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Lhx1 Gene Detail
Summary
  • Symbol
    Lhx1
  • Name
    LIM homeobox protein 1
  • Synonyms
    Lim1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99783
    NCBI Gene: 16869
  • Gene Overview
    MyGene.info: LHX1
Location & Maps
more
  • Sequence Map
    Chr11:84518284-84525535 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7252 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.31 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LHX1, LIM homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LHX1, LIM homeobox 1
    Orthology source: HomoloGene
  • Synonyms
    LIM1, LIM-1
  • Links
    NCBI Gene ID: 3975
    neXtProt AC: NX_P48742

  • Chr Location
    17q12; chr17:36937475-36944615 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 8 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    2 involving Lhx1
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations are small, fail to develop head structures anterior to rhombomere 3 in the hindbrain, lack kidneys and gonads, and show aberrant trajectories of limb motor axons. Most mutants die around embryonic day 10.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000972 VEGA Gene Model | MGI Sequence Detail 7252 C57BL/6J ±  kb
transcript OTTMUST00000001910 VEGA | MGI Sequence Detail 3846 Not Applicable  
polypeptide OTTMUSP00000000925 VEGA | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 3
    cDNA 40
    Primer pair 8
    Other 11

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16569
References
more
  • Summaries
    All 452
    Developmental Gene Expression 407
    Gene Ontology 23
    Phenotypes 51
  • Earliest
    J:32662 Blatt C, et al., DNA rearrangement of a homeobox gene in myeloid leukaemic cells [published erratum appears in EMBO J 1989 Apr;8(4):1288]. EMBO J. 1988 Dec 20;7(13):4283-90
  • Latest
    J:231591 Iskusnykh IY, et al., Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory