Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LAMP2
  • Mouse genes Lamp2
  • Rat genes Lamp2
  • Zfish genes lamp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lamp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	LAMP2	IPI	UniProtKB:Q9NP78	Human	PMID:22641697
Molecular Function	GO:0005515	protein binding	LAMP2	IPI	UniProtKB:Q9NP78	Human	PMID:21194361
Molecular Function	GO:0005515	protein binding	LAMP2	IPI	UniProtKB:Q96PG8	Human	PMID:26212789
Molecular Function	GO:0005515	protein binding	Lamp2	IPI	UniProtKB:Q8CIF6	Mouse	MGI:MGI:5908512|PMID:27046251
Molecular Function	GO:0005515	protein binding	Lamp2	IPI	UniProtKB:Q9NP78	Mouse	MGI:MGI:6695860|PMID:21194361
Molecular Function	GO:0005515	protein binding	Lamp2	IPI	UniProtKB:Q6AYS3	Rat	PMID:12505983|RGD:10412300
Molecular Function	GO:0005515	protein binding	Lamp2	IPI	UniProtKB:P34058	Rat	PMID:18644871|RGD:10412301
Molecular Function	GO:0005515	protein binding	Lamp2	IPI	UniProtKB:P82995	Rat	PMID:18644871|RGD:10412301
Molecular Function	GO:0019904	protein domain specific binding	Lamp2	IPI	UniProtKB:Q9NP78	Mouse	MGI:MGI:5499709|PMID:22641697
Cellular Component	GO:0044754	autolysosome	LAMP2	IDA		Human	PMID:25327288
Cellular Component	GO:0000421	autophagosome membrane	Lamp2	IDA		Mouse	MGI:MGI:3038873|PMID:12221139
Cellular Component	GO:0005768	endosome	Lamp2	IDA		Rat	PMID:16085051|RGD:1581606
Cellular Component	GO:0070062	extracellular exosome	LAMP2	IDA		Human	PMID:15908444
Cellular Component	GO:0070062	extracellular exosome	LAMP2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LAMP2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	LAMP2	IDA		Human	PMID:25645918
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	LAMP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	LAMP2	IDA		Human	PMID:15229288
Cellular Component	GO:0005770	late endosome	Lamp2	IDA		Mouse	PMID:14668490
Cellular Component	GO:0031902	late endosome membrane	LAMP2	IDA		Human	PMID:21896273
Cellular Component	GO:0031902	late endosome membrane	Lamp2	IDA		Mouse	PMID:21896273
Cellular Component	GO:1990836	lysosomal matrix	Lamp2	IDA		Rat	PMID:18644871|RGD:10412301
Cellular Component	GO:0005765	lysosomal membrane	LAMP2	IDA		Human	PMID:15297306
Cellular Component	GO:0005765	lysosomal membrane	LAMP2	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	LAMP2	IDA		Human	PMID:21896273
Cellular Component	GO:0005765	lysosomal membrane	Lamp2	IDA		Mouse	MGI:MGI:3773765|PMID:18022370
Cellular Component	GO:0005765	lysosomal membrane	Lamp2	IDA		Mouse	PMID:21896273
Cellular Component	GO:0005765	lysosomal membrane	Lamp2	IDA		Rat	PMID:11082038|RGD:1581607
Cellular Component	GO:0005765	lysosomal membrane	Lamp2	IDA		Rat	PMID:18644871|RGD:10412301
Cellular Component	GO:0005765	lysosomal membrane	Lamp2	IDA		Rat	PMID:8662539|RGD:10412302
Cellular Component	GO:0005764	lysosome	LAMP2	IDA		Human	PMID:12536145
Cellular Component	GO:0005764	lysosome	LAMP2	IDA		Human	PMID:15229288
Cellular Component	GO:0005764	lysosome	LAMP2	IDA		Human	PMID:19535332
Cellular Component	GO:0005764	lysosome	LAMP2	IDA		Human	PMID:28743268
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:17185018
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:24334765
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:19549681
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:16093322
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:14557411
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:12775715
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:28504966
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Mouse	PMID:16399794
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Rat	PMID:11082038|RGD:1581607
Cellular Component	GO:0005764	lysosome	Lamp2	IDA		Rat	PMID:19337031|RGD:4892338
Cellular Component	GO:0016020	membrane	LAMP2	IDA		Human	PMID:15297306
Cellular Component	GO:0016020	membrane	LAMP2	IDA		Human	PMID:23093945
Cellular Component	GO:0045121	membrane raft	Lamp2	IMP		Rat	PMID:20797626|RGD:10412296
Cellular Component	GO:0030670	phagocytic vesicle membrane	Lamp2	IMP	MGI:MGI:2446573	Mouse	PMID:9670047
Cellular Component	GO:0031088	platelet dense granule membrane	LAMP2	IDA		Human	PMID:15297306
Biological Process	GO:0097352	autophagosome maturation	Lamp2	IMP		Mouse	MGI:MGI:5805578|PMID:27628032
Biological Process	GO:0006914	autophagy	Lamp2	IMP		Mouse	MGI:MGI:3038873|PMID:12221139
Biological Process	GO:0009267	cellular response to starvation	Lamp2	IMP		Mouse	MGI:MGI:5805578|PMID:27628032
Biological Process	GO:0061684	chaperone-mediated autophagy	LAMP2	IMP		Human	PMID:24880125
Biological Process	GO:0061684	chaperone-mediated autophagy	LAMP2	IMP		Human	PMID:27628032
Biological Process	GO:0061684	chaperone-mediated autophagy	LAMP2	IDA		Human	PMID:36586411
Biological Process	GO:0061684	chaperone-mediated autophagy	Lamp2	IGI	UniProtKB:P13473	Mouse	MGI:MGI:3813410|PMID:18644871
Biological Process	GO:0061684	chaperone-mediated autophagy	Lamp2	IMP		Mouse	MGI:MGI:5805578|PMID:27628032
Biological Process	GO:0061684	chaperone-mediated autophagy	Lamp2	IMP		Mouse	PMID:18579532
Biological Process	GO:0061684	chaperone-mediated autophagy	Lamp2	IDA		Rat	PMID:11082038|RGD:1581607
Biological Process	GO:1905146	lysosomal protein catabolic process	LAMP2	IMP		Human	PMID:24880125
Biological Process	GO:0016236	macroautophagy	lamp2	IMP	ZFIN:ZDB-GENO-200505-12	Zfish	PMID:31228518
Biological Process	GO:0046716	muscle cell cellular homeostasis	Lamp2	IMP	MGI:MGI:2385811	Mouse	PMID:20060297
Biological Process	GO:0050821	protein stabilization	Lamp2	IMP		Mouse	MGI:MGI:5499709|PMID:22641697
Biological Process	GO:0006605	protein targeting	Lamp2	IMP		Mouse	MGI:MGI:5805578|PMID:27628032
Biological Process	GO:0006605	protein targeting	Lamp2	IMP		Mouse	MGI:MGI:3038873|PMID:12221139
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	LAMP2	IMP		Human	PMID:27628032
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	Lamp2	IMP		Mouse	MGI:MGI:5805578|PMID:27628032
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	Lamp2	IGI	UniProtKB:P63018	Rat	PMID:18644871|RGD:10412301
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	Lamp2	IMP		Rat	PMID:18644871|RGD:10412301
Biological Process	GO:0031647	regulation of protein stability	LAMP2	IMP		Human	PMID:26212789

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern