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Lhx1
Gene Detail
Symbol

Name
ID
Lhx1
LIM homeobox protein 1
MGI:99783
Synonyms
Lim1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:84518284-84525535 bp, - strand
From VEGA annotation of GRCm38

  7252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein lim-1
Gene Tree: Lhx1

Human
homologs
Human Homolog LHX1, LIM homeobox 1
NCBI Gene ID 3975
neXtProt AC  NX_P48742
Human Synonyms  LIM1, LIM-1
Human Chr (Location)  17q12; chr17:36937475-36944615 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations are small, fail to develop head structures anterior to rhombomere 3 in the hindbrain, lack kidneys and gonads, and show aberrant trajectories of limb motor axons. Most mutants die around embryonic day 10.
 
Interactions
Lhx1 interacts with 342 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, ...
Component intracellular, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (369 records)
Data Summary: Results (1412)    Tissues (559)    Images (297)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 1018
In situ reporter (knock in) 92
Northern blot 19
RT-PCR 225
RNase protection 9
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(3) cDNA(39) Primer pair(8) Other(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000972 (Evidence)
Ensembl Gene ModelENSMUSG00000018698 (Evidence)
Entrez Gene16869 (Evidence)
UniGene4965
DFCITC1585486, TC1596981, TC1598921
DoTSDT.101363239, DT.40165560
NIA Mouse Gene IndexU033206
Consensus CDS ProjectCCDS25187.1
International Mouse Knockout Project StatusLhx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000972 VEGA Gene Model | MGI Sequence Detail 7252 C57BL/6J ±  kb
transcript OTTMUST00000001910 VEGA | MGI Sequence Detail 3846 Not Applicable 
polypeptide OTTMUSP00000000925 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(10)
Polymorphisms
RFLP(3) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009791 LIM/homeobox protein Lhx1
References
(Earliest) J:32662 Blatt C, et al., DNA rearrangement of a homeobox gene in myeloid leukaemic cells [published erratum appears in EMBO J 1989 Apr;8(4):1288]. EMBO J. 1988 Dec 20;7(13):4283-90
(Latest) J:211807 Bedont JL, et al., Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Rep. 2014 May 8;7(3):609-22
All references(419)
Other
accession IDs
MGD-MRK-16569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory