Lhx1
Gene Detail

Symbol Name ID

Lhx1 LIM homeobox protein 1 MGI:99783

Synonyms

Lim1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

51.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:84517977-84526015 bp, - strand From VEGA annotation of GRCm38   8039 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein lim-1
Gene Tree: Lhx1

Human homologs

Human Homolog		LHX1, LIM homeobox 1
NCBI Gene ID		3975
neXtProt AC		NX_P48742
Human Synonyms		LIM1, LIM-1
Human Chr (Location)		17q12; chr17:35294772-35301915 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for targeted null mutations are small, fail to develop head structures anterior to rhombomere 3 in the hindbrain, lack kidneys and gonads, and show aberrant trajectories of limb motor axons. Most mutants die around embryonic day 10.

 

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, ...
Component	intracellular, nucleus, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (335 records)
Data Summary: Results (982)    Tissues (440)    Images (204)
Theiler Stages: 2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	854
In situ reporter (knock in)	16
Northern blot	19
RT-PCR	60
RNase protection	9

cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(3) cDNA(35) Primer pair(7) Other(7)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000972 (Evidence)
Ensembl Gene Model	ENSMUSG00000018698 (Evidence)
Entrez Gene	16869 (Evidence)
UniGene	4965
DFCI	TC1585486, TC1596981, TC1598921
DoTS	DT.101363239, DT.40165560
NIA Mouse Gene Index	U033206
Consensus CDS Project	CCDS25187.1
International Mouse Knockout Project Status	Lhx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000972	VEGA Gene Model | MGI Sequence Detail	8039	C57BL/6J
transcript	OTTMUST00000001910	VEGA | MGI Sequence Detail	4633	Not Applicable
polypeptide	OTTMUSP00000000925	VEGA | MGI Sequence Detail	406	Not Applicable

All sequences(41) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(3) : SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009791	LIM/homeobox protein Lhx1

References

(Earliest) J:32662 Blatt C, et al., DNA rearrangement of a homeobox gene in myeloid leukaemic cells [published erratum appears in EMBO J 1989 Apr;8(4):1288]. EMBO J. 1988 Dec 20;7(13):4283-90
(Latest) J:194050 Massa F, et al., Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
All references(382)

Other accession IDs

MGD-MRK-16569