PMID:17664423
Biological Process	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	Lhx1	IGI	MGI:MGI:107792	Mouse	PMID:17664423
Biological Process	GO:0021549	cerebellum development	Lhx1	IGI	MGI:MGI:107792	Mouse	PMID:17664423
Biological Process	GO:0060067	cervix development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0072049	comma-shaped body morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lhx1	IGI	MGI:MGI:1347476	Mouse	PMID:10498685
Biological Process	GO:0001705	ectoderm formation	Lhx1	IGI	MGI:MGI:1347476	Mouse	PMID:10498685
Biological Process	GO:0009880	embryonic pattern specification	Lhx1	IGI	MGI:MGI:2443342	Mouse	PMID:10529425
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	Lhx1	IMP		Mouse	MGI:MGI:3772525|PMID:18094249
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0007492	endoderm development	Lhx1	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0001706	endoderm formation	Lhx1	IMP	MGI:MGI:1857848	Mouse	PMID:15355796
Biological Process	GO:0060429	epithelium development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0021871	forebrain regionalization	Lhx1	IGI	MGI:MGI:2443342	Mouse	PMID:10529425
Biological Process	GO:0001702	gastrulation with mouth forming second	Lhx1	IMP	MGI:MGI:1857848	Mouse	PMID:15355796
Biological Process	GO:0060322	head development	Lhx1	IGI	UniProtKB:Q9D032	Mouse	MGI:MGI:3578570|PMID:15857913
Biological Process	GO:0060322	head development	Lhx1	IGI	MGI:MGI:2443342	Mouse	PMID:10529425
Biological Process	GO:0001822	kidney development	Lhx1	IMP	MGI:MGI:2385716,MGI:MGI:2675121	Mouse	PMID:15930111
Biological Process	GO:0097477	lateral motor column neuron migration	Lhx1	IMP		Mouse	MGI:MGI:4849611|PMID:20711475
Biological Process	GO:0048382	mesendoderm development	Lhx1	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0072177	mesonephric duct development	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0072164	mesonephric tubule development	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0001823	mesonephros development	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0072278	metanephric comma-shaped body morphogenesis	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0072224	metanephric glomerulus development	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0035502	metanephric part of ureteric bud development	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0072283	metanephric renal vesicle morphogenesis	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0072284	metanephric S-shaped body morphogenesis	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0072284	metanephric S-shaped body morphogenesis	Lhx1	IEP		Rat	PMID:9496787|RGD:8553921
Biological Process	GO:0001656	metanephros development	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0008045	motor neuron axon guidance	Lhx1	IMP		Mouse	MGI:MGI:4849611|PMID:20711475
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Biological Process	GO:0035849	nephric duct elongation	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Biological Process	GO:0072178	nephric duct morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Biological Process	GO:0060066	oviduct development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0035846	oviduct epithelium development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0061205	paramesonephric duct development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0007389	pattern specification process	Lhx1	IMP	MGI:MGI:1857848	Mouse	PMID:15930111
Biological Process	GO:0007389	pattern specification process	Lhx1	IGI	MGI:MGI:1347476	Mouse	PMID:10498685
Biological Process	GO:2000744	positive regulation of anterior head development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx1	IMP		Mouse	MGI:MGI:4849611|PMID:20711475
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx1	IGI	UniProtKB:P61375	Mouse	MGI:MGI:3695495|PMID:17166926
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx1	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:0040019	positive regulation of embryonic development	Lhx1	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:2000543	positive regulation of gastrulation	Lhx1	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation	Lhx1	IMP		Mouse	MGI:MGI:3613206|PMID:16216236
Biological Process	GO:0009791	post-embryonic development	Lhx1	IMP	MGI:MGI:3719681	Mouse	PMID:17664423
Biological Process	GO:0090009	primitive streak formation	Lhx1	IMP	MGI:MGI:1857848	Mouse	PMID:11291865
Biological Process	GO:0090009	primitive streak formation	Lhx1	IMP	MGI:MGI:1857502	Mouse	PMID:11291865
Biological Process	GO:0048793	pronephros development	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0010468	regulation of gene expression	Lhx1	IMP		Mouse	PMID:10328927
Biological Process	GO:0072077	renal vesicle morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Biological Process	GO:0060041	retina development in camera-type eye	Lhx1	IEP		Mouse	MGI:MGI:1353814|PMID:10741426
Biological Process	GO:0010842	retina layer formation	Lhx1	IMP		Mouse	MGI:MGI:3772525|PMID:18094249
Biological Process	GO:0010842	retina layer formation	Lhx1	IEP		Mouse	MGI:MGI:1353814|PMID:10741426
Biological Process	GO:0072050	S-shaped body morphogenesis	Lhx1	IMP		Mouse	MGI:MGI:5009392|PMID:17610272
Biological Process	GO:0032525	somite rostral/caudal axis specification	Lhx1	IMP	MGI:MGI:1857848	Mouse	PMID:11291865
Biological Process	GO:0032525	somite rostral/caudal axis specification	Lhx1	IMP	MGI:MGI:1857502	Mouse	PMID:11291865
Biological Process	GO:0021527	spinal cord association neuron differentiation	Lhx1	IGI	UniProtKB:P61375	Mouse	MGI:MGI:3695495|PMID:17166926
Biological Process	GO:0021510	spinal cord development	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0021537	telencephalon development	Lhx1	IEP		Mouse	MGI:MGI:5050079|PMID:7909549
Biological Process	GO:0006366	transcription by RNA polymerase II	Lhx1	IDA		Mouse	MGI:MGI:3578570|PMID:15857913
Biological Process	GO:0072197	ureter morphogenesis	Lhx1	IGI	MGI:MGI:95663	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Lhx1	IGI	MGI:MGI:95388	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Lhx1	IGI	MGI:MGI:95457	Mouse	PMID:21731775
Biological Process	GO:0072197	ureter morphogenesis	Lhx1	IGI	MGI:MGI:97486	Mouse	PMID:21731775
Biological Process	GO:0001657	ureteric bud development	Lhx1	IMP	MGI:MGI:2385716,MGI:MGI:2675121	Mouse	PMID:15930111
Biological Process	GO:0001655	urogenital system development	Lhx1	IMP	MGI:MGI:2385716,MGI:MGI:2675121	Mouse	PMID:15930111
Biological Process	GO:0035847	uterine epithelium development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0060065	uterus development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0060068	vagina development	Lhx1	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0021517	ventral spinal cord development	Lhx1	IEP		Mouse	MGI:MGI:4849611|PMID:20711475

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern